Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"Inflammatory proteins"”.
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Discovery of novel anti-inflammatory proteins inspired by bone marrow mesenchymal stem cell secretions
… stem cell therapy for autoimmune and inflammatory disease. Our lab originally hypothesized that much of the therapeutic activity of MSCs may be attributed to molecules secreted by these cells. This thesis will test this hypothesis, with an emphasis on translational steps towards …
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Inflammatory Proteins, Genetic Variation, and Environmental Influences on Health Care Associated Infection Development in Sepsis
… impact of baseline systemic inflammation (pro‑inflammatory cytokine, anti‑inflammatory cytokine, and their ratio), genetic variability, and environment on the development of health care associated infections (HAI) among sepsis patients during their ICU stay (up to 28 days).</p> …
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Early biomarkers to predict grade of encephalopathy following hypoxic ischaemic injury
… Biomarkers studied included; multiple inflammatory proteins using multiplex assay; the metabolomics profile using LC/MS; and the miRNA profile using microarray. Results: Eighty five infants with perinatal depression were recruited. Analysis of inflammatory proteins consisted of …
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Antibody-modified conduits for extracorporeal selective cytokine filtration in sepsis
… bloodstream triggers the body to produce many inflammatory proteins, known as cytokines, that cause damage to blood vessels and vital organs. This leads to capillary leak, failing organs, and often death. We have developed a novel approach to modulate the inflammatory response, using …
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Peripheral Inflammation and Activity within Corticostriatal Reward Circuitry: Interactive Roles in Components of Anhedonia during Adolescence
… that there were nuanced associations of inflammatory proteins and reward-related brain function, independently and interactively, with anhedonia in adolescents. Specifically, distinct components of anhedonia (i.e., diminished anticipatory and consummatory pleasure, temporal discounting of …
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The Role of High Saturated Fatty Acid Diets on Skeletal Muscle Metabolism and Inflammation
… energy balance, and diet-induced agonism of pro-inflammatory pathways. A secondary aim was to determine if the metabolic adaptive response in skeletal muscle to a single, high fat meal was altered by 5 days of high saturated fat feeding. Twelve college-age, non-obese males were studied and …
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An Investigation of the Interplay Among CX3CR1, Immune Cells, and Gut Microbiota in Lupus-Associated Arthritis and Renal Disease using the MRL/lpr Mouse
… was found to influence the production of inflammatory proteins IL-17A and IL-17F, as well as the gut microbiota—bacteria living in the gut. The gut microbiota was observed to influence IL-17A but not IL-17F. When examining lupus-associated kidney disease and joint inflammation arthritis, …
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Calcitonin Gene-Related Peptide Promotes Peripheral and Central Trigeminal Sensitization
… determined changes in nocifensive behavior and inflammatory proteins. Intrathecal injection of CGRP increased nocifensive responses to mechanical stimulation up to 48 hours and this stimulatory effect was blocked by the antagonist peptide CGRP8-37 and a protein kinase A inhibitor. Results from …
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Functional neuroimaging studies of peripheral inflammation-related depression
… disorders with neuroimmunological or neuroinflammatory mechanisms, as well as peripheral systemic inflammatory disorders such as rheumatoid arthritis, psoriasis, and cancers. Recent research on the immune mechanisms of depression has reproducibly demonstrated a robust association between …
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The role of genetic factors and lifestyle relationship to obesity and metabolic syndrome in a sample of Bulgarian population // Проучване ролята на генетични фактори и начина на живот за изявата на затлъстяване и метаболитен синдром в извадка от българската популация
… disorders was provided. Therefore the anti-inflammatory activity of the medicinal plant Agrimonia eupatoria (agrimony) was studied. On the basis of the studies that scientific work has shown that obesity had polygenic nature. Carriage of a particular genotype may determine predisposition, …
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Determinants of systemic treatment response in atopic dermatitis
Atopic dermatitis (AD) is a common inflammatory skin disease characterized by intense pruritus and recurrent eczema. Its heterogeneous pathophysiology involves epidermal barrier dysfunction, immune dysregulation, and alterations of the skin microbiome. Despite major advances through targeted …
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Cellular immune mechanisms of psychiatric disorders and the stress response
… CD4+ T cells and monocytes, and increased inflammatory proteins. Depressed cases were partitioned into two subgroups by forced binary clustering of cell counts: the inflamed depression subgroup had increased myeloid and lymphoid cell counts, increased CRP and IL-6, and was more depressed …
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Human S100A8 and S100A9 Scavenge Pro-inflammatory Hypohalous Acids in Disease
… S100A9 and S100A12 are generally considered pro-inflammatory proteins because their expression is elevated in chronic inflammatory disorders. Hypohalous acids generated by activated phagocytes are scavenged by murine S100A8 and S100A9, suggesting a protective role in oxidative stress, but effects …
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THE ROLE OF CGI-58/ABHD5 IN LIPID METABOLISM, INFLAMMATION, AND INSULIN ACTION
… absence of CGI-58 decreased the activation of inflammatory proteins and increased the response to insulin in the liver. We discovered that CGI-58 is necessary for the generation of certain lipids that can act as signaling mediators of inflammation. Next, we tested whether CGI-58 is an activator …
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Obesity and cardiovascular disease. Aspects of methods and susceptibility.
… In a subcohort of 6193 men, information on inflammatory proteins was available. The Malmö Diet and Cancer Study included 28 098 men and women, with a mean follow-up of 7.6 years. National and local registers were used to follow the incidence of coronary events (CE), stroke and mortality. …
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The role of accelerated ageing in aberrant lung tissue repair and remodelling in COPD
… the ECM protein decorin and higher levels of pro-inflammatory protein secretion. Induction of cellular senescence in lung fibroblasts also resulted in ECM changes, secretion of pro-inflammatory proteins and impaired tissue repair functions of the fibroblasts. Furthermore, ASMCs had higher levels …
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The immunomodulatory effects of the garlic organosulfur compounds allicin and Z-ajoene in an in vitro murine model of LPS-induced inflammation
… we hypothesize that garlic OSCs modulate the inflammatory immune response by downregulating pro-inflammatory while stimulating anti-inflammatory responses, preventing the formation of a cancer-friendly chronic inflammatory environment. To test this hypothesis we established and optimised an in …
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The Effects of Macronutrient Composition on Oxidative Stress and Inflammation in Overweight and Obese Humans
… cells; however, there were no increases in any inflammatory proteins measured over the 6 h postprandial period. It is apparent that dietary macronutrients can influence factors associated with chronic disease in overweight and obese individuals. The evidence presented here may help to refine …
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Vascular breakdown in diabetic retinopathy: Role of connexin43 and possible interventions
… play a role in the pathogenesis of chronic inflammatory diseases and blocking these channels can alleviate vascular leak and inflammation associated with these conditions. However, there is conflicting literature with regards to connexin43 expression in DR. This is believed to be because …
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Describing the immune cell profile of ventricular cerebrospinal fluid (CSF) in paediatric central nervous system (CNS) infections
… to study, the unique characteristics of the neuroinflammatory response are poorly understood. A better understanding of the immune response to these infections could lead to improved host-directed therapies. An important method to study this is the analysis of infected ventricular cerebrospinal …
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