Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"Inflammatory stress"”.
-
Vitamin C and exercise-induced oxidative and inflammatory stress in ultramarathon athletes
Please read the abstract in the section 00front of this document
-
Citrobacter rodentium induced liver changes in C57BL/6 mice : animal model of acute inflammatory stress and injury
The activation of inflammatory responses, while critical for host defense, contributes to hepatic injury in numerous acute and chronic liver disease states as well as drug-induced liver injury (DILI). The interactions that mediate susceptibility to liver injury and disease, however, are still …
-
TEMPOL and Insulin Resistance: A study of the underlying mechanisms behind changes in glucose metabolism, lipid accumulation and cellular stress
… Overnutrition-induced obesity drives oxidative stress and inflammation, leading to insulin resistance. There are currently no successful treatments to treat insulin resistance or its downstream clinical sequelae. It was hypothesized that TEMPOL, a nitroxide, could suppress diet-induced insulin …
-
SIRT1 ACTIVATION IMPROVES HEART FUNCTION THROUGH INHIBITION OF INFLAMMATION IN CHAGAS DISEASE
… (CCM) is presented by increased oxidative/inflammatory stress and decreased mitochondrial bioenergetics. SIRT1 senses the redox changes and integrates mitochondrial metabolism and inflammation; and SIRT1 deficiency may be a major determinant in CCM. To test this, C57BL/6 mice were infected …
-
Mitophagy-Mediated Regulation of ROS Homeostasis During HSC Activation Contributes to Cell Fate
… basal physiologic conditions and in response to inflammatory stress. The degradative capacity of the autophagy-lysosomal system is a determinant of hematopoietic stem cell (HSC) activation status with low autophagy predicting activation of HSCs, and autophagy deficiency causing the spontaneous …
-
A Multi-Factorial Assessment of Partial Mitochondrial Complex I Impairment in Colorectal Cancer
… respiration is preferentially reduced, linking inflammatory stress to mitochondrial dysfunction that may predispose the colon to tumorigenesis. Timing-dependent experiments indicate that the stage at which complex I impairment occurs determines its pro-tumorigenic potential, consistent with …
-
Loss of rad51 in zebrafish (Danio rerio): a novel Fanconi anaemia model
… suppressor. I further demonstrate that prolonged inflammatory stress can exacerbate the haematological impairment, leading to an additional decrease in kidney marrow cell numbers. In contrast, prolonged aldehyde-derived stress did not induce symptoms in the mutant fish. These findings strengthen …
-
Molecular characterisation of the role of systemic infections in Alzheimer’s disease brain
… indicate that systemic infection amplifies neuroinflammatory and endothelial signalling already perturbed in AD, potentially compromising blood–brain barrier (BBB) integrity and facilitating peripheral–central immune crosstalk. Extending these analyses to microRNAs, small RNA sequencing …
-
Microrna 21 targets B Cell Lymphoma 2 (Bcl2) Mrna to increase beta cell apoptosis and exosomal Microrna 21 could serve as a biomarker of developing Type 1 Diabetes Mellitus
… (EV) beta cell-derived miR-21 may reflect inflammatory stress within the islet during T1D development.. Results suggest that beta cell miR-21 is increased in in-vivo models of T1D and cytokine-treated cells/islets. miR-21 overexpression decreased cell count and viability, and increased …
-
The role of the Dnmt3aR882H mutation in the evolution of clonal haematopoiesis.
… Long-Term Haematopoietic Stem Cells (LT-HSCs) to inflammatory "stress" in vitro and in vivo. We have also em- ployed bulk LT-HSCs genomics studies to interrogate differences in the transcriptional landscape in response to inflammation. We have demonstrated that Dnmt3a-mutant LT- HSCs have a …
-
Estrogen Modulation of Cardiac Immune Cells Is Cardioprotective.
… using a real time PCR array. A total of 55 inflammatory genes which were modified (> 2-fold change) at three days post-fistula was reduced to 20 genes by estrogen treatment, whereas 12 genes were comparably modulated in both fistula groups. In decreasing order, the greatest percentage of …
-
The influence of exercise training on the bone marrow microenvironment in obesity and cancer
… the bone marrow compartment and reversed the pro-inflammatory environment associated with obesity and CRC, thereby attenuating the persistent inflammatory stress to HSPCs. In the final section, we wished to establish if exercise would protect the BM and HSPCs from more direct stressors, and …
-
Soy isoflavones and swine health
… has found that pigs experiencing high levels of inflammatory stress performed better when fed greater amounts of soybean meal in the diet though it was unclear which component of this soy protein source was conferring these benefits. Among potential components, soy-derived isoflavones show …
-
The Role of Resveratrol and Sirtuin1 in Skeletal Muscle Under a Nutrient Stress
… indicated to be important in the presence of inflammatory stress (TNF-α) (Saini et al., 2012). Resveratrol supplementation has also improved survival and regeneration of skeletal muscle cells as well in muscle cell remodelling following oxidative stress (Bosutti and Degens, 2015). We therefore …
-
Discoveries of Targets and Novel Agents for the Treatment of Ischemic Retinopathy and Neovascular Disease
… </em>These results suggested that the reparative/inflammatory angiogenic response triggered by radiation could be blocked by targeting FA signaling, a central process of RNV progression in ischemic retinopathies. </p> <p>Findings in BXD studies linked tissue reparative processes involving …