Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 34 for “"Indoleamine"”.
-
Structure guided discovery of inhibitors of indoleamine 2,3-dioxygenase (IDO1)
The enzyme indoleamine 2,3‐dioxygenase‐1 (IDO1) plays a critical role in the regulation of the immune system. IDO1 expression