Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Infection and Immunity"”.
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Study of Infection, Immunity, Vaccine and Therapeutics Using Gnotobiotic Pig Models of Human Enteric Viruses
… (Gn) pigs are a unique animal model for studying infection and immunity, and evaluating vaccine and therapeutics for human enteric pathogens. Here, we demonstrate Gn pigs as effective large animal models for human enteric viruses, through evaluating human enterovirus 71 (EV71) infection and …
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Proteomic Investigation of Interferon Alpha Stimulation and Viral Regulation to Identify Candidate Antiviral Restriction Factors
… proteins that play key roles in inhibiting viral infection. The plasma membrane provides a critical interface between the cell and the virus, meaning that proteins present here are well situated to act as ARFs. An understating of these ARFs and how viruses interact with them, is crucial to our …
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A systematic evaluation of the role of infection, immunity and inflammation in cholesterol gallstone pathogenesis
Cholesterol gallstones are exceptionally common and cost nearly 10 billion U.S. dollars annually. Despite a half-century of basic and clinical research questions still remain about cholesterol gallstone pathogenesis. The purpose of the study presented herein is to analyze the roles of infection, …
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Defining a Role for Inducible Heat Shock Protein 70 (HSP70i) In Mediating Autoimmune Vitiligo
… first suggested to us a link between HSPs and stress-induced vitiligo. Such proteins are marvelously well conserved throughout evolution, which has placed them in the spotlight for helping to understand the intriguing relationship between infection and immunity. Intracellularly, inducible …
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The pivotal role of dendritic cells in feline immunodeficiency virus infection
… first cell types encountered during lentivirus infections. The studies set forth in this dissertation initiated investigations into the interactions of FIV and DC. Accordingly, objectives addressed here were: (1) to develop methods to culture feline DC; (2) to evaluate the susceptibility of …
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Pathogenesis, immunity, and prevention of human norovirus infection in gnotobiotic pigs
… cause of viral epidemic acute gastroenteritis and responsible for the deaths of over 200,000 children each year worldwide. HuNoV research has been hampered by the long absence of a readily reproducible cell culture system and a suitable small animal model, while gnotobiotic (Gn) pigs have been …
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Genomics & Gastroenteritis - A Journey in Applied Epidemiology
… Victorian Government Department of Health (DH), and the Microbiological Diagnostic Unit Public Health Laboratory (MDU PHL) at the Peter Doherty Institute for Infection and Immunity. As part of my field placements, I completed four projects to meet the requirements of the MAE. I was involved in an …
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Genomics & Gastroenteritis - A Journey in Applied Epidemiology
… Victorian Government Department of Health (DH), and the Microbiological Diagnostic Unit Public Health Laboratory (MDU PHL) at the Peter Doherty Institute for Infection and Immunity. As part of my field placements, I completed four projects to meet the requirements of the MAE. I was involved in an …
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A novel cough aerosol sampling device for sputum-scarce individuals with tuberculosis
… worldwide, with 1.6 million deaths. Bacterial infection occurs when aerosol droplets enter the respiratory tract and travel to the lungs, causing pulmonary disease. If untreated, the disease has a 50% mortality rate. TB diagnostics require a sputum sample to conduct tests to confirm the …
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Influence of Enteric Microbiota on Human Rotavirus and Human Norovirus Infection, and Rotavirus Immunity in Gnotobiotic Pigs
Enteric microbiota influences enteric viral infections, and host response to these pathogens and vaccines. Using gnotobiotic (Gn) pigs transplanted with human gut microbiota (HGM), we studied the effects of HGM on the immune response to oral rotavirus vaccination and rotaviral disease. We also used …
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TLR1 I602S: trafficking dynamics and roles in resistance to mycobacterial infection
Innate immunity provides defense mechanisms required for protection against constant exposure to potentially pathogenic microorganisms. Essential to this role is the ability to rapidly recognize the presence of foreign components or organisms indicative of infection. Toll-like receptors (TLR), a …
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Interaction of the porcine reproductive and respiratory syndrome virus with the macrophage-specific lectin sialoadhesin
The porcine reproductive and respiratory syndrome virus (PRRSV) causes the economically most important viral disease in swine industry today. The virus is a major threat to swine health worldwide, since it is both associated with the porcine respiratory disease complex and the cause of severe …