Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 101 for “"Inflammasome"”.
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Caspase isoforms in inflammasome activation
Inflammasomes are macromolecular signalling platforms composed of a receptor (for example NLRP3 or NLRC4), an adaptor (ASC) and effectors (caspases) that are thought to play critical roles in the host defence against microbial infections. Activation of inflammasomes leads to the processing of the …
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Inflammasome signalling during Salmonella Typhimurium infection
… infection, leading to formation of the inflammasome. The inflammasome is a macromolecular complex assembled in the cytoplasm, and usually contains a NLR, the structural protein apoptosis-associated speck-like protein containing a CARD (ASC) and effector enzymes such as cysteine-dependent …
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Rodent inflammasome activation by Toxoplasma gondii
… Here, we report that Toxoplasma activates the inflammasomes in mice and rats. The inflammasomes are a set of cytoplasmic pattern recognition receptors (PRRs). Activation of the inflammasomes results in caspase-1 activation and the cleavage and release of the pro-inflammatory cytokines, …
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Transcriptional Regulation of NLRC4 Inflammasome by IRF8
<p>The NLRC4 inflammasome is a crucial part of the innate immune response against bacterial infections. We found that NLRC4 inflammasome activation in bone marrow-derived macrophages (BMDMs) is greatly dependent on interferon regulatory factor 8 (IRF8). NLRC4-mediated caspase-1 activation and …
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Fatty Acid Regulation of NLRP3 Inflammasome Activity
… inflammation that is driven in part by the NLRP3 inflammasome. This macromolecular complex responds to diverse danger signals by inducing secretion of inflammatory IL-1 family cytokines and promoting a type of cell death called pyroptosis. Saturated fatty acids (SFAs) are known to activate the …
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The Activation of the Inflammasome during Rickettsial Infection
… investigated the canonical and non-canonical inflammasome activation by rickettsiae in mouse macrophages. The central hypothesis is that activation and priming by lipopolysaccharide (LPS) of caspase-11 and ASC-dependent inflammasomes in macrophages is essential for host clearance of rickettsia …
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Role of the NLRP3 Inflammasome in bacterial keratitis
Purpose: Inflammasomes are key molecular regulators that play important roles in inflammation. Studies have reported that the NLRP3 inflammasome is activated in response to infection with Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus). However, the role of NLRP3 …
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The role of PLK1 in NLRP3 inflammasome activation
The NLRP3 inflammasome is a heteroprotein complex that assembles in response to a variety of DAMPs (Damage-Associated Molecular Patterns) and PAMPs (Pathogen-Associated Molecular Patterns). Activation of the NLRP3 inflammasome leads to pro-inflammatory cytokines (IL-1 and IL-18) release and …
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Molecular basis of NAIP/NLRC4 inflammasome activation by flagellin
… (S. Typhimurium) activates the NAIP/NLRC4 inflammasome and its contribution to the host protective immune response against salmonellosis. Inflammasomes are multi-protein complexes formed in response to the activation of pattern recognition receptors (PRRs). The NOD-like receptor …
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The PLK1 and NLRP3 interactome in NLRP3 inflammasome activation
Excessive activation of the NLRP3 inflammasome is involved in sterile inflammation in multiple chronic diseases such as atherosclerosis, gout, type 2 diabetes or Alzheimer’s disease. However, current treatment strategies using generic targeting of IL-1, the end product of multiple inflammasome …
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Elucidating Human Inflammasome Responses To Legionella Pneumophila And Lipopolysaccharide Variants
… formation of a multiprotein complex termed the inflammasome, which leads to the recruitment and activation of inflammatory caspases. These caspases promote IL-1 family cytokine release and pyroptosis, a lytic form of cell death, which are critical for anti-bacterial defense. In mice, …
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Investigating the Contribution of the Inflammasome to Persistent Pain States
… of this enzyme requires assembly of the inflammasome, a multi-protein complex. The active complex contains a central scaffold protein (eg nod-like receptor-1 (NLRP1), NLRP3), the adaptor protein apoptosis-associated speck-like protein containing a CARD (ASC), and pro-caspase-1. It is …
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Exploring the Role of the Inflammasome Pathway in Diabetic Retinopathy
… domain (NOD)-like receptor protein 3 (NLRP3) inflammasome activation, which orchestrates inflammation in the innate immunity, is associated with DR. However, the impact of inflammasome activation on DR progression remains uncertain. Therefore, this thesis seeks to investigate the role of …
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Expression and function of the NLRP3 inflammasome in Behçet’s disease
… 주장이 제기되고 있다. 최근 그람 음성균 감염 후 발생한 구내염 환자에서 NLRP3 inflammasome를 매개로 한 전신 염증의 가능성이 보고 되고 있으나 아직까지 베체트병에서 NLRP3 inflammasome의 역할에 대한 연구는 되어 있지 않다. 연구목적:이 연구는 베체트병에서 NLRP3 inflammasome 단백질의 발현 및 mRNA 의 발현을 말초혈액단핵구에서 확인하고 또한 LPS 와 ATP 자극에 따른 IL-1β 의 발현 양상을 알아보고자 했다. 재료 및 방법:활동성 베체트병 환자 (15명), 비활동성 베체트병 …
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The effects of E-cigarettes on pulmonary inflammation and inflammasome activation
… generation. Inflammatory complexes called the inflammasomes are known to initiate and potentiate inflammation and are classically activated by two signals, usually a PAMP (Pathogen Associated Molecular Pattern) and a DAMP (Danger Associated Molecular Pattern) which result in the processing of …
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Inflammasome mediated response to biomaterials implanted in the peripheral nervous system
… demonstrated the potential role of IL1b and the inflammasome in the treatment of FBR. Using in vivo knock-out models of the inflammasome, I have shown: reduction in the expression of molecules involved in inflammation and fibrosis (using RT-qPCR); reduction in scar thickness and increase in …
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The Role of NLPR3 Inflammasome in Response to Thermal Injury and Sepsis
… risk of infection and sepsis. The NLRP3 inflammasome has established itself as an integral mediator of the acute phase response, however there is a current lack of understanding how it is involved in the inflammatory response after burn injury. In this study we investigated the role of …
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Dendritic Cells Suppress Pathogen-Induced Inflammasome Activation to Prime Naïve T Cells
Activation of inflammasome leads to pyroptotic cell death thereby eliminating the replicative niche of virulent pathogens, a process integral to innate immunity. While inflammasome-associated cytokines such as IL-1β and IL-18 have an established role in T cell function, whether inflammasome …
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Particulates Initiate Immune Response Via Inducing Oxidative Stress-Mediated NLRP3 Inflammasome Activation
… I hypothesize that liposomes activate NLRP3 inflammasome in macrophages, which results in the release of interleukin 1β (IL-1β), a proinflammatory cytokine that plays a key role in innate and adaptive immune responses.</p><p>To test my hypothesis, I determined the ability of inducing IL-1β …
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