Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Ingenuity pathway analysis"”.
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Functional genomics in the stroke-prone spontaneously hypertensive rat: genome wide and candidate gene analysis
… glutathione s-transferse mu type 1 (Gstm1). Ingenuity pathway analysis of renal microarrays in 5 and 16-week SHRSP, normotensive Wistar Kyoto (WKY) and chromosome 2 congenic rats identified differential expression of several glutathione cycling genes. The Gstm1 promoter was investigated by …
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Potential Rest Targets In Neural Stem Cells and Glioblastoma-Derived Stem Cells
… experiments and genome-wide mRNA expression analysis in GSCs, and we were able to identify REST-regulated genes in GSCs. This was accomplished, after screening concordantly regulated genes in NSCs and GSCs, utilizing two RE1 databases, and setting two-fold expression as filters on the …
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Characterization of The Role(S) of Env Protein of Human Endogenous Retrovirus-K In Multiple Human Cancers
… (NSG) mice. Moreover, results from RNA Seq and Ingenuity Pathway Analysis (IPA) suggested the involvement of Kenv in the mevalonate pathway. In addition, introduction of Kenv into the premalignant human breast cell line MCF-10AT led to increased cell proliferation and colony formation. These …
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Developing brain and systemic inflammation: a "Toll-like" link with consequences
… choroid plexus followed by transcriptome cluster analysis and Ingenuity Pathway Analysis revealed potential mechanisms of leukocyte infiltration, including a specific chemotaxis signature and cytoskeleton-related pathways. Finally, we show that N-acetylcysteine treatment inhibits TLR2-mediated …
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Biochemical changes in animal models of fetal alcohol spectrum disorder
… a comprehensive understanding of the biochemical pathways modified in prenatal ethanol exposure. Biomarkers are also lacking. Our results demonstrate the vast array of biochemical pathways modified in the chronic ethanol exposure zebrafish model of FASD. Many of these pathways agree with existing …
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Epigenetic Modulation of Synaptic Resilience in Alzheimer’s Disease
… from control subjects and AD patients. Using Ingenuity Pathway Analysis several microRNAs were identified as potential upstream regulators of the observed changes in the postsynaptic proteome of NDAN. MicroRNA-149, -4723 and -485 were confirmed to have differential expression in AD and NDAN …
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An Integrated Omics Approach to Define the Molecular Mechanisms of Low Dose, High Charge, High Energy Irradiation (HZE) in Liver
… from transcriptomics and proteomics utilizing ingenuity pathway analysis (IPA), several pathways involved in mitochondrial function were altered after HZE irradiation. Lipids and metabolites also exhibited changes that are connected to mitochondrial function. Molecular assays for determining …
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Proteomic identification of putative biomarkers of neo-adjuvant chemotherapy resistance in luminal (ER+) breast cancer
… 3 2D-PAGE/MS experiments was then analysed using Ingenuity Pathway Analysis (IPA; Ingenuity Systems). A pilot series of archival samples was used for clinical validation of putative predictive biomarkers.Results:89 differentially expressed proteins (DEPs) were seen in the 4 further AbMA …
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The identification of biomarkers of chemotherapy resistance in breast cancer using comparative proteomics
… with chemotherapy resistance, using proteomic analysis of fresh breast cancer tissue samples.Materials and Methods:Chemotherapy-sensitive (CS) and chemotherapy-resistant (CR) tumour samples were collected from breast cancer patients who received neoadjuvant therapy consisting of epirubicin with …
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Stemness status in differentiated and undifferentiated glioma cells
… measurements of chemosensitivity and cell cycle analysis under undifferentiation conditions added to the cytotoxic potential of Taxol and showed an enhanced sensitivity of serum-deprived cells towards chemotherapeutic drugs. Moreover, proteomic analysis produced a wide dataset, depicting the …
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Aberrant expression of miR-133a in endothelial cells inhibits angiogenesis by altering the expression of key angiogenic genes
… genes involved in the regulation of signalling pathways, which play a key role in angiogenesis. The results have been further validated by qPCR, which revealed that aberrant expression of miR-133a-3p led to a decrease in the expression of genes encoding pro-angiogenic molecules, whilst …
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Next Generation Sequencing Reveals Gene Expression Patterns in the Zebrafish Inner Ear Following Growth Hormone Injection
… Sequencing (NGS) to examine the genes and pathways that are significantly regulated in the zebrafish inner ear following sound exposure and GH injection. Four groups of 20 zebrafish each were exposed to a 150 Hz tone at 179 dB re 1μPa RMS for 40 h. Zebrafish were injected with either salmon …
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Translational Studies of Acute and Chronic Traumatic Brain Injury: Molecular Profiling of Tissue and Biofluids
… n= 56). Using a bioinformatic platform (Ingenuity Pathway Analysis), these studies identified genes and prominent cell signaling pathways that are dysregulated weeks to months after TBI. Genes and pathways were predominately associated with immune and regenerative signaling. Later, …
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Plasma membrane calcium ATPase 4 (PMCA4) and inflammation of the aortic endothelium
… of the metalloproteinases ADAMTS1 and -4. Ingenuity pathway analysis (IPA) revealed a role in immune cell trafficking with a propensity to develop aneurysms (activation z-score,-1.177). Similarly, silencing PMCA4 enhanced the VEGF-induced expression of ADAMTS1, VCAM-1 and SELE. Cyclosporin …
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Proteomic identification of putative biomarkers of radiotherapy resistance
… rectal cancer cell line models and the proteomic analysis of 2 RR oral cancer cell lines and 2 RR rectal cancer cell lines. Proteomic analysis included 3 different platforms, namely antibody microarray, 2D MS and iTRAQ. Data mining of all biomarker discovery data, from all 7 novel RR cell lines …
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Tumor-Cell Derived Inhibin, Beta A Is Essential For Adrenergic Effects On Fibroblast Activation
… and metastasis.</p> <p><strong>Methods:</strong> Ingenuity Pathway Analysis and NetWalker were used to assess gene expression data from patients with known CESD (Center for Epidemiological Studies-Depression)-score alongside microdissected CAFs from primary ovarian cancer. Tumor samples from mice …
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Mechanisms and Targeting of Neurodevelopmental Regulator Rest In Medulloblastoma Dissemination
… and dramatically reduced survival of mice. Analysis of patient samples revealed that REST and CXCR4 levels were concurrently high in patients with metastasis in a subset of SHH (SHH-beta) patients. Examination of human MB cell lines strengthened the observation that REST elevation increased …
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TREM1-Mediated Neuroinflammation is Critical to Global Ischemia-Induced Neurodegeneration and Cognitive Deficits.
… ischemia via 4-vessel occlusion. RNA-seq and Ingenuity Pathway analysis determined that, following global ischemia, genes related to neuroinflammation, and the triggering receptor expressed on myeloid cells-1 (TREM1) signaling are significantly upregulated in the hippocampal CA1. TREM1 is a …
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Transcriptional variation in muscle from cattle with alternative NCAPG/LCORL QTL genotypes
… using weighted gene co-expression network analysis (WGCNA) revealed eleven co-expression gene network modules significantly correlated with genotype. Of these, the LCORL containing module (Blue) showed the highest positive correlation. Gene Ontology enrichment analysis and Ingenuity Pathway …
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Multi-omics Data Integration for Identifying Disease Specific Biological Pathways
Pathway analysis is an important task for gaining novel insights into the molecular architecture of many complex diseases. With the advancement of new sequencing technologies, a large amount of quantitative gene expression data have been continuously acquired. The springing up omics data sets such …
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