Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Inflammasomes"”.
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Inflammasomes in the Intestinal Epithelium
Inflammasomes are multiprotein signalling complexes that detect a diverse range of pathological stimuli to activate inflammatory caspases, resulting in cell death and the release of IL-18 and IL-1. Inflammasomes are important in a wide range of diseases, in particular with auto-inflammatory …
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Interferon-Inducible GTPases as Positive and Negative Regulators of Inflammasomes
… in promoting activity of a set of PRRs known as inflammasomes, which not only sense pathogens but also directly produce pro-inflammatory cytokines. I first explore this observation in the context of chlamydial infection. Using a macrophage cell culture model, I demonstrate that GBPs are essential …
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The role of inflammasomes in a murine model of acute respiratory distress syndrome (ARDS)
… player in lung injury progression. Importantly, inflammasomes have been shown to have roles in microbial clearance and neutrophil recruitment as part of the host defence against bacterial or viral infections. However, the contribution of inflammasome<br/>activation and the inflammasome-activated …
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The role of NLRP3 and AIM2 inflammasomes in dental pulp inflammation and reparative processes
… 2 (AIM2) and Nod-like receptor protein 3 (NLRP3) inflammasomes is yet to be elucidated. <br/><br/>In this thesis, the role of AIM2 and NLPR3 receptors was explored, both in bacterial and sterile inflammation context. Furthermore, the potential of modulating the inflammatory responses via these …
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Exploring new regulators of innate immune signalling pathways with a particular focus on inflammasomes
Inflammasomes are innate immune signalling complexes vital in the activation of caspase-1, inflammation and wound healing. The dysregulation of inflammasome activity has been linked to the development of autoinflammatory diseases. Recently, the role of post-translational modifications has been …
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Examining the Role of Non-Canonical NOD-like Receptors and Inflammasomes in Inflammation and Disease
… complexes. Interestingly, not all inflammasomes are nucleated by NLRPs. The recently characterized non-canonical caspase-4 (caspase-11 in mice) inflammasome is known to be a key driver of the innate immune response to intracellular pathogens (and the molecules associated with them), …
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Rodent inflammasome activation by Toxoplasma gondii
… Here, we report that Toxoplasma activates the inflammasomes in mice and rats. The inflammasomes are a set of cytoplasmic pattern recognition receptors (PRRs). Activation of the inflammasomes results in caspase-1 activation and the cleavage and release of the pro-inflammatory cytokines, …
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Expression of inflammasome-related molecules from U87MG cells cocultured with Naegleria fowleri in the non-contact system
… (PAM) in experimental animals and in humam. Inflammasomes are large intracellular multiprotein complexes that play a central role in innate immunity. They detect and respond to a large range of pathogen-associated molecular patterns (PAMPs), including bacterial flagellin, and …
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The effects of E-cigarettes on pulmonary inflammation and inflammasome activation
… generation. Inflammatory complexes called the inflammasomes are known to initiate and potentiate inflammation and are classically activated by two signals, usually a PAMP (Pathogen Associated Molecular Pattern) and a DAMP (Danger Associated Molecular Pattern) which result in the processing of …
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Battling Bacteria: Characterizing the NOD-Like Receptor (NLR) Immune Response to <i>Brucella abortus</i> and <i>Borrelia burgdorferi</i> in Host-pathogen Interactions
… inflammation. Here, we investigated the roles of inflammasomes and negative regulatory NLRX1 in response to bacterial diseases. First, we studied brucellosis, a zoonotic, chronic disease often transmitted in unpasteurized dairy products from livestock. Using murine models and bone marrow-derived …
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Caspase isoforms in inflammasome activation
Inflammasomes are macromolecular signalling platforms composed of a receptor (for example NLRP3 or NLRC4), an adaptor (ASC) and effectors (caspases) that are thought to play critical roles in the host defence against microbial infections. Activation of inflammasomes leads to the processing of the …
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The Activation of the Inflammasome during Rickettsial Infection
… (LPS) of caspase-11 and ASC-dependent inflammasomes in macrophages is essential for host clearance of rickettsia through mediating the secretion of IL-1β, IL-18, and induction of pyroptosis. Specific Aim 1 focuses on the role of caspase-11-dependent inflammasome activation in host …
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Role of the NLRP3 Inflammasome in bacterial keratitis
Purpose: Inflammasomes are key molecular regulators that play important roles in inflammation. Studies have reported that the NLRP3 inflammasome is activated in response to infection with Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus). However, the role of NLRP3 …
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Elucidating Human Inflammasome Responses To Legionella Pneumophila And Lipopolysaccharide Variants
… of the both the noncanonical and canonical inflammasomes. Specifically, a family of IFN-inducible GTPases known as guanylate binding proteins (GBPs) promote inflammasome responses to a variety of bacteria in mice. The functions of the mouse GBPs include stimulating the rupture of …
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A Non-Canonical Function for NLRP3 and AIM2 in Kidney Diseases
… studied in leukocytes. Canonical NLRP3 or AIM2 inflammasomes regulate cytokine maturation and pyroptosis via ASC and caspase-1 activation. Emerging studies demonstrate that NLRP3 or AIM2 is expressed in non-haematopoietic cells such as tubular epithelial cells (TEC) in the kidney. The central …
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Toll Like Receptor Dependent Control of T Helper 17 Cell Differentiation and Inflammasome Activation
… and tissue injuries trigger the assembly of inflammasomes, cytosolic protein complexes that activate caspase-1 leading to cleavage of pro-IL-1β/pro-IL-18, and pyroptosis, a pro-inflammatory cell death program. Although microbial recognition by Toll-like receptors (TLR) induces synthesis of …
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OROPOUCHE VIRUS DISRUPTION OF HOST CELL FUNCTIONS: PYROPTOSIS INDUCTION AND TRANSCRIPTIONAL SUPPRESSION
… role in the febrile response and is regulated by inflammasomes, such as NLRP3. This dissertation demonstrates that macrophages, but not monocytes, are permissive to OROV infection and undergo pyroptosis through the activation of caspases-1, -3, and -8, leading to the cleavage of Gasdermin D …
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Molecular basis of NAIP/NLRC4 inflammasome activation by flagellin
… immune response against salmonellosis. Inflammasomes are multi-protein complexes formed in response to the activation of pattern recognition receptors (PRRs). The NOD-like receptor (NLR)-family of inflammasome complexes are formed from the cytosolic NLR receptors, ASC adaptor and …
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The Role of Human Guanylate Binding Proteins in Host Defense and Inflammation
… (caspase-1) and noncanonical (caspase-11) inflammasomes. However, whether these functions are conserved among the human orthologs of murine GBPs has remained unclear. </p><p>To determine whether the ability to physically target pathogens is conserved among the human GBPs, I monitored the …
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Intracellular triggering of inflammation by the extracellular bacterium Pseudomonas aeruginosa
… protein complexes, the Nod-signalosome and inflammasomes. These lead to the activation of NF-κB and the activation of caspase-1 and subsequent proteolytic processing of interleukin-1β (IL-1β) into its mature form. Both processes contribute to the inflammatory response following infection. In …
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