Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Induction of angiogenesis"”.
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Differences in the regulation of Thrombospondin-1 expression between epithelial cells and fibroblasts
Induction of angiogenesis is a critical and rate-limiting step in the progression of cancer. It is widely acknowledged that this induction requires the concomitant stimulation of pro-angiogenic and repression of anti-angiogenic proteins. It has been demonstrated that in human epithelial cells …
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The Effects of Smooth Muscle Cells on Engineered Microvasculatures in Fibrin Hydrogels
<p>Capillaries are comprised of two cell types: the endothelial cells (ECs) which line the lumen of the capillary, and the supporting pericytes which are closely apposed to the abluminal surface of the capillary wall (sometimes called mural cells). These pericytes are phenotypic derivations of …
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Stimulation of angiogenesis through collagen gel by applying shear stress and interstitial flow
The induction of angiogenesis has been documented in many diseases such as cancer, arthritis, and diabetes. Angiogenesis can be stimulated by a variety of signals including a mechanical stress applied to the apical side of endothelial cells. To get a better understanding of this mechanical …
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MICRO-CT EVALUATION OF MSC/HUVEC/HSC-MEDIATED ANGIOGENESIS IN LARGE PCL-ßTCP CONSTRUCTS IMPLANTED IN NUDE MICE
… prerequisite for scaffold-guided reconstruction of large voluminous bony defects. However, induction of angiogenesis remains a major challenge for bone-tissue engineering. The present in vivo study evaluates human umbilical cord derived vascular endothelial cells (HUVEC) or hematopoietic stem …
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The role of MMP10 in non-small cell Lung cancer, and pharmacological evaluation of its potential as a target for therapeutic intervention. Investigation of the role of MMP10 in the tumour microenvironment of non-small cell lung cancer using gene, protein and mass spectrometry approaches to determine MMP10’s potential in drug development strategies
… Cell Lung Cancer (NSCLC), which accounts for 80% of all lung cancer cases, is associated with resistance to chemotherapy and poor prognosis. Exploitation of NSCLC-upregulated pathways that can either be targeted by novel therapeutics or used to improve the tumour-delivery of current …
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An Optogenetic Toolbox for the Interrogation of Dynamic Events During Angiogenesis
Characterization of highly dynamic processes such as the induction of angiogenesis has historically been limited by a lack of tools with sufficient spatiotemporal control. To address the spatiotemporal requirements for VEGF-induced tip cell development, we designed an optogenetic VEGFR2 utilizing …
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Pharmacokinetics of local growth factor delivery in myocardial tissue
An emerging approach for the treatment of ischemic heart disease is the induction of angiogenesis by means of the locally delivering growth factors to the myocardium. When deposited within heart tissue the compounds elicit a vascular response that is hoped to perfuse ischemic myocardium. There is, …
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Lattice-gas cellular automata for the analysis of cancer invasion
… a step-wise manner during carcinogenesis. Some of these traits are autonomous growth, induction of angiogenesis, invasion and metastasis. In this thesis, the focus is on one of the latest stages of tumor progression, tumor invasion. Tumor invasion emerges from the combined effect of tumor …
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Συσχέτιση της βιοσύνθεσης των βασικών μεμβρανών με την αγγειογένεση
Angiogenesis is an important determinant for the diagnosis or the therapeutic intervention in the so called "angiogenic diseases" e.g. diabetic retinopathy, chronic inflammation neoplasma. A biochemical method is suggested here for the evaluation of angiogenesis which is based on the fact that …