Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"Influenza Vaccine"”.
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Optimization of influenza vaccine strain selection
… (WHO) is responsible for making annual vaccine strains recommendation to countries around the globe. However, various studies have found that the WHO vaccine selection strategy has not been effective in some years. This motivates the search for a better strategy for choosing vaccine …
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Can Plant Plastid Produce a Candidate Influenza Vaccine?
… flu pandemic highlights the obvious need for a vaccine against the influenza virus that is both inexpensive to produce and can be produced fast enough for development on a large scale. The influenza virus coat protein hemagglutinin (HA) is a major surface antigen and has emerged as a good …
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What influences Registered Nurses to have the influenza vaccine?
Influenza is a viral infection that can be spread from person to person by coming into contact with infected persons or objects that have been contaminated with the virus. The infection begins and the virus replicates in the ciliated columnar epithelial cells of the upper and lower respiratory …
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Cytokine-bearing Influenza Vaccine: Adjuvant Potential of Membrane-bound Immunomodulators
Influenza epidemics continue to cause morbidity and mortality within the human population despite widespread vaccination efforts. This, along with the ominous threat of an avian influenza pandemic (H5N1), demonstrates the need for a much improved, more sophisticated influenza vaccine. Our group has …
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Immune Response in Young Men to the 2014/15 Seasonal Influenza Vaccine
… the impact of adiposity and physical activity on influenza vaccination. The purpose of this pilot study was to investigate the role of adiposity and physical activity in the immune response of males aged 18-35 to the 2014/2015 seasonal trivalent influenza vaccine. Blood was drawn pre and four …
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Narcolepsy associated with Pandemrix influenza vaccine: A systematic review and meta-analysis
… between narcolepsy and the Pandemrix pandemic influenza vaccine. This particular association has been one of the most studied presumed vaccine adverse effects of the last decade and it has greatly affected the discussion on vaccine safety and vaccine hesitancy still to this date. Despite …
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Membrane-Bound Immunomodulators As Adjuvants In A Cell Culture-Based Avian Influenza Vaccine
<p>Inactivated viral vaccines often generate suboptimal immune responses. Adjuvants are incorporated into vaccines to increase their immunogenicity, however currently available adjuvants have shortcomings which have limited their use in human and veterinary medicine. This necessitates the …
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Improving the analysis of surveillance antigenic data to support seasonal influenza vaccine composition recommendations
Seasonal influenza is estimated to cause 3-5 million infections and 300,000-650,000 deaths worldwide per year. The main countermeasure is vaccination. As the virus evolves to evade the immune system, ongoing surveillance is required to determine if circulating viruses differ substantially from the …
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Knowledge and Perception of influenza vaccine among elderly residents in a selected village in Limpopo Province, South Africa
Background: Influenza is a very contagious respiratory illness caused by the influenza virus that mainly affects the nose, throat, and lungs, and it spreads through droplets released when an infected person coughs, sneezes, or speaks The influenza vaccine, often referred to as the “flu shot”, is …
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Effects of Psychological Stress on Glucocorticoid Sensitivity of Inflammatory Response to Influenza Vaccine Challenge in Healthy Military College Students
Background: Influenza and other infectious diseases are critical barriers to the health and readiness of military units worldwide with reported rates of annual influenza infection as high as 45%. Vaccination to prevent infections stimulates a transient, inflammatory response, counterbalanced by the …
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Supply chain coordination and influenza vaccination
Annual influenza outbreaks incur great expenses in both human and monetary terms, and billions of dollars are being allocated for influenza pandemic preparedness in an attempt to avert even greater potential losses. Vaccination is a primary weapon for fighting influenza outbreaks. The influenza …
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FMF assay for assessing vaccine generated antibodies in a biomimetic manner
… have been routinely used for assessing the vaccine response, since influenza vaccine has been administered in people (1940). Such assays are not always predictive regarding the protection conferred by the influenza vaccine and are not able to monitor neutralization related to stem region of …
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Evaluating the Target-Population Recommendations for Influenza Vaccination: Evidence and Ethics
The influenza virus infects between 5 and 10 percent of the population each year, resulting in acute respiratory illness ranging from subclinical to severe; during a pandemic, 50 percent of the population can easily be infected. Influenza infection creates serious social, economic, and public …
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High-Dimensional Covariate-Dependent Gaussian Graphical Models
… context. We apply our method to an influenza vaccine data set to model the gene network that evolves with time. We also investigate a Down syndrome data set to model the protein network, which varies with several covariates under a factorial experimental design. These applications …
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Process Intensification of Spodoptera frugiperda (Sf) Cell Growth via Multi-Parallel Bioreactor System
… process for the production of Flublok influenza vaccine, which was approved by the FDA in 2018. In short, Spodoptera frugiperda (SF+) insect cells are grown to a specific target cell density and then infected with baculovirus containing the gene of interest (GOI). For this particular …
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Improving pediatric influenza vaccination rates in the primary care setting
Background and Significance: Caregiver vaccine hesitancy (VH) is a barrier to pediatric health. Current pediatric vaccination rates nationwide fall below the national recommendations. Understanding contributors to individualized hesitancy while employing motivational interviewing (MI) techniques …
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Influenza : a study of contemporary medical politics
… prevention and control of seasonal and pandemic influenza has grown to be one of the largest and most visible public health policies. This dissertation considers contemporary influenza policy as a case study in what I call medical politics, in which a disease that for most people is rather …
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Comparative Statics Analysis of Some Operations Management Problems
… on the capacity investment decision and the influenza (flu) vaccine composition decision. Our approach involves exploiting the properties of the underlying mathematical models, and linking those properties to the concept of stochastic orders relationship. The use of stochastic orders allows …
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The State of T Cell Immunity against Influenza Virus in Humans and Exploration of Potential Strategies to Enhance Cell-Mediated Protection from Influenza Infection
… interest in developing a broadly efficacious influenza vaccine, as current antibody-eliciting formulations require annual re-immunization and are not effective in those most susceptible to influenza-related mortality. In contrast to antibody responses, influenza-specific CD8 T cells are …
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Tailored influenza virus vaccines for both the young and old: Vaccine Efficacy of Whole Inactivated Vaccines bearing Immunomodulatory Adjuvants or Multimeric peptides
Influenza epidemics and pandemics remain a significant burden to world health and economy. Low efficacy of current inactivated influenza vaccines in the elderly and immunocompromized and the inability to protect against antigenically drifted or shifted strains of influenza virus are the two major …
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