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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 89 for “"Influenza A virus"”.

  1. Influenza A Virus Induced Programmed Cell Death

    Shubina, MariaTemple University. Libraries2020

    Influenza A viruses (IAV) are negative sense RNA viruses that naturally infect a wide variety of animals. Different subtypes of the virus infect waterfowl, poultry, pigs, horses, ferrets, bats, dogs, cats and humans, causing zoonotic outbreaks and pandemics. In humans, IAV strains cause seasonal …

    temple Repository record

  2. Decoding aberrant RNA Synthesis by the Influenza A Virus

    Pitre, EmmanuelleUniversity of Cambridge2023

    Influenza A viruses (IAV) are negative-strand segmented RNA viruses and are responsible for causing severe respiratory diseases and fatalities in humans. IAV encodes an RNA-dependent RNA polymerase (FluPolA), which is responsible for transcribing and replicating each segment of the viral genome. In …

    cambridge Repository record

  3. Glycan receptor binding determinants of Influenza A virus hemagglutinin

    Koh, XiaoyingMassachusetts Institute of Technology2010

    … the factors involved in the human adaptation of influenza A viruses is critical for various aspects of influenza preparedness, including the development of appropriate surveillance measures, preventive strategies and effective treatments. A key step in influenza human adaptation is the …

    mit Repository record

  4. Characterization of influenza A virus evolution in laboratory hosts

    Davis, Kimberly RyanMassachusetts Institute of Technology2018

    Surveillance of influenza A virus (IAV) is conducted for many different hosts including humans, swine, poultry, and wild birds. The surveillance samples are screened by various methods, but ultimately the isolates that are positive for IAV are propagated in a laboratory host prior to genome …

    mit Repository record

  5. Airborne Transmission of Influenza a Virus in Indoor Environments

    Yang, WanVirginia Tech2012

    … know remarkably little about the dynamics of the influenza virus in the environment during transmission between hosts. There is still controversy over the relative importance of various transmission routes, and the seasonality of influenza remains unexplained. This work focuses on developing new …

    vt Repository record

  6. Interferons in Influenza A Virus and Streptococcus Pneumoniae Co-Pathogenesis

    Palani, Sunil 1992-The University of Texas Medical Branch at Galveston2024

    Secondary pneumococcal pneumonia postinfluenza significantly increases the disease burden associated with influenza A virus (IAV) infection. IAV induced interferons (IFN) play a crucial role in antiviral immunity. However, recent reports have indicated that influenza-induced IFN-I and IFN- γ …

    utmb Repository record

  7. Investigating the role of Sialoadhesin in Influenza A virus infection

    Ong, Ruo-YanUniversity of Dundee2020

    … mediate the uptake of a sialylated respiratory virus to initiate infection, it remains unclear if Sn will be able to recognize a pathogen devoid of terminal Sia, but triggers its upregulation through a type I IFN response. The aim of this thesis is therefore, to address Sn’s regulation of …

    dundee Repository record

  8. Influenza A Virus PB1-F2 Protein: its Role in Pathogenesis

    Deventhiran, JagadeeswaranVirginia Tech2015

    Influenza A virus (IAV) causes annual seasonal epidemics and occasional pandemics resulting in significant levels of mortality and socio-economic costs worldwide. PB1-F2 is a small non-structural protein encoded by an alternate +1 open reading frame in the PB1 gene. PB1-F2 is considered to play …

    vt Repository record

  9. Molecular biology of segment 8 of the influenza A virus genome

    Arikainen, ArturUniversity of Cambridge2022

    The single-stranded RNA genome of influenza A virus is divided into 8 segments, each of which encodes at least one polypeptide product. This work presents investigations into two aspects of the biology of the smallest (8th) segment: 1) a possible new gene product and 2) interactions of the viral …

    cambridge Repository record

  10. The Influenza A Virus NS1 Protein and Vriral mRNA Nuclear Export

    Fernandes Pereira, CarinaUniversity of Cambridge2018

    Influenza A virus (IAV) replication and transcription occur in the host cell nucleus; a feature which means both the viral genome (vRNA) and mRNA must be exported from the nucleus to the cytoplasm. The mechanism by which vRNA nuclear export is achieved has been well characterised, but how viral …

