Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Induced neurons"”.
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Chemogenetics, Induced Neurons and Pluripotent Stem Cells: Towards Advanced Gene and Cell Therapies Targeting Epilepsy
… by introducing new populations of GABA-releasing neurons, might prove therapeutic for epilepsy, by counteracting seizures and even modifying the disease. Gene therapy offers localized, cell-type specific alteration of neuronal excitability, but on-demand seizure suppression can only be achieved by …
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Investigating Microtubules Inside Cells with Cryo-Electron Tomography
… motor-driven transport. Axons and dendrites of neurons are filled with longitudinal arrays of microtubules. They serve as tracks for long-range cargo transport driven by the microtubule-based motors kinesin and dynein. This transport can be visualized in light microscopy but the structure of …
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Clinical aspects and in vitro modelling of GBA1 variant-associated Parkinson's disease
… novel disease model using directly reprogrammed induced neurons (iNs) in which to test putative disease-modifying treatments. Firstly, long-term data from two incident PD clinical cohorts is presented, which constitutes the longest follow-up study of GBA1-PD to date. Consistent with previous …
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Master regulators of neuronal maturation in NGN2 reprogrammed iPSC-derived iNeurons
… that Neurogenin 2 (NGN2) overexpression in induced pluripotent stem cells results in their rapid conversion into excitatory induced neurons (iNeurons) that are morphologically complex and electrophysiologically active after 2 weeks in culture. In addition, the inducible control of NGN2 …
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Cellular Phenotypes Associated with NRXN1 Mutations in Autism; an iPSC Study
… model is needed. In this thesis I have used induced neurons derived from induced pluripotent stem cells (iPSC) using the OPTi-OX system to study the impact of NRXN1 mutations on excitatory glutamatergic neurons. I specifically study the molecular, morphological and functional changes caused …
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Integrative genomic analysis of Neurogenin2 reprogramming of human iPSCs
… stem cells (PSCs) into functional excitatory neurons. My lab has previously demonstrated that gene targeting the components of a Tet-On system overexpressing NGN2 into two separate safe harbour sites overcome gene silencing and results in optimised transgene expression in hiPSCs (Opti-Ox), and …