Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"Inducible nitric oxide synthase"”.
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Cardiovascular function in animal models of metabolic syndrome and type 2 diabetes : the role of inducible nitric oxide synthase (iNOS)
Activation of inducible nitric oxide synthase (iNOS) and oxidative stress have been shown to be associated with compromised cardiovascular function in streptozotocin (STZ)-induced type 1 diabetes. The aim of the project is to investigate cardiovascular abnormalities in a rat model of type 2 …
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Effect of blueberry polyphenols on osteoclast
… 1 (NFATc1), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) were determined. Blueberry polyphenols were shown to be effective by decreasing iNOS, COX-2 and TRAP levels. This study indicates that blueberry polyphenols decrease osteoclast activity through multiple …
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The mechanism for paraquat toxicity involves oxidative stress and inflammation : a model for Parkinson's disease
… cells respond to cytokines by induction of inducible nitric oxide synthase which produces nitric oxide (NO). Our results show that paraquat inhibited cytokine-induced NO production but only moderately enhanced ROS production in microglial cells. We wanted to determine the role of NADPH …
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Macromolecular Complexes of Cystic Fibrosis Transmembrane Conductance Regulator Alter Fluid Transport in inflammatory Bowel Disorders
… physical and functional coupling of CFTR with nitric oxide (NO) producing enzyme-inducible nitric oxide synthase (iNOS) at the apical plasma membrane in inflammatory bowel disease (IBD). The complex formation requires the scaffolding protein Na+ /H+ exchanger regulatory factor 2 (NHERF2). We …
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IFN-γ Induced Nitric Oxide Leads to the Inhibition of TH17 Differentiation via iNOS
… we explored how IFN-γ, through its regulation of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production, influences Th1 and Th17 responses in the Experimental Autoimmune Encephalomyelitis (EAE) model and in vitro T cell assays. Our results demonstrate that the absence of IFN-γ …
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Biomarkers of oxidative stress and inflammation in biological samples collected from recurrent airway obstruction (RAO)-affected horses and their controls
… of interleukin 4 (IL4), gamma interferon (INFγ), inducible nitric oxide synthase (iNOS), extracellular glutathione peroxidase (GPx-3), and cytosolic superoxide dismutase (SOD-1) were not significantly different or were at the limits of detection. Conductivity was measured and assessed as a …
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Anti-inflammatory and chondroprotective role of tart cherry polyphenols in SW1353 human chondrocytes
… levels occurred with concomitant decreases in inducible nitric oxide synthase (iNOS) intracellular protein expression at the two highest TCP doses. Reductions in cartilage degradation were observed in the 2.5, 5, and 10 µg/mL TCP doses, as indicated by decreases in glycoprotein-39 (YKL-40) …
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Brain Inflammation Regulated by PINK1
… 6 to 24h were higher in KO slices. Expression of inducible nitric oxide synthase (iNOS) was not detected in either KO or WT slices. Furthermore, nitrite production was continuously increased for up to 72 h in both WT and KO slices. There was no difference in the production levels, which suggests …
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Citrulline metabolism in cultured fibroblasts : citrullinemia analysis and nitric oxide production
… In the second section, the presence of the nitric oxide pathway in fibroblasts was investigated. Inducible nitric oxide synthase activity was assayed by measuring the production of ¹⁴C-citrulline from ¹⁴C-arginine after cytokine stimulation. By using the citrullinemic cell line (ASS …
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Anti-Inflammatory Mechanism By Oxysterols In Cultured Rat Brain Astrocytes
… astrocytes, both oxysterols suppressed inducible nitric oxide synthase expression and nitric oxide release as well as upstream signaling molecules including interferon-, phosphorylated signal transducer and activator of transcription 1/3, and interferon regulatory factor-1. And …
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The effects of dietary β-glucan supplementation on performance and immune response of broiler chicks during an Eimeria challenge
… (IL)-8, IL-18, interferon (IFN)-γ and inducible nitric oxide synthase (iNOS) in the small intestine. A subsequent study was conducted to investigate the effects of dietary β-glucan on broiler chick (1440 birds) performance and immune response during a mixed Eimeria infection (day 8 of …
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Study on the Neuroprotective Effects of Ethyl pyurvate in MPTP-induced Mouse PD Models
… astroglial MPO expression, NADPH oxidase- and/or inducible nitric oxide synthase-derived ROS/RNS production by activated microglia. In parallel, treatment of EP significantly increased GDNF and CNTF in the MPTP-treated SN. Also, EP was found to protect DA neurons from 1-methyl-4-phenyl-pyridinium …
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Engineered E. Coli That Detect and Respond to Gut Inflammation Through Nitric Oxide Sensing
… of a permanent DNA switch in response to nitric oxide produced by inducible nitric oxide synthase. The detection of nitric oxide initiates the expression of a DNA recombinase, causing the permanent genetic rearrangement of a short DNA segment containing a gene promoter, allowing for the …
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Transient receptor potential vanilloid 1 exhibits neuroprotective effects in LPS-induced dopaminergic neuronal death in the suabstantia nigra in vivo.
… production of proinflammatory mediators such as inducible nitric oxide synthase (iNOS) and ROS while CAP increases Arginase 1 and CD206, M2 macrophage markers. In addition, CAP protected nigral DA neurons from LPS-induced neurotoxicity. This neuroprotective effect was reversed by capsazepine, a …
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Einfluss der löslichen Guanylylzyklase auf die Expression der cGMP-Exporter MRP4 und 5 in humanen Melanomzellen unter Hypergravitationsbedingungen
… expression of MRP4/5, endothelial and inducible nitric oxide synthase (e/iNOS) and particulate GC (GC-A/B) in the non-metastatic 1F6 melanoma cell line was studied by silencing the mRNA-expression of the sGCb1 subunit through siRNA-transfection. The data show an increased expression of …
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Zytokinexpression in der ischämischen Penumbra nach transientem Verschluß der A. cerebri media in der Ratte
… neurons. At the same time an expression of the inducible nitric oxide synthase took place which led to the production of the gas NO und at least to the formation of the heavily zytotoxic agent peroxinitrite. The expression of i-NOS remained raised up to day 14 after ischemia, too. With the help …
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Applications for human neural stem cell-derived motor neurons in amyotrophic lateral sclerosis: Cell replacement therapy and disease modeling
… mutant SOD1(G93A) microglia. Using inhibitors of inducible nitric oxide synthase and NADPH oxidase as well as scavengers for reactive oxygen and nitrogen species (ROS/RNS), we showed that microglia-generated nitric oxide, superoxide and peroxynitrite, at least, partially contributed to motor …
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A Novel Mechanism of Skin Tumor Promotion Involving Interferon-Gamma (Ifnγ)/Signal Transducer and Activator of Transcription-1 (Stat1) Signaling In Epidermis
… maximal induction of both cyclooxygenase-2 and inducible nitric oxide synthase in epidermis following treatment with CHRY was also dependent on the presence of functional Stat1. Following CHRY treatment, Stat1<sup>-/-</sup> mice exhibited reduced macrophage infiltration and reduced production of …
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