Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Infrared Spectroscopic Imaging"”.
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Mid infrared spectroscopic imaging and tomography
Fourier Transform Infrared (FT-IR) Spectroscopic Imaging is an optical technique that simultaneously provides morphological (two dimensional) and mid-infrared spectral (one dimensional) information for a specimen under observation. In this dissertation, we develop a new instrument that extends the …
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Characterizing intercellular heterogeneity in tumor microenvironments via infrared spectroscopic imaging
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-12-01
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Discrete frequency mid-infrared spectroscopic imaging using quantum cascade lasers
Infrared (IR) spectroscopic imaging is an analytical technique that directly images the spatial distribution of chemical components within a sample in the absence of external contrast agents. This is especially advantageous with biological samples where the mid to far-infrared wavelength range …
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Translation of infrared spectroscopic imaging for digital histopathology of clinical specimens
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01
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Quantum cascade laser-based mid-infrared spectroscopic imaging systems with polarization capabilities
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01
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Characterization of molecular dynamic changes in tissue model systems using Fourier transform infrared spectroscopic imaging
… animal tissue models using the emerging FT-IR imaging technology combined with conventional biological and histological tools. These models are then examined for their chemical and biochemical stability, and used to monitor tumor-associated changes in stroma and cellular responses and …
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Use of fourier transform- infrared spectroscopic imaging as a tool for understanding early molecular events driving breast cancer progression
… spectra obtained through Fourier Transform infrared (FT-IR) spectroscopic imaging. Fibroblasts were stimulated using the growth factor TGFβ1, co-culture with MCF-7 tumorigenic breast epithelial cells, and co-culture with MCF10A normal breast epithelial cells in trans-well co-culture and also …
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Quantitative chemical imaging: A top-down systems pathology approach to predict colon cancer patient survival
… this by analyzing tissue microarrays using infrared spectroscopic imaging. We developed supervised classification algorithms that were used to reliably segment colon tissue into histological components, including differentiation of normal and desmoplastic stroma. Thus, infrared spectroscopic …
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Leveraging Spectra to Improve the Resolution and Usability of Mid-Infrared Biomedical Microscopy: A Case Study in Bone Marrow Grading
Histological imaging is the current gold standard for disease diagnosis and prognosis. The current histological methods rely on techniques, such as chemical staining and pathological analysis, that are non-quantitative, subjective, and limited to specific biomarkers. Over the past decade, research …
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Breast cancer diagnosis using Fourier transform infrared imaging and statistical learning
… building combinatorial approaches using chemical imaging, histopathology images, machine learning and deep learning. An emerging area of investigation is using spectrometry to perform tissue analysis that utilizes chemical imaging coupled to machine learning to identify spectral signatures …
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Development of Multi-modal Optical Coherence Tomography Imaging Systems and Probes
Optical Coherence Tomography (OCT) is a powerful imaging modality widely used in medical diagnostics and biological research for its non-invasive, high-resolution, and depth-resolved properties. Additionally, OCT has demonstrated remarkable versatility in various applications. In this thesis, we …
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Nanoparticle probes based on metal carbonyl chemical species for biological sensing with infrared spectroscopy
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-03-01 without embargo terms
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Systems pathology: a bottom-up approach for understanding fibroblast-epithelial interactions in breast cancer
… in tumor biopsies using an emerging chemical imaging technology. It has been described extensively that the tumor microenvironment, or stroma, can promote or suppress cancer phenotypes in many tissues. We hypothesized that interaction with fibroblasts, the predominant cell type found in the …