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Showing 1 to 8 of 8 for “"Indolizidines"”.
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[4+2] cycloadditions of iminoacetonitriles : a general strategy for the synthesis of quinolizidines, indolizidines, and piperidines
… cycloadditions leading to quinolizidines, indolizidines, and piperidines. The resultant a-amino nitrile cycloadducts are versatile synthetic intermediates which can be further elaborated by stereoselective alkylation, reduction, reductive cyclization, and Bruylants reactions. The first part …
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[4 + 2] cycloadditions of iminoacetonitriles : synthesis of highly substituted tetrahydropyridines and indolizidine alkaloids
… reactions affording tetrahydropyridines and indolizidines. The [alpha]-amino nitrile cycloadducts are versatile synthetic intermediates that participate in a variety of stereoselective transformations to further elaborate the six-membered ring. This thesis describes the scope of the …
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Enantioselective [4 + 2] cycloadditions of iminoacetonitriles : application to the total synthesis of (-)-quinolizidine 2071
… cycloadditions affording quinolizidines and indolizidines. The resulting a-amino nitrile cycloadducts are versatile intermediates that can be further elaborated in a stereoselective manner. This thesis describes the development of intramolecular, enantioselective aza Diels- Alder …
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Synthesis of nitrogen heterocycles via the intramolecular [4+2] cycloaddition of iminoacetonitriles
… affording substituted quinolizidines and indolizidines. The cycloadducts are formed with a high preference for an exo-orientated cyano group due to the a-amino nitrile anomeric effect. The substrates for these [4+2] cycloadditions are prepared from readily available alcohols via a …
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Stereoselective synthesis : studies involving dipole-stabilized carbanions alpha to nitrogen
Organolithiums are key reagents and intermediates in organic synthesis. An exciting and growing field is the use of organolithiums in enantioselective synthesis. The often complex nature of these compounds makes their implementation towards the synthesis of natural products or pharmaceutical …