    cambridge Repository record

  11. Engineering and targeting glycan receptor binding of influenza A virus hemagglutinin

    Jayaraman, AkilaMassachusetts Institute of Technology2011

    The critical first step in the host infection by influenza A virus is the binding of the viral surface glycoprotein hemagglutinin (HA) to the sialylated glycan receptors terminated by N-acetyineuraminic acid (Neu5Ac) expressed on the host cell surface. Glycans terminating in Neu5Ac that is a2-6 and …

    mit Repository record

  12. Die Rolle des Transkriptionsfaktors NF-KappaB in Influenza-A-Virus infizierten Zellen

    Wurzer, WalterUniversität Würzburg

    … Infektionen, einschließlich der Infektion durch Influenza-A-Viren (Hiscott J. et al., 2001). Da die Expression vieler proinflammatorischer und antiviraler Zytokine, wie IFNb oder TNF-a durch NF-kB kontrolliert wird, hat sich ein Konzept entwickelt, welches besagt, dass NF-kB und sein …

    wurz-thes Repository record

  13. Immunologic And Biochemical Studies On The Influenza A Virus Nonstructural Protein (Ns1).

    Shaw, Michael William

    uab Repository record

  14. Dissecting mechanisms of intersegment epistasis and its role in influenza A virus biology.

    Diefenbacher, MeghanUniversity of Illinois at Urbana-Champaign2022

    Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-08-01

    uiuc Repository record

  15. The intracellular transport and cell surface expression of the influenza A virus M2 protein.

    Hughey, Patsy Grant

    uab Repository record

  16. A COHORT STUDY INVESTIGATING AUTOANTIBODY LEVELS DURING AND AFTER INFECTION WITH INFLUENZA A VIRUS

    Collins, Michelle2015

    … increase during or after infection with influenza A virus. Blood was collected from volunteers (n=11) at time intervals of 0, 7, 42 and 63 days, respectively. Antibody levels were measured using ELISA assays and ANA levels were measured using immunofluorescence (IF) techniques. Results …

    nmu Repository record

  17. Nicotin beeinflußt die durch Influenza-A-Virus induzierte Apoptose in humanen und caninen Zellen

    Kromeier, Jan

    … zum Ziel, die Auswirkungen von Nicotin auf die Influenza-A-Virus-induzierte Apoptose zu untersuchen. Zugrunde liegen zwei (in der Literatur vorbeschriebene und in eigenen Experimenten nachvollzogene) Tatsachen: <br> <br>1. Influenza-A-Virus induziert in infizierten Zellen Apoptose <br>2. Nicotin …

    freiburg-diss Repository record

  18. Investigating the mechanisms behind the immunostimulatory activity of influenza A virus RNA polymerase mutations

    Elshina, ElizavetaUniversity of Cambridge2022

    Activation of innate immune signalling during influenza A virus (IAV) infection is essential for the development of protective antiviral responses. However, uncontrolled release of proinflammatory cytokines is also associated with severe and fatal disease caused by highly pathogenic avian and …

    cambridge Repository record

  19. Interactions between influenza A virus and Streptococcus pneumoniae in nasal colonization and middle ear infection

    Wren, John ThomasWake Forest University2015

    … interest. Epidemiologically, coinfection with influenza A virus is strongly linked to the incidence of otitis media in children and experimental models have identified numerous mechanisms by which viral infection predisposes to increased pneumococcal infection. Unclear, however, are the roles …

    wfu Repository record

  20. Influenza A virus infection and innate immunity in an established murine alveolar-like macrophage model

    Wood, Connor2020

    Influenza is both a seasonal and occasional pandemic respiratory infection in humans, with the most vulnerable of society at the highest risk. With vaccine efficiency dropping and resistance against treatments, better understanding of the host-viral interactions is required to find novel therapy …

    plymouth Repository record

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