Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 754 for “"Infectious Disease"”.
-
Mathematical modeling of infectious disease
The battleground of infectious disease enlists two chief forces: the defending immune system, and the invading pathogen. The immune system consists of a diverse population of leukocytes that recognize foreign material and defend against pathogens. An outstanding feature of this defense is …
-
Computational approaches to understanding infectious disease
Infectious diseases derive from organisms such as viruses, bacteria, fungi and parasites that can be passed from person to person, transmitted via bites from insects or animals, or acquired through ingestion of contaminated food or water or environmental exposure. Infectious diseases cause roughly …
-
Emerging Infectious Disease: Host and Parasite Perspectives
… understanding the consequences of human-mediated disease introduction. The drastic declines of native Hawaiian birds due to avian malaria provided the impetus for examining more closely several aspects of host-parasite interactions in this system. Host-specificity is an important character …
-
Algorithms for Understanding and Fighting Infectious Disease
Infectious disease is a persistent and substantial threat to human health, with consequences that include widespread mortality, suffering, and economic disruption. This thesis presents several algorithmic advances that, when coupled with biotechnologies for data collection and perturbation, are …
-
Modeling transmission heterogeneity for infectious disease outbreaks
The transmissibility of a given infectious disease is often described by its basic reproduction number (Ro) - namely, the average number of secondary infections caused by an index case in a fully susceptible population. Typical approaches to modeling transmission dynamics associated with infectious …
-
News Analytics for Global Infectious Disease Surveillance
Traditional disease surveillance can be augmented with a wide variety of open sources, such as online news media, twitter, blogs, and web search records. Rapidly increasing volumes of these open sources are proving to be extremely valuable resources in helping analyze, detect, and forecast …
-
Human enteroids as a model for infectious disease
… to distal sites in the body or cause acute disease within the GI tract. For many years we lacked a suitable cell culture system for modeling the epithelial celluarlity of the human GI tract, thus our understanding of how the human intestinal epithelium responds to infection has been limited …
-
Insights from serological surveillance in infectious disease epidemiology
Traditional infectious disease surveillance methods rely on testing of symptomatic individuals. However, such methods are often poor indicators of the true burden of infection in a population due to varying rates of subclinical infections, non-specific symptoms, and heterogeneity in health seeking …
-
Multi-state modelling to estimate infectious disease burden
Infectious diseases have plagued humanity for millennia, with outbreaks such as cholera and smallpox claiming countless lives. As was demonstrated by COVID-19, our interconnected world is now more susceptible than ever to the global spread of an infectious disease pandemic. Despite advances in …
-
Human mobility and spatial models for infectious disease
… determinant for the spatial spread of human infectious diseases such as influenza but obtaining human mobility datasets has historically been difficult. This thesis investigates two ways to represent human mobility in spatial metapopulation models for the spread of influenza in the US and UK …
-
Exploring the Multi-scale character of infectious disease dynamics
… study characterised multiscale models of infectious disease dynamics. This was achieved by establishing when it is appropriate to implement particular mathematical methods for different multiscale models. The study of infectious disease systems has been elucidated ever since the discovery …
-
Smartphone-based systems for mobile infectious disease detection and epidemiology
Infectious diseases remain a serious public health challenge worldwide and are the leading cause of death in many developing countries. The rapid detection of pathogens is vital for the control and prevention of the infectious diseases. New tools are needed to enable rapid detection, …
-
Examining the use of infectious disease modelling in outbreak response
Infectious disease modelling has been brought to the forefront of national public health decision making during the Covid-19 pandemic. While the field is highly technically developed, transformation of insights from infectious disease modelling into policy in a clear, timely, and relevant manner is …
-
Modeling social response to the spread of an infectious disease
… important not only to detect outbreaks of infectious disease early, but also to anticipate the social response to the disease. In this thesis, we use social network analysis and data mining methods to model negative social response (NSR), where a society demonstrates strain associated with …
-
Exploring the drivers and consequences of emerging infectious disease of wildlife
Emerging infectious diseases of wildlife have threatened host populations of diverse taxa in recent history, which is largely attributable to anthropogenic global change. In three data chapters, this dissertation examines the drivers of individual- to population-level variation in how host …
-
Quantitation of Anti-Infectious Disease Molecules Utilizing Paper Spray Mass Spectrometry
Suboptimal dosing of anti-microbial agents increases the likelihood of therapeutic failure and resistance. Dosing optimization, while an attractive approach to combat these issues, is difficult to implement due to the different pharmacokinetics of each individual. These limitations highlight the …
-
Spatial Infectious Disease Transmission Models: Variable Screening Methods and Logistic Formulation.
Infectious disease outbreaks have widespread consequences, affecting not only health, economies, and agriculture, but also global trade, social structures, and education (Rohr et al., 2019; Vurro et al., 2010; Anderson, 2002). Advanced mathematical models of infectious diseases, particularly …
-
Population dynamics of infectious disease and pathogen evolution: modelling vaccine escape
This thesis investigates how the risk that an infectious pathogen evolves antigenically (leading to pathogen strains that evade existing immunity) depends on the vaccination coverage of its host population. Deterministic compartmental models are coupled with a parsimonious approach to pathogen …
Page 1 of 38