Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 517 for “"Inflammatory cytokines"”.
-
The Role of Gene Transcription and Inflammatory Cytokines in Bone Fracture Repair
… repair cascade. However, the production of inflammatory cytokines and recruitment of immune cells in the early stages of fracture repair, and the implications for these processes on effective fracture repair remain incompletely understood.For the first aim of the dissertation, we examined …
-
Behaviour of human myoblasts in vitro: role of ageing and inflammatory cytokines
… participants and treating them with recombinant cytokines.<br/>Several parameters were studied, but the main focus was on ability of myoblasts to proliferate and differentiate. Markers of proliferating muscle cells were desmin, NCAM and Ki67, and markers of differentiating muscle cells were …
-
Identification of the Pla2 Responsible For Prostanoid Synthesis in Response to Inflammatory Cytokines
… 50-60% of the PGE2 production in response to inflammatory cytokines. Thus, we hypothesized that a closely-related PLA2 is responsible for 40-50% of the PGE2 produced in response to inflammatory cytokines. To this end, we utilized RNAi technology, extensively optimized, to down regulate the …
-
Metabolism in Vascular Endothelial Cells: Effects of Hyperglycaemia, Pro-Inflammatory Cytokines and Polyphenols
… the deleterious effects of hyperglycaemic or inflammatory conditions on the vascular endothelium by modulating endothelial cell metabolism. Results: First, the effects of high-glucose concentrations, inflammatory cytokines and polyphenols on markers of endothelial cell function in HUVECs were …
-
Role of Activated Macrophages and Pro-Inflammatory Cytokines in Placental Trophoblast Invasion and Fetal Outcome
… also been linked to an increased presence of pro-inflammatory cytokine-secreting (activated) macrophages at the fetal-maternal interface. In particular, increased production of tumour necrosis factor-alpha (TNF) by activated macrophages has been implicated as a causative factor mediating various …
-
Potential influence of blueberry and black raspberry pomace phenolics on inflammatory cytokines in coronary cells
… are known risk factors associated with chronic inflammatory conditions including cardiovascular inflammation and thus cardiovascular disease (CVD), the leading cause of death in the US. Anthocyanins from berries have the potential to provide protection against inflammation in various tissues; …
-
Effects of vitamin D on pro-inflammatory cytokines associated with Non-alcoholic fatty liver disease
… in NAFLD. Vitamin D is recognized for its anti-inflammatory and anti-proliferative properties and mediates these functions through regulating and interrelating with inflammatory cytokines. We hypothesize that vitamin D may regulate gene expression by methods that would resolve ongoing …
-
Attenuated Responses To Inflammatory Cytokines In Mouse Embryonic Stem Cells: Biological Implications And The Molecular Basis
… responses to viral/bacterial infections and inflammatory cytokines. Inflammatory conditions generally inhibit cell proliferation, which could be detrimental to ESCs, since cell proliferation is their dedicated task during early embryogenesis. Thus, I hypothesize that the attenuated innate …
-
In vitro models of cartilage degradation following joint injury : mechanical overload, inflammatory cytokines and therapeutic approaches
… but the elevated levels of injury-induced pro-inflammatory cytokines, such as TNFa and IL-6, have been implicated to play important roles in the pathogenesis of OA. We have used in vitro models of cartilage injury to examine the interplay between mechanical and cytokine-mediated pathways and to …
-
Physical activity for health: the impact of exercise on the human gut microbiota and pro-inflammatory cytokines
… of Exercise Medicine, centred on 1) the antiinflammatory effects of exercise and 2) the impact of exercise and associated diet on the intestinal microbiota. To do so we used a combination of systematic review, randomized control trials, and prospective observational analyses. Results: …
-
A quantitative proteomics study of the additive effect of inflammatory cytokines and injurious compression on cartilage damage
… conditions, and proteins on which injury and cytokines acted synergistically identified. PLSR analysis was performed using Unscrambler®X software with the combined data set to determine which proteins are most relevant to some observed phenotypes. The phenotypes chosen were sGAG released to …
-
Regulation of human satellite cells in vitro via inflammatory cytokines and myogenic transcription factors across proliferation and differentiation
… not fully understood. Recent characterization of cytokines secreted by skeletal muscle in an endocrine type fashion has led to discoveries of inflammatory cytokines influencing satellite cell function. However, how the autocrine production and secretion of these cytokines during proliferation and …
-
Regulation of Human Renal Drug Transporters by Inflammatory Cytokines and Pregnancy-related Hormones in Primary Proximal Tubular Epithelial Cells
… is characterized by elevated circulating pro-inflammatory cytokines, whereas pregnancy is accompanied by a distinct endocrine milieu with increased concentrations of multiple pregnancy-related hormones (PRHs). These soluble mediators are well known to regulate hepatic drug metabolizing enzymes …
-
Use of Cholera Toxin B as a Vaccine Adjuvant Activates Antigen Presenting Cells and Stimulates Production of Pro-Inflammatory Cytokines
… express costimulatory molecules, and produce pro-inflammatory cytokines. We found that RAW264.7 cells, a murine macrophage cell line, responded to treatment with <em>iFt+CTB</em> by an increased secretion of the pro-inflammatory cytokines IL-6 and TNF-α. It was also determined that treatment with …
-
Effects of pelvic 3D-CRT versus IMRT radiation therapy on circulating pro-inflammatory cytokines in high risk Prostate Cancer patients
… therapy on the levels of circulating pro-inflammatory cytokines (cPIC) in high-risk prostate cancer patients, who received pelvic radiation therapy delivered either by 3-dimensional radiation therapy pelvic (3D CRT) or intensity-modulated radiation therapy (IMRT). Subjects included 90 …
-
Mechanical injury and inflammatory cytokines affect cartilage integrity and tissue homeostasis : a mass spectrometric analysis of proteins with relevance to arthritis
… cytokine-induced inflammation. While the role of inflammatory cytokines in OA is still controversial, their role in rheumatoid arthritis is evidenced by the successful use of anti-TNF-ca and anti-IL-1 therapies to abrogate disease symptoms and progression. In vitro, both IL-13 and TNF-ca promote …
-
The Association Between Pro-Inflammatory Cytokines and C-Reactive-Protein and the Cognitive and Neurological Outcome in Stroke Survivors: A Systematic Review
… has thoroughly examined the association between inflammatory markers and neurocognitive outcome post-stroke. Our main goal was to examine the existing literature and this association between inflammatory markers and post-stroke functioning, primarily by examining the tools and methods chosen by …
-
Exercise-induced alterations in melanocortin receptor expression and inflammation
<p>Inflammatory cytokines play a significant role in the pathogenesis of obesity-related diseases and have been implicated as integral factors in both early and late phases of atherosclerosis. Lifestyle modifications such as increasing physical activity and making dietary changes to induce weight …
-
Substance P And The Host Immune Response
… by macrophage-specific upregulation of pro-inflammatory cytokines, downregulation of anti-inflammatory cytokines, and upregulation of anti-apoptotic genes, as well as a decrease in arginase-producing macrophages (M2 cells), important in stromal healing in these mice. All of these lead to …
-
Investigating the immune modulatory properties of kisspeptin: implications for pregnancy
… been implicated in the regulation of specific cytokines during pregnancy. It is crucial to maintain an appropriate cytokine balance at the maternal– fetal interface as well as in circulation. Several pregnancy-related disorders have been associated with a variation in Th1/Th2/Th17 cytokines and …
Page 1 of 26