Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Induction therapy"”.
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Improving outcomes for obese children with Acute Lymphoblastic Leukaemia (ALL): a clinical collaboration to understand the influence of obesity on treatment success.
… at diagnosis and after the intense phase of induction therapy to investigate if dysregulated adipokine profiles contribute to weight gain and MRD risk. To achieve this weight status and BMI was recorded and blood plasma was tested using human adipokine arrays at diagnosis and following …
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Using urinary MCP-1 and TWEAK to assess disease activity in a cohort of South African patients with lupus nephritis
… LN patients at baseline, after sixmonths of induction therapy, and at one-year. Results: Throughout the study there was correlation between uMCP-1 and uTWEAK (r=0.52, p< 0.001). Both biomarkers also correlated with standard of care tests and clinical scores. The median [interquartile range] …
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Retrospective comparison of cyclophosphamide and mycophenolate mofetil in lupus nephritis at Groote Schuur Hospital nephrology unit
… with requirement for kidney replacement therapy and death. Efficacy of induction therapies using mycophenolate mofetil (MMF) or intravenous cyclophosphamide (IVCYC) has been reported from studies, but there is limited data in Africans comparing both treatments in patients with …
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Type 1 Interferon: A Negative Regulator Of Myeloid-Derived Suppressor Cells Function In Cancer
… using p38 inhibitor combined with the interferon induction therapy using Poly:IC elicited a robust anti-tumor effect. Thus, negative regulatory mechanisms of MDSC function can be exploited therapeutically.
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Somatic Mutation Detection in Leukemia-Derived Circulating DNA: Utility in Monitoring Clonal Dynamics and Disease Response in Pediatric Acute Lymphoblastic Leukemia
… in response to selective pressure exerted by therapy; relapse founder clones emerge from pre-leukemic clones or minor subclones present at diagnosis. It is hence crucial to develop biomarkers capable of tracking subclones throughout therapy. Current practices for monitoring disease response in …
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Correlation of urinary mcp-1 and tweak with renal histology and early response to therapy in newly biopsied patients with lupus nephritis in cape town, South Africa
… monitoring flares and assessing response to therapy. We assessed the utility of urinary MCP-1 (uMCP-1) and TWEAK (uTWEAK) in predicting renal histological findings, disease flares and treatment response 6 months following initiation of treatment for LN in newly biopsied patients. Methods: We …
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Peripheral inflammatory and regulatory immune changes in HIV positive to HIV positive renal transplant recipients
… received Anti-thymocyte globulin (ATG) induction therapy and maintenance immunosuppression. Despite transplantation across Human Leukocyte Antigen (HLA) mismatches, there were few rejection events in the first year post-transplant (PT). Recipient CD4 counts did not decrease and HIV viral …
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Tratamiento de primera línea en pacientes con diagnóstico reciente de Mieloma Múltiple candidatos a trasplante: Network Metaanálisis
Introducción: El mieloma múltiple es la segunda neoplasia hematológica más frecuente, los pacientes con reciente diagnóstico (NDMM) que son candidatos a trasplante autólogo, requieren una terapia de inducción que logre llevar el paciente a la mejor respuesta, enfermedad libre de progresión y …