Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 147 for “"Influenza Virus"”.
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H5N1 Influenza Virus Induces a Parkinsonian Pathology
<p> The greatest threat for an influenza pandemic at this time is posed by the highly pathogenic H5N1 avian influenza virus. To date, 63% of the 436 known human cases of H5N1 infection have proven fatal. Animals infected by H5N1 viruses have demonstrated acute neurological signs ranging from mild …
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CD8⁺ T Cell Response to Influenza Virus
… and to people with compromised immune systems. Influenza has a characteristic course of infection, and is often effectively dispatched by the immune system. The cell-mediated lysis of infected cells is a particularly important step in clearing the infection. Antigen specific CD8+ T lymphocytes …
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Epidemiology and risk factor analysis of avian influenza virus
Background: The avian influenza virus may cause severe outbreaks in the poultry population and may occasionally infect humans exposed to infected poultry. The relative occurrence of the disease varies upon the infectious agent and the subtype, the composition of the population exposed and prior …
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The Role of NS1-BP in Influenza Virus Replication
Influenza A viruses are negative-sense, segmented RNA viruses which cause about 500,000 deaths worldwide per year. Genomic studies have shown that the non-structural protein (NS1) of influenza A virus is a major virulence factor that is essential for pathogenesis. NS1 is a multifunctional protein …
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Intrinsic genetic resistance of lymphocytes to influenza virus infection
… protection of lymphocytes against infection by influenza virus. There was absence of viral transcription in the lymphocytes of HLA-A homozygous subjects, although all monocytes were infected.\r\nMy specific aim was to determine if such resistance was evident in HLA-B homozygous subjects as well …
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Influenza Virus Detection and Surface Decontamination using Ozone Gas
Influenza is a commonly circulating virus that can cause between 9 and 41 million flu cases per year (Centre for Disease Control, 2022). These infections can be the precursor to secondary infections such as pneumonia, thus posing a risk to the population. This could be mitigated by implementing a …
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Investigation of Swine Influenza Virus Genetic Diversity and Evolution
<p>Influenza A exists primarily in a waterfowl reservoir and readily infects numerous avian and mammalian species. In swine, numerous subtypes and antigenic lineages of swine influenza virus (SIV) co-circulate. The reassortment of viral RNA segments in cells infected by multiple viruses can lead to …
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Epidemiology of Swine Influenza Virus in Cattle (Respiratory Diseases)
Various strains of influenza viruses have been isolated from ruminants and antibody responses detected by serological tests. The widespread occurrence of swine influenza virus (SIV) justifies studies to assess the importance of other animals that cohabitate with swine as potential reservoirs.
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USING SINGLE VIRION FUSION ASSAY TO STUDY INFLUENZA VIRUS ENTRY
Understanding the mechanism of influenza virus entry is critical for effectively developing anti-viral drugs and vaccines. The entry of influenza virus is mediated by two proteins: hemagglutinin (HA) and neuraminidase (NA). During virus infection, HA first binds to sialic acid moieties on …
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Examining the effects of environmental compounds on influenza virus ecology
Influenza A virus (IAV) is a global threat. Infections in humans and highly-pathogenic IAV outbreaks in livestock substantially burden the economy. All past pandemics of IAV in humans and outbreaks in livestock have origins in viruses that previously circulated among wild aquatic birds, which are …
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Assessment of the Zoonotic Potential of a Novel Bovine Influenza Virus
<p>A novel orthomyxovirus was recently identified from pigs, with subsequent work suggesting the natural reservoir being bovine populations. The virus had genome characteristics most similar to influenza C viruses (ICV) but, due to the extent of sequence divergence, was proposed as a new genus, …
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Humanized mice to test vaccination against influenza virus via dendritic cells.
… To test DC biologyin vivo, we first used live influenza A/PR8/34 (H1N1) virus. Upon intranasal inoculation, all subsets of human antigen presenting cells were activated. Matured DCs were found accumulated in mediastinal lymph nodes. To evaluate the value of these mice for testing human …
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QCM Aptasensor for Rapid and Specific Detection of Avian Influenza Virus
… has been a need for rapid detection of avian influenza virus (AIV) H5N1 due to it being a potential pandemic threat. Most of the current methods, including culture isolation and PCR, are very sensitive and specific but require specialized laboratories and trained personnel in order to complete …
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Exploring the roles of key lipids in the influenza virus lifecycle
The influenza virus is a common respiratory pathogen with the capacity to cause global pandemics affecting millions of people, contributing substantially to overall mortality and morbidity. Thus, considerable research focuses on the prevention and treatment of influenza virus infection. Despite the …
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A tool of "barcoded viruses" to study influenza virus transmission dynamics
… establish a novel version of powerful “barcode viruses” as a tool for studying the replication and transmission dynamics of influenza virus in vitro and in vivo. Five barcoded APR8 viruses were firstly used to investigate infection kinetics (e.g. single- and multi-hit events, particle clumping …
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Untersuchung Influenza Virus-induzierter Signalprozesse und deren Bedeutung in der Wirtszell-Abwehr
Eine Influenza A Virus Infektion induziert die Expression zahlreicher Gene, einschließlich der TypI Interferone, die eine erste Abwehrlinie gegen virale Infektionen bilden. Hierbei ist IFNb das wichtigste Zytokin. IFNb wird durch einen multimeren Komplex, das Enhanceosom kontrolliert, das …
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