Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Influenza hemagglutinin"”.
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Influenza hemagglutinin expression in Nicotiana tabacum and Nicotiana benthamiana.
Influenza infects millions of people each year. Hemagglutinin (HA) is the major surface protein of the influenza virus and the best target as a vaccine candidate. Transgenic plants have significant potential for proper expression of HA to serve as an influenza vaccine. An HA3 DNA construct for …
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Intracellular Trafficking of Influenza Hemagglutinin and Members of the Low Density Lipoprotein Receptor Family
… in the biosynthetic and endocytic pathways. Influenza hemagglutinin is sorted to the apical membrane in polarized epithelial cells by a mechanism mediated by an association with lipid microdomains known as lipid rafts. Lipid rafts and their associated proteins are operationally defined by …
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Anatomy of the coiled coil and its role in the conformational change of influenza hemagglutinin
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1995.
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The Effect Of Maternal Antibodies On Anti-Viral Immunity In Infant Mice
… infants. Here, we establish mouse models of influenza virus- and flavivirus-specific maternal antibody transfer. We show that influenza virus-specific maternal antibodies protect infant mice from influenza disease and that Zika virus-specific maternal antibodies protect infants from Zika …
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Development and application of tools for glycan characterization
… the significance of goblet cells and mucins in influenza infection. This project explored the potential benefits of a glycoprotein direct binding assay as a way to obtain quantitative information about lectin and influenza hemagglutinin specificities. Using mucins adsorbed to a polystyrene …
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FMF assay for assessing vaccine generated antibodies in a biomimetic manner
… used for assessing the vaccine response, since influenza vaccine has been administered in people (1940). Such assays are not always predictive regarding the protection conferred by the influenza vaccine and are not able to monitor neutralization related to stem region of influenza hemagglutinin …
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Down-Regulation of Natural Killer Cell Activation in Response to Influenza Virus in Older Adults
<p>Immune senescence contributes to influenza-associated high mortality and morbidity and reduced vaccine efficacy in elderly people. Type I T cell (Thl)-mediated immunity plays a significant role in Immune responses to influenza infection and vaccination. Natural killer (NK) cells secrete …
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Creating a Marked Mycobacterium avium subsp. paratuberculosis Vaccine Strain and Detecting Marker-Specific Immune Responses in Calves
… (MAP1693c) in the MAP genome with an HA (human influenza hemagglutinin) epitope-tagged immunogenic gene (PepA) via allelic exchange. Once gene replacement was confirmed, these markers were evaluated in a calf infection trial, where 17 Holstein-Friesian dairy calves were inoculated with either …
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Decoding structure-function relationships of glycans
… glycans and GBPs in two areas: i) the role of hemagglutinin-glycan receptor specificity in human adaptation and pathogenesis of influenza and ii) the function of glycan regulation of cell-microenvironment interaction in cancer progression. Section 1: Influenza poses a significant public health …
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Analysis of cyclin dependent kinases in Leishmania
… acid sequence YPYDVPDYA, derived from the human influenza hemagglutinin (HA) protein. Plasmids that contained C and N-terminal HA tagged L. major CYCA were used to transfect WT cells and cells extracts of resistant cell lines analysed by western blot. Both C and N-terminal HA tagged CYCA were …
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High-throughput profiling of viral class I fusion proteins via mammalian antigen display
Viral infections, particularly epidemics and pandemics, pose a significant threat to global health, causing substantial morbidity, mortality, and socioeconomic disruption. Moreover, viruses can cause chronic disease long after initial infection. While modern technologies enable early outbreak …
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High-throughput profiling of viral class I fusion proteins via mammalian antigen display
Viral infections, particularly epidemics and pandemics, pose a significant threat to global health, causing substantial morbidity, mortality, and socioeconomic disruption. Moreover, viruses can cause chronic disease long after initial infection. While modern technologies enable early outbreak …