Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Infralimbic Cortex"”.
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FEAR EXTINCTION AND INFRALIMBIC CORTEX IMPAIRMENT AFTER MILD TRAUMATIC BRAIN INJURY
… to altered neurocircuitry, particularly in the infralimbic cortex (IL), a key region in fear extinction. Despite extensive evidence of impaired fear extinction in mild TBI patients and animal models, the specific mechanisms underlying this deficit remain poorly understood. This study aimed to …
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Investigating the role of extrasynaptic GABAA receptors located in the infralimbic cortex in the binge-like alcohol intake of male C57BL/6J mice
… of extrasynaptic GABAA receptors located in the infralimbic cortex (ILC) in the binge-like alcohol intake of male C57BL/6J (B6) mice. The ILC is of interest due to its demonstrated involvement in stress reactivity and alcohol exposure has been shown to interfere with extinction learning; …
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Brain substrates of behavioural endophenotypes predictive of compulsive drug-seeking
… shown to predict lower grey matter volume in the infralimbic cortex and ventral striatum. Functionally, compulsivity and stickiness were predicted by decreased connectivity between the prelimbic cortex and the anterior cingulate cortex with the posterior dorsomedial striatum. In summary, this …
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The Effect of Typical and Atypical Antipsychotics on the MK-801 Induced Deficit in Behavioural Inhibition
… immunohistochemical labeling of pERK1/2 in the infralimbic cortex (IL) was examined after extinction lever pressing to determine the importance of the IL in mediating these behavioral changes. A dose-response curve revealed an extinction deficit following administration of 0.1 mg/kg of MK-801. …
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Neurochemical and Neuroanatomical Basis Of Reversal Learning In The Rat
… focusing on the lateral and medial orbitofrontal cortex, as well as regions of the medial prefrontal cortex. Local temporary inactivation of these structures via infusion of a muscimol/baclofen mixture produced dissociable effects. Inactivation of the infralimbic cortex led to a significant …
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Adenosine monophosphate-activated protein kinase regulates reward regions of the brain during cocaine sensitization
… dorsal striatum and increased in the prefrontal cortex, though only broad brain regions were investigated. Subregions of the prefrontal cortex, the prelimbic and infralimbic cortices, differentially regulate reward signaling. For example, the prelimbic cortex is known to be necessary for …
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The Role of the Infralimbic-Basal Forebrain Pathway in Fear Extinction
<p>The medial prefrontal cortex (mPFC) is a key region for emotion regulation, and its failure to regulate extinction of aversive memories is associated with Post Traumatic Stress Disorder. Study of how the Infralimbic cortex (IL), a subregion of the mPFC, directly communicates with the Basolateral …
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Neural Plasticity in the Amygdala Across the Development of an Incentive Cocaine Seeking Habit
… changes in activity in areas of the prefrontal cortex (PFC) from which it receives inputs, namely the orbitofrontal cortex, the prelimbic cortex, and the infralimbic cortex. Using the immediate early gene cFos as a marker of cellular activity, I performed RNAscope on brain sections encompassing …
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Investigating reinforcement learning processes in depression and substance use disorder: translational, computational and neuroimaging approaches.
… from the amygdala to the anterior cingulate cortex, infralimbic cortex and insular cortex compared to males. The subsequent chapter uses a computational approach to investigate latent vulnerability variables in cocaine addiction. A longitudinal dataset acquired in rats was analysed, which …