Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Indolocarbazole"”.
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Design, synthesis and development of novel indolocarbazole derivatives as potential anti-cancer agents
This thesis describes work carried out on the design of new routes to a range of bisindolylmaleimide and indolo[2,3-a]carbazole analogs, and investigation of their potential as successful anti-cancer agents. Following initial investigation of classical routes to indolo[2,3-a]pyrrolo[3,4-c]carbazole …
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Studies into the Biosynthesis and Chemical Synthesis of Indolocarbazoles and Related Heterocyclic Compounds. Metalation of Indole-6-Carboxamide.
… plays a pivotal role in the biosynthesis of the indolocarbazole alkaloid rebeccamycin. A homologous enzyme, StaC, exists in the biosynthetic pathway for staurosporine, a related indolocarbazole. Structural differences between the RebC and StaC active sites were hypothesized to play a pivotal role …
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Synthesis and evaluation of novel azaindolocarbazole derivatives as cancer chemotherapeutics
… propitious 7-azaindolyl derivatives of the indolocarbazole (ICZ) and bisindolylmaleimide (BIM) families, with subsequent evaluation for use as cancer chemotherapeutic agents. A robust synthetic strategy was devised to allow the introduction of a 7-azaindolyl moiety into our molecular …
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Metagenomics-Based Tryptophan Dimer Natural Product Discovery and Development Pipeline
… TD families (i.e. indolotryptoline, carboxy-indolocarbazole, and bisindolylmaleimide), consisting of 15 novel natural products (e.g. BE 54017s, borregomycins, erdasporines) with therapeutically relevant bioactivities (e.g. antitumor, antibacterial). Linking biologically active natural …
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Indoles y pirroles alquinil funcionalizados: síntesis y transformaciones catalizadas por complejos de oro(III)
… un procedimiento que permite la síntesis de dos indolocarbazoles. Para finalizar, en el último apartado de esta Tesis Doctoral se ha trabajado en la puesta a punto de una ruta sintética para acceder a indoles a partir de bis(2-bromoalil)aminas. Los resultados obtenidos ponen de manifiesto el …