Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Inflammatory arthritis"”.
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Investigations into the immunopathology of inflammatory arthritis
… volume contains an introduction to the topic of inflammatory arthritis, followed by Chapter 2 which is a Materials and Methods section and includes experimental protocols used for the original research detailed in Chapters 3 to 6 (Sections 2.1 - 2.4). Chapters 3 to 6 are each followed by their …
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Co-designing the inflammatory arthritis self-management (aiM) intervention.
… an integral part of care for people living with inflammatory arthritis. The benefits of self-management interventions for people living with long-term conditions are well established. To date, most of the inflammatory arthritis self-management interventions have targeted only rheumatoid …
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Team rehabilitation and health care utilization in chronic inflammatory arthritis patients
… programmes in patients with chronic inflammatory arthritis (CIA); rheumatoid arthritis (RA), ankylosing spondylitis, psoriatic arthritis and other spondyloarthritides, and to analyse health care utilization over the last decade in patients with RA. In Study I the outcome of an 18 days …
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Metabolism and Body Composition in Chronic Inflammatory Arthritis: Prevention and Intervention through Pharmaceutical and Physical Means
Background: Rheumatoid arthritis (RA) is characterised by excessive production of tumour necrosis factor alpha (TNFα). This leads to rheumatoid cachexia, a condition characterised by increased resting energy expenditure (REE) and loss of fat-free mass (FFM) leading to functional disability, …
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Runx1 in Primitive Hematopoiesis and Characterization of Hematopoietic Stem Cells in a Mouse Chronic Inflammatory Arthritis Model
… adulthood. By utilizing mice undergoing chronic inflammatory arthritis, we investigated the relationship between hematopoiesis and bone homeostasis in pathological conditions. We demonstrated that mice with chronic inflammatory arthritis are osteoporotic due to a severe defect in osteoblast …
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Radiological features of psoriatic arthritis
Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis. Psoriasis is a dermatological condition that affects 1-2% of the population. Approximately 10-15% of patients with skin manifestations of psoriasis develop PsA and 0.3-1% of the general population. Moll and Wright …
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Improving the outcome of psoriatic arthritis
Psoriatic arthritis (PsA) is recognised to have a significant impact on functional impairment, joint damage and quality of life. The aim of this thesis was to investigate tools for early identification, to develop a clinical target for treatment and to utilise these tools within a clinical trial. …
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The Messiness Within: Personal Essays on Peeling Back the Facade
… chronic illness—namely Crohn’s disease and inflammatory arthritis—into my quotidian life from childhood on. And the final essay investigates my sense of identification with my grandmother, Edith Lansky, whose life was characterized by a desire to repress pain and escape into art and beauty. …
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Reengineering a human-like uricase for the treatment of gout
… need in the treatment of gout. This type of inflammatory arthritis can be efficiently alleviated by the enzyme uricase. This enzyme breaks down uric acid, the causative agent of gout, so it can be flushed from the body. In humans and the other great apes, uricase is a pseudogene and as such …
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Environmental and Genetic Factors Affecting Bone Diseases and Phenotypes in Mouse Models
… exhibited susceptibility to spontaneous arthritis disease (SAD), while those of a DBA/1 background were resistant to developing SAD. Our progress on the study of SAD suggested that some of the bone phenotypes, BMD, BV, tibia length, and cortical thickness, were different between wildtype …
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Defining the Role of CD3 Zeta ITAMs in T Cell Signaling and Development
… are thought to be critical for the prevention of inflammatory arthritis following infection with the spirochete, Borrelia burgdorferi. Despite significantly reduced iNKT cells in the CD3 zeta ITAM mutant mice, there was no difference in the severity of Lyme arthritis in these mice compared to wild …
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Investigation of the synovial tissue-homing mechanisms of circulating mononuclear phagocytes in treatment-naïve psoriatic arthritis.
Psoriatic arthritis (PsA) is a common immune-mediated chronic inflammatory arthritis (IA) with no existing biomarker and is associated with permanent joint damage and significant sequelae. A key feature is abnormal recruitment of leukocytes into joint tissues and increased vascularisation that …
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Psoriatic arthritis and psoriasis : the role and impact of psychosocial factors
… with the psychosocial impact of psoriatic arthritis (PsA) - an inflammatory arthritis associated with psoriasis. Although an extensive literature exists on the nature and impact of psoriasis, little is known about the effect that psoriatic arthritis can have on an individual, and the …
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Anti-TNF treatment of chronic arthritis in clinical practice. New assessment method and predictors of efficacy and tolerability.
Abstract Treatment of chronic inflammatory arthritis has undergone major changes over the past years following introduction of targeted biological therapies. Tumour necrosis factor (TNF) blocking therapy has been the most important biological treatment of chronic arthritis to date. The overall …
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The gut microbiota in immune-mediated disorders
… conditions such as osteoporosis, inflammatory arthritis, inflammatory bowel disease (IBD) and multiple sclerosis. This thesis provides further understanding of the changes in the gut microbiota dynamics in these disorders which is important for establishing a necessary knowledge …
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Osseointegration of a Cementless Total Knee Arthroplasty in a Murine Model of Glucocorticoid Induced Osteoporosis
… steroids (GC) are used long-term typically for inflammatory diseases such as rheumatoid arthritis, lupus, multiple sclerosis, and other autoimmune disorders. Inflammatory arthritis often leads to joint replacement at relatively young ages. However, patients who are on GC treatment appear to have …
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DRUMBEAT© for arthritis “ a shared purpose” rather than a “lonely struggle”
… living with one or more chronic conditions, with arthritis and other musculoskeletal (MSK) conditions representing the most expensive chronic disease group in Australia. As the leading cause of chronic pain and second most common cause of disability and early retirement due to ill health in …
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Genetic Exploration of Hereditary Immune Diseases
… 80 types of autoimmune diseases, rheumatoid arthritis and systemic sclerosis are two of them. My study focuses on these two diseases. Our hypothesis is that mutated genes lead to autoimmune diseases that cause the immune system to attack the human body. The mutated genes cause the gene …
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REGULATION AND EXPRESSION OF AMYLOID CURLI IN SALMONELLA INFECTION
… autoimmune responses within the host. Reactive arthritis (ReA) is a painful form of inflammatory arthritis that can develop following gastrointestinal infections. The mechanisms of how enteric pathogens induce ReA are not known; however, curli fibrils are highly conserved in enteric bacteria and …