Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Inhaled Corticosteroids"”.
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Effectiveness of inhaled corticosteroids in preventing morbidity and mortality in individuals with chronic obstructive pulmonary disease and the impact of coexisting asthma
… burden of illness posed by COPD alone. Inhaled corticosteroids (ICS) are currently recommended for the management of COPD among individuals with frequent exacerbations; however, the ability of inhaled corticosteroids to reduce death and hospitalizations among individuals with COPD is …
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GENETIC ANALYSIS OF THE GLUCOCORTICOID PATHWAY IN THE SEVERE ASTHMA RESEARCH PROGRAM
… due to a poor response to treatment, namely inhaled corticosteroids (ICS). Understanding the molecular determinants that dictate steroid response would be a powerful tool in devising more effective treatment regiments for these individuals.
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Immunopathological and Structural Alterations in Difficult to Control Asthma
… with bronchodilators and low to moderate dose inhaled corticosteroids. However, an estimated 5-10% of the population presents a more troublesome disease, often referred to as severe asthma. The aim of present thesis was to study the relationship between histopathological alterations and …
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Non-invasive method of measuring airway inflammation : exhaled nitric oxide
… bronchodilator therapy only, or on regular inhaled corticosteroids. 6. To compare the levels of NO in a pilot group of asthmatic children before and after commencement of inhaled corticosteroids. Methods A Dasibi Environmental Corporation Model 2107 chemiluminescence analyser was adapted …
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Investigation into the Bronchoprotective and Anti-inflammatory Properties of RGS2
… management of asthma involves treatment with inhaled corticosteroids (ICS) and long-acting β2-adrenoceptor agonists (LABAs). Regulator of G-protein signalling (RGS) 2 inhibits signalling from Gq protein-coupled receptors. In humans, combinations of a glucocorticoid and a LABA synergistically …
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Impact of Cost Sharing Levels on Adherence to Controller Drugs and Consequent Outcomes among Asthma Patients
… significantly negative. The drop in adherence to Inhaled Corticosteroids (ICS) with respect to cost sharing was greater after the patients were stepped to the dual controller therapy. Comparison of subgroups that used ICS+ LABA and ICS + LTRA revealed that the subjects ICS+LTRA subgroup are …
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Determining the Effects and Signaling Properties of β-Blockers in House Dust Mite-Driven Murine Models of Asthma
… gold-standard drugs for asthma therapy include inhaled corticosteroids (ICS) and β2-adrenoceptor (β2AR) agonists. However, chronic monotherapy with β2AR agonists has been associated with worsening of asthma control and an increase in asthma-related mortality. Previous studies in our laboratory …
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MicroRNA Nanocarriers for the Treatment of Chronic Obstructive Pulmonary Disease
… as; bronchodilator medications, antibiotics, inhaled corticosteroids and rehabilitation. However, none of the available pharmacological or non-pharmacological treatments for COPD have been shown to delay or correct long-term defects in lung function. Small nucleic acids such as non-coding RNA …
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The Physical Chemistry of pMDI Formulations Derived from Hydrofluoroalkane Propellants. A Study of the Physical Behaviour of Poorly Soluble Active Pharmaceutical Ingredients; Bespoke Analytical Method Development Leading to Novel Formulation Approaches for Product Development.
… understood and their capacity for solubilising inhaled pharmaceutical products (IPPs) and excipients used historically in CFCs differ significantly. There is therefore a drive to establish methodologies to study these systems in-situ and post actuation to adequately direct formulation strategies …
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New aspects of tissue mast cells in inflammatory airway diseases
… with uncontrolled asthma despite treatment with inhaled corticosteroids, an increase of MCTC was found in the bronchi and alveolar parenchyma. In mild and uncontrolled asthma a significant increase of the expression of FcεRI was found in the alveolar parenchyma In conclusion, the prevailing MCT …
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Effects of IL-33 on the interaction between HMC-1 cells and human airway smooth muscle cells
… asthma. Treatments include β2-agonists and inhaled corticosteroids, although there is no definitive cure for the disease. Asthma results in a plethora of pathological processes, present in many types of asthma. This can make differential diagnosis difficult, although several processes are …
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Do Statins Improve Outcomes in Patients With Asthma on Inhaled Corticosteroid Therapy? A Retrospective Analysis of the Mississippi Medicaid Database 2002-2004.
… days prior to which the subject had at least 1 inhaled corticosteroid (ICS) prescription and at least an 80% adherence rate to statins. Medicaid beneficiaries identified as asthmatics and on ICS therapy, but not on statins were selected as the unexposed population. Each subject in the exposed …
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Characterising epithelial to mesenchymal transition and pro-fibrotic processes in chronic obstructive pulmonary disease
… are limited including bronchodilators and inhaled corticosteroids that are poorly effective. Linked with a significant history of cigarette smoking, pathology is characterised by recruitment of inflammatory cells to the lung (alveolar macrophages, neutrophils and lymphocytes: TH1 and CD8); …
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The management of children's asthma in primary care : Are there ethnic differences in care?
… in completion rates. The overall use of inhaled corticosteroid medications had increased since previous New Zealand research was published. Multivariable modelling that adjusted for potential confounders did not identify ethnic differences in the use of inhaled corticosteroids or oral …