Global ETD Search
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Showing 1 to 18 of 18 for “"Infective endocarditis"”.
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The changing landscape of infective endocarditis in South Africa
… clinical profile and outcomes of patients with infective endocarditis (IE) in South Africa. Methods. We conducted a retrospective review of the records of patients admitted to Groote Schuur Hospital between 2009 and 2016 fulfilling universal criteria for definite or possible IE, in search of …
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Infant and Childhood Infective Endocarditis in the Western Cape, South Africa: A Retrospective Review
Introduction Infective endocarditis is a microbial infection of the endothelial surface of the heart, predominantly the heart valves, that is associated with high mortality and morbidity. Few contemporary data exist regarding affected children in our context. Aims and Objectives: We aimed to …
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Profile, Presentation and Outcomes of Prosthetic Valve Endocarditis in a South African Tertiary Hospital: Insights From the Groote Schuur Hospital Infective Endocarditis Registry
Background Prosthetic valve infective endocarditis (PVE) is associated with high morbidity and mortality. The prevalence of PVE in local retrospective studies ranges between 13% and 16%. However, the clinical patient profile and outcomes remains unknown. Methods We performed a prospective …
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Long term outcome and the validity of EuroSCORE II in native-valve surgery for active endocarditis in a South African cohort
Infective endocarditis was initially described in the early 16th century and only methodically reviewed after the 19th century when Osler gave the drive to the Royal College of Physicians in 1885 through his contribution. The last 25 years has not shown much change in the mortality from infective …
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The clinical utility of tissue polymerase chain reaction, tissue culture, and tissue histology in blood-culture negative infective endocarditis - a South African single hospital experience
Background. Infective endocarditis (IE) poses significant diagnostic and therapeutic challenges, especially in blood culture-negative infective endocarditis (BCNIE) cases. Appropriate antimicrobial therapy is guided by knowledge of the causative organisms and their characteristics. Amongst patients …
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Haemorrhage and Other Complications in Pregnant Women on Anticoagulation for Mechanical Heart Valves; a Prospective Observational Cohort Study
… transfused, six major haemorrhages, one case of infective endocarditis and three ischaemic strokes. Ten pregnancies had poor foetal outcomes (six miscarriages, three terminations, one early neonatal death). Twenty patients required more than 30 days’ hospitalisation, and 15 required three or more …
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Spectrum Of Causes Of Isolated Aortic Regurgitation At A South African Public Sector Tertiary Care Institution
… the valve leaflets were rheumatic heart disease, infective endocarditis, degenerative valve disease and bicuspid aortic valve. Diseases that affect the root and aorta included hypertension, Marfan' syndrome, syphilitic aortitis, Takayasu's arteritis; and pyogenic aortitis. Of the 141 patients in …
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Surgical management of aortic prosthetic valve endocarditis
Background: Infective endocarditis (IE) is still associated with high mortality and morbidity despite advances in diagnostic, medical and surgical management. Aims: I. To report short- and mid-term results after surgical treatment of IE in the current era and to compare the results between native …
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Evaluation of amoxicillin, metronidazole and gentamicin dosage regimens for use in antibiotic prophylaxis in colorectal surgery
… 4 hours, however, in patients at high risk of infective endocarditis,additional doses are required every 2 hours. Following a dose of 500 mgmetronidazole, a re-dosing interval of 8 hours would be acceptable for patients withnormal weight (BMI <25 kg/m2), whereas for patients with a BMI ³25 …
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Functional Characterization of the Streptococcus sanguinis com Regulon
… cavity. S. sanguinis is also a leading cause of infective endocarditis (IE), a potentially lethal infection of the cardiac valves. S. sanguinis possesses genetic competence, the ability to acquire exogenous DNA into its genome. In the well characterized system of S. pneumoniae, genetic competence …
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Technical evaluation of a Real-time polymerase chain reaction (PCR) assay for the detection of Bartonella spp for diagnostic purposes
Infective endocarditis (IE) is a rare disease affecting heart tissues. The laboratory diagnosis of culture-negative endocarditis is complicated, and largely based on the combination of nucleic acid detection methods and serological investigation. There is a paucity of published data on microbes …
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Left ventricular submitral aneurysms
… heart disease in two, tuberculosis in four and infective endocarditis in two. Unknown or congenital disease was postulated in nine patients. Although LVSMA are thought to be congenital, 8 out of 20 patients (40%) had evidence of co-existent inflammatory pathology. The etiology of LVSMA remains …
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Engineering soluble, high affinity T cell receptor domains for detection of staphylococcal and streptococcal exotoxins
… poisoning, sepsis, toxic shock syndrome (TSS), infective endocarditis, and skin conditions like atopic dermatitis. For purposes of neutralizing or detecting SAg, soluble versions of several Vβ domains against various SAgs have been engineered in the Kranz laboratory. Yeast display and directed …
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The household economic impact of Rheumatic Heart Disease (RHD) in South Africa
… such as atrial fibrillation, stroke, infective endocarditis, and heart failure, all of which can result in premature death. In 2015, RHD was estimated to affect 33 million people globally and resulted in at least 320,000 deaths, nearly all of which were in low and middle-income …
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Caracterización clínica, microbiológica y ecocardiográfica de pacientes con Endocarditis infecciosa en la Fundación Cardioinfantil 2002-2012
Introducción: La endocarditis infecciosa es una infección microbiana del endocardio poco estudiada en nuestro país, la cual se asocia con múltiples complicaciones clínicas, y que presenta una mortalidad importante, que no ha disminuido a lo largo del tiempo sin importar los cambios epidemiológicos, …
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The Care of Hospitalized Intravenous Drug Users in 2019
People who inject drugs, particularly opioids, are a growing population, especially in North Philadelphia. This population is at high risk for medical complications that require hospitalization. While hospitalized, this population poses unique challenges to the healthcare system, including high …