Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Influenza B"”.
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The role of the interaction of the influenza B virus NS1 protein with the cellular Brd2 protein
Influenza B virus is a major human pathogen causing highly contagious respiratory disease. It accounts for approximately ~30% of influenza virus infection per year. The effector domain of the NS1 protein of influenza B virus (NS1B protein), encompassing the carboxy terminal two thirds of the …
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The interaction between NS1B protein of influenza B virus and the ubiquitin-like modifier ISG15 : insights into a unique species specific property of the virus
Influenza B virus causes a respiratory disease in people with a compromised immune system. The NS1B protein of influenza B virus is essential for virus growth and plays a crucial role in inhibiting the anti-viral responses mounted by the infected host cell. The N terminal 104 amino acids of NS1B …
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Influenza Viral Protein Interaction Detecting Methods Development and A.M1-host Interplay Network Investigation
<p>The viral RNA-dependent RNA polymerases of influenza A and B are trimetric complexes (PA, PB1, and PB2 subunits), and are crucial for both transcription and replication of the viral genome. While there are extensive data on the structure and function of influenza A polymerase, the influenza B …
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Structure and dynamics of influenza M2 proton channels from solid-state NMR
The A and B strains of influenza virus places a substantial burden on health, causing around 30 million illnesses, several hundred thousand hospitalizations, and a few tens of thousands of deaths every year in the United States alone. Developing novel antiviral and vaccines against influenza …
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Investigation of Swine Influenza Virus Genetic Diversity and Evolution
<p>Influenza A exists primarily in a waterfowl reservoir and readily infects numerous avian and mammalian species. In swine, numerous subtypes and antigenic lineages of swine influenza virus (SIV) co-circulate. The reassortment of viral RNA segments in cells infected by multiple viruses can lead to …
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Development and Application of Solid-State NMR Methods for Investigating Protein Structure and Dynamics
… in solution compared to wild-type glucagon. The influenza matrix-2 protein (M2) conducts protons across the lipid membrane in the endosome and is essential for viral replication. Less is known about how the M2 protein of the influenza B strain (BM2) functions compared to AM2 and there are …
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Gripo ir ūminių viršutinių kvėpavimo takų infekcijų epidemiologiniai dėsningumai Lietuvoje 1997-2007 metais /
Research aim: to describe influenza and acute respiratory tract infections (ARI) epidemiological patterns in Lithuania 1997 – 2007. Method – to determine the dynamics of morbidity of influenza and ARI, it‘s distribution depending on age, gender, administrative territory and identify seasonal …
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Efficiency of Monoclonal Antibodies to Detect Respiratory Virus Antigens in Clinical Specimens
… epidemics of respiratory syncytial virus and influenza were observed. In contrast, parainfluenza and adenovirus infections occurred endemically throughout the study period. Children less than 6 years of age and adults greater than 50 years of age had the highest viral morbidity. Respiratory …
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A Role for Interferon Stimulated Gene-15 (ISG15) During Chikungunya Virus Infection
… shown to be essential for protection against influenza B and Sindbis virus infections. We demonstrate that neonatal ISG15<super>-/-</super> mice are profoundly more susceptible to CHIKV infection compared to WT mice. Unlike other viral models, mice lacking the ability to form ISG15 conjugates …
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Evaluation and adaptation of molecular approaches for detection and characterization of viruses of the respiratory tract
… MS2 RNA and tissue culture media positive for influenza B and hRSV. HRM analysis was also used for rapid and low cost detection of common pathogenic viruses of the respiratory tract. It is proposed that RT-Bst and RT-Bst SPA have the potential for sequence independent amplification of RNA …
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ISG15 conjugation : cellular targets and the lysine selectivity of HERC5
… it incapable of being re-conjugated, while the Influenza B NS1 protein binds and sequesters ISGylated proteins to block the anti-viral effect of ISG15 conjugation. HERC5 is the major ISG15 ligase in humans and targets hundreds of cellular and viral proteins for ISGylation. HERC5 associates with …
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Bacterial colonization of the nasopharynx in paediatric patients with acute respiratory viral symptoms
… pneumoniae, Staphylococcus aureus, Haemophilus influenzae or Moraxella catarrhalis. Co-colonization was common. H. influenzae isolates were non-typeable. S. pneumoniae was present in 33% of specimens combined for age and gender, with H. influenzae similar (34%), followed by S. aureus (25%) and …
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The development of a novel vaccine against avian influenza H7N9 virus
Influenza A viruses (IAV) are classified into the Orthomyxoviridae family and are composed of segmented, negative-sense, single-stranded ribonucleic acid (ssRNA) genomes in an enveloped particle. IAV is capable of infecting a wide variety of species, including but not limited to humans, birds, …