Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Infectious colitis"”.
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Colonocyte-Derived Lactate Promotes Enterobacteriaceae Fitness During Non-Infectious Colitis
… by helminth infection, antibiotics, and non-infectious colitis. We specifically probe the contribution of metabolism by members of the Enterobacteriaceae family of bacteria, a group known to commonly outgrow during intestinal inflammation. In the example of non-infectious colitis, we further …
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Characterizing the Role of the E. Coli Cytochrome Oxidase AppBCX During Intestinal Inflammation
During non-infectious colitis, oral antibiotic treatment, and enteric infection, changes in colonocyte metabolism allow for increased oxygen availability in the gut lumen, supporting the growth of facultative anaerobic bacteria primarily from the family Enterobacteriaceae. Additionally, recruitment …
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Dysbiosis-Associated Changes in Host Metabolism Produce Lactate to Support Enterobacterial Expansion During Inflammation
… Enterobacteriaceae family also expand during non-infectious colitis. We investigated whether lactate was also produced during non-infectious colitis and if commensal Enterobacteriaceae could use this nutrient. Butyrate was depleted and lactate was abundant in a murine model of colitis. Metagenomic …
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Immunomodulation by subclinical persistent infection with Helicobacter hepaticus
… rodentium is a well-characterized model of infectious colitis with particular usefulness for modeling human diarrheal disease or inflammatory bowel disease. Infection with Helicobacter hepaticus is subclinical and persistent in C57BL/6 mice, but causes disease in susceptible strains and …
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SNARE-mediated exocytosis of MUC2 from intestinal goblet cells
… is highly susceptible to both chemical and infectious colitis demonstrating the fragility of the intestinal mucosa without proper mucus exocytosis mechanisms.
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Regulation of Host Immune Responses by Toll-Interacting Protein During Citrobacter rodentium Infection
… cause of death in children. Diarrheic enterocolitis can be caused by attaching/effacing (A/E) pathogens like enteropathogenic and enterohemorrhagic Escherichia coli (EPEC and EHEC). Citrobacter rodentium (CR), a murine A/E pathogen, mimics EPEC and EHEC infections, causing goblet cell …
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Neutrophil localization during C. rodentium-induced colitis
… can result in weight loss, diarrhea, hemorrhagic colitis, dehydration and potentially death. To study enteropathogenic colonization further, a murine Citrobacter rodentium (C. rodentium) model is used in this project to understand the activity of neutrophils, often the first cell line of defense, …