Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Inflammatory Monocytes"”.
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Lifestyle and exercise effects on circulating progenitor cells in children and adults
… inflammation characterized by elevating inflammatory proteins and a chronically activated immune system, which is maintained by circulating progenitor cells (CPCs). CPCs are a heterogeneous population of cells that are capable of replenishing the immune system after a hematopoietic stem …
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Dose-dependent effects of endotoxin on monocyte and the underlying mechanisms
Monocytes are dynamic innate immune cells that respond differently based upon the dose and duration of an infection. While super low dose endotoxin is found in chronic inflammatory diseases such as atherosclerosis, exposure to high dose endotoxin leads to sepsis. However, clear characterization of …
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HDAC6 Deletion Decreases Pristane-Induced Inflammation and Lupus
… promoted the population of CD11b+Ly6C++ inflammatory monocytes and CD11b+Ly6G+ neutrophils. Peritoneal recruitment of these inflammatory monocytes and neutrophils in HDAC6-/- mice was significantly decreased compared to the WT mice. Pristane treatment also induced the interferon (IFN) …
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Investigating the antibody-independent functions of B lymphocytes
… a systemic response in which neutrophils and inflammatory monocytes are mobilised from the bone marrow to the injured kidney. We found that during murine models of AKI, neutrophils exit the bone marrow and increase in the blood and kidneys. This neutrophil mobilisation was tightly correlated …
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The role of autophagy in protecting periodontium integrity, and lipopolysaccharide-induced osteoclast differentiation
… outcome are orthodontic tooth movement and inflammatory-induced periodontal disease. This thesis aims to investigate the hypothesis that autophagy is involved in bone remodeling during orthodontic tooth movement and periodontal disease. While the stem cells concerned in both osteogenesis and …
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Characterization of pattern recognition receptor responses against materials for cell encapsulation
… system and implanted islet cells. However, inflammatory monocytes and macrophages initiate a cascade of immunological responses to the implanted materials, leading to a chronic inflammation that results in fibrosis of the implants and hypoxic death of the islet cells. These macrophages may …
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Characterisation of a novel leukocyte receptor complex-encoded receptor TARM1
… by myelocytes, mature neutrophils and inflammatory monocytes and TARM1+ cells were rapidly recruited to sites of inflammation. TARM1 expression was also upregulated by bone marrow–derived macrophages and dendritic cells following stimulation with TLR agonists in vitro. Ligation of the …
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Exploring antiviral effector cells in vaccinia virus-infected tissues
… into the dermis and eliminate VACV- infected inflammatory monocytes. During the course of infection, VACV replication leads to a marked increase in the permeability of local blood vessels that occurs prior to the entry of CD8+ T cells. Pharmacological Inhibition of VEGF receptor …
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Fibroblasts: Key Cells in Inflammation and Fibrosis
… abdominal aortic aneurysm (AAA). IL-6 is a pro-inflammatory cytokine that is secreted by fibroblasts and macrophages in the aortic adventitia and promotes the development of aortic dissections. In our previous work, analysis of aortic adventitial fibroblast secretions in vitro suggested that …
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The Role of miR-126/126* in Microenvironmental Regulation of Cancer Metastasis
… recruitment of mesenchymal stem cells (MSCs) and inflammatory monocytes into the primary tumour stroma, consequently inhibiting lung metastasis by breast tumour cells. Mechanistically, these miRNAs directly inhibit the production of stromal cell-derived factor-1 alpha (Sdf-1α, also known as …
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Investigating the role of the Dendritic Cell Immunoactivating Receptor in the Immune Response during Pneumocystis murina
… hematologic malignancies, organ transplant, inflammatory disorders and pre-existing lung disease. Immediate immunity is initiated by receptors that recognize pathogen associated molecular patterns on the surface of pathogenic fungi. Specifically, C-type lectin receptors (CLRs) have been shown …
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The neonatal anti-viral response fails to control measles virus spread in neurons despite interferon-gamma expression and a Th1-like cytokine profile
… natural killer cells, neutrophils, infiltrating monocytes and T cells in an IFNg-independent manner, all of which are capable of contributing to the IFNg pool. However, neonates and adults differentially express pathogen recognition receptors (<em>e.g.</em> Toll-like receptors) and Type I …