Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"Inducible Nitric Oxide synthase(iNOS)"”.
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Cardiovascular function in animal models of metabolic syndrome and type 2 diabetes : the role of inducible nitric oxide synthase (iNOS)
Activation of inducible nitric oxide synthase (iNOS) and oxidative stress have been shown to be associated with compromised cardiovascular function in streptozotocin (STZ)-induced type 1 diabetes. The aim of the project is to investigate cardiovascular abnormalities in a rat model of type 2 …
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Effect of blueberry polyphenols on osteoclast
… 1 (NFATc1), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) were determined. Blueberry polyphenols were shown to be effective by decreasing iNOS, COX-2 and TRAP levels. This study indicates that blueberry polyphenols decrease osteoclast activity through multiple …
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Macromolecular Complexes of Cystic Fibrosis Transmembrane Conductance Regulator Alter Fluid Transport in inflammatory Bowel Disorders
… physical and functional coupling of CFTR with nitric oxide (NO) producing enzyme-inducible nitric oxide synthase (iNOS) at the apical plasma membrane in inflammatory bowel disease (IBD). The complex formation requires the scaffolding protein Na+ /H+ exchanger regulatory factor 2 (NHERF2). We …
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IFN-γ Induced Nitric Oxide Leads to the Inhibition of TH17 Differentiation via iNOS
… we explored how IFN-γ, through its regulation of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production, influences Th1 and Th17 responses in the Experimental Autoimmune Encephalomyelitis (EAE) model and in vitro T cell assays. Our results demonstrate that the absence of IFN-γ …
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Biomarkers of oxidative stress and inflammation in biological samples collected from recurrent airway obstruction (RAO)-affected horses and their controls
… of interleukin 4 (IL4), gamma interferon (INFγ), inducible nitric oxide synthase (iNOS), extracellular glutathione peroxidase (GPx-3), and cytosolic superoxide dismutase (SOD-1) were not significantly different or were at the limits of detection. Conductivity was measured and assessed as a …
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Anti-inflammatory and chondroprotective role of tart cherry polyphenols in SW1353 human chondrocytes
… levels occurred with concomitant decreases in inducible nitric oxide synthase (iNOS) intracellular protein expression at the two highest TCP doses. Reductions in cartilage degradation were observed in the 2.5, 5, and 10 µg/mL TCP doses, as indicated by decreases in glycoprotein-39 (YKL-40) …
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Brain Inflammation Regulated by PINK1
… 6 to 24h were higher in KO slices. Expression of inducible nitric oxide synthase (iNOS) was not detected in either KO or WT slices. Furthermore, nitrite production was continuously increased for up to 72 h in both WT and KO slices. There was no difference in the production levels, which suggests …
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The effects of dietary β-glucan supplementation on performance and immune response of broiler chicks during an Eimeria challenge
… (IL)-8, IL-18, interferon (IFN)-γ and inducible nitric oxide synthase (iNOS) in the small intestine. A subsequent study was conducted to investigate the effects of dietary β-glucan on broiler chick (1440 birds) performance and immune response during a mixed Eimeria infection (day 8 of …
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Transient receptor potential vanilloid 1 exhibits neuroprotective effects in LPS-induced dopaminergic neuronal death in the suabstantia nigra in vivo.
… production of proinflammatory mediators such as inducible nitric oxide synthase (iNOS) and ROS while CAP increases Arginase 1 and CD206, M2 macrophage markers. In addition, CAP protected nigral DA neurons from LPS-induced neurotoxicity. This neuroprotective effect was reversed by capsazepine, a …
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HDAC6 Deletion Decreases Pristane-Induced Inflammation and Lupus
… which caused the synthesis of inducible nitric oxide synthase (iNOS) in cells activated by LPS and IFN-γ. Long-term pristane treatment induced proteinuria in female mice although there were no significant differences between WT and HDAC6-/- animals. HDAC6 deletion significantly …
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The impact of glucotoxicity on pancreatic β-cell function
… data showed abnormally increased expression of inducible nitric oxide synthase (iNOS) protein in the islets from diabetic donors as well as in the islets exposed to chronic hyperglycemia. cAMP analogue or PDE inhibitors counteract these abnormalities and restore β-cell function at least in part, …
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Transport and utilization of arginine and arginine-containing peptides by rat alveolar macrophages
… utilized these peptides as direct substrates for nitric oxide (NO) production.;Method. A HPLC assay was developed for quantitative measurement of Arg and ACPs in rat plasma and bronchoalveolar lavage (BAL) fluid. The uptake of small peptides by rat AM was evaluated using fluorescein isothiocynate …
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Novel Strategies in Cardioprotection against Ischemia/Reperfusion Injury
… mediators including adenosine, bradykinin or nitric oxide (NO), that may trigger a signaling cascade leading to protection against I/R injury. Our results show that sildenafil, at a clinically relevant dose, induced powerful acute and delayed cardioprotection against I/R injury in an in vivo …
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Biological and Chemical Investigation of Panamanian Plants for Potential Utility against Metabolic Syndrome
… receptors (LXRs), nuclear factor-κB (NF-κB), and inducible nitric oxide synthase (iNOS) which are key regulators of various processes leading to metabolic disorder and inflammation. As a part of inflammatory pathway, activation of NF-κB leads to insulin resistance and by blocking this pathway, …
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Identification and Analysis of Omentum Derived Suppressor Cells in Regards to Th17 Inhibition
… relied on IFNɣ-mediated upregulation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), leading to generation of nitric oxide (NO) and prostaglandin E2 (PGE2). These mediators inhibited differentiated Th17 cells in vitro, resulting in cell loss, and blockade of …
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The Novel Long Non-Coding RNA Nostrill Regulates Intestinal Epithelial Defense Against Cryptosporidium parvum and Modulates Microglial-Mediated Neurotoxicity
… of Nostrill is NF-κB-dependent and promotes inducible nitric oxide synthase (iNOS) expression and downstream nitric oxide (NO) production. In vitro studies demonstrated that knockdown of Nostrill in microglia reduced LPS-stimulated microglial neurotoxicity. Investigation of the underlying …
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The bioactive role of omega-3 endocannabinoid epoxide regioisomers
… (EDP-EAs) that are known as omega-3 eCB epoxides. Previously, 17,18-EEQ-EA and 19,20-EDP-EA have shown to have anti-neuroinflammatory, vasodilatory, anti-angiogenic properties, activate cannabinoid receptors and regulate platelet aggregation in vitro. Although these metabolites have …
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Dendritic Cells in Normal and Inflamed Human Skin
… marker. Some myeloid cells expressed TNF and inducible nitric oxide synthase (iNOS). Treatment of psoriasis patients with the TNF neutralizing antibody etanercept not only inhibited dendritic cells as expected, but also had inhibitory effects on a newly appreciated type of T cell – Th17 cells. …
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Sulforaphane as a potential nutritional intervention to reduce neuroinflammation associated with aging and sickness behavior
… molecules such as interleukin (IL)-1β, IL-6, and inducible nitric oxide synthase (iNOS). Aging is associated with chronic neuroinflammation that is represented by behavioral and cognitive impairment, and increased risk of neurodegenerative disease. Aging-associated inflammation is thought to shift …
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EXPLOITATION OF ANTIOXIDANT BIOACTIVE COMPOUNDS FROM AGRO-INDUSTRIAL BY-PRODUCTS
… (plant steam-distillation); − Caper (Capparis spinosa L.) brine residue from salty flower buds’ production. Once the agro-industrial by-products were selected, the study focused on identifying the best extraction techniques according to the principles of green chemistry and sustainability. In …
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