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Showing 1 to 20 of 84 for “"Indoles"”.
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Novel synthesis of 3,4-fused indoles
… goal of this project was to synthesize 3,4-fused indoles having a variety of ring sizes and a variety of functional groups. This has been accomplished by the development of a novel palladium-catalyzed route to 3,4-fused indoles. The key steps are two palladium-catalyzed reactions, an …
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The Conversion of Quinone-Imides to Indoles
Made available in DSpace on 2014-12-05T19:36:13Z (GMT). No. of bitstreams: 1 0013556.pdf: 7327736 bytes, checksum: c4ba3557dc85ce9b981beecc88e9818f (MD5) Previous issue date: 1955
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Synthesis of indoles via zirconocene-stabilized benzyne complexes
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1994.
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A base modulated synthesis of indoles and quinolines, an expedient synthesis of salviadione, and chemoselective couplings en route to indoles and pyrroloindoles
… useful method for the construction of indoles and indole-based heterocycles. Soderberg's elaboration of this methodology has been utilized in the synthesis of indoles and quinolines from a common precursor. The same protocol has also been employed in the synthesis of the indole alkaloid …
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Effect of Food Restriction on Serum and Pineal Indoles
<p>Food restriction has profound effects on various endocrine axes and on amine metabolism. In the present study, the effect of reduced food availability on pineal and serum indole was determined in adult male Wistar rats. Under a lighting regimen of 14 h light and 10 h dark, 3 weeks of 50% food …
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Synthesis of indoles via a tandem benzannulation-cyclization strategy
… via several alternate procedures leading to indoles that are highly substituted on the six-membered ring. The cyclization approaches investigated as the second step in this tandem strategy included aromatic substitution, palladium-catalyzed oxidative amination, and nucleophilic cyclization. …
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Novel approaches to functionalized indoles and polysubstituted aromatic compounds
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1997.
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Applying Trichloroacetimidates to the Synthesis of Benzylic Trichloroacetamides & Functionalized Indoles
… for the Friedel-Crafts alkylation reaction with indoles under Lewis acid catalysis. These reactions proceeded well even with electron-deficient benzyl structures. C3-Monobenzylated indoles were produced in excellent yields with high regioselectivity, an important feature since a common challenge …
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Novel titanium carbenoid reagents: diversity orientated synthesis of indoles and spirocycles
… of a 96-member library of 2,5-disubstituted indoles involving traceless cleavage from resin is presented. A boronate-bearing titanium alkylidene was prepared and used to convert 8 resin-bound esters into immobilised enol ethers. Cleavage from resin in mild acid with concomitant cyclisation …
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Effect of High Pressure on the Luminescence of Indoles and Metalloporphyrins
… of pressure on the luminescence properties of indoles and metalloporphyrins were investigated. The indole and indole derivatives were studied in liquid solvents up to 10 kilobars. The metalloporphyrins were studied in both fluid and plastic solvents. Radiative and non-radiative rates have been …
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TANDEM BENZANNULATION-CYCLIZATION STRATEGIES FOR THE SYNTHESIS OF HIGHLY SUBSTITUTED INDOLES
… for the synthesis of highly substituted indoles. The benzannulation strategies involved the reaction of vinylketenes (or aryl ketenes) with ynamides or with ynehydrazides to afford highly substituted phenols via a pericyclic cascade mechanism. The vinylketenes were generated via the Wolff …
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Application of Iridium-Catalysed C–H Borylation to the Functionalisation of Indoles
… of the iridium-catalysed C–H borylation of indoles. Research commenced with the development of a general procedure for the conversion of indoles 242 to 7-hydroxyindoles 245 and indolequinones 243. This was achieved by a three-step procedure – an initial C7–H borylation was followed by …
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I. Persistent radicals for dynamic nuclear polarization : II. Synthesis of substituted indoles
… bound hetero-biradicals are reported. Part II: Indoles are important heterocycles because of their presence as common structural motifs in natural products and pharmaceutical candidates. Second generation Danheiser benzannulation-tandem cyclization approach was developed and applied toward the …
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Development of poly(ADP-ribose) glycohydrolase inhibitors and tetracyclic indoles as anticancer compounds
… of a class of potent anticancer tetracyclic indoles through a phenotypic screen. PARG plays a crucial role in DNA damage repair, and lack of PARG activity after DNA damage prevents repair and causes a build-up of toxic PAR chains. As such, PARG inhibitors have been pursued for decades as …
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Synthesis of indoles via palladium-catalyzed annulation of aryl chlorides and internal alkynes
… preparation of 2,3-disubstituted indoles from commercially available and relatively inexpensive reagents, o-chloroacetanilide and internal alkynes, is reported. The system is efficient in delivering 2,3-disubstituted indoles in good to excellent yield with a high level of …
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Some synthetic applications of 3,4-disubstituted indoles generated via zirconocene-stabilized benzyne complexes
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1997.
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The synthesis of 4-substituted indoles and their elaboration to the ergot alkaloids
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1981.
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Indoles y pirroles alquinil funcionalizados: síntesis y transformaciones catalizadas por complejos de oro(III)
… Doctoral. En el primero de ellos, se parte de indoles y arilglioxales para sintetizar, con ayuda del ácido para-toluensulfónico, bis(indolil)cetonas con rendimientos excepcionalmente elevados. En el segundo capítulo se ha estudiado las diferentes rutas que permiten la formación de carbazoles a …
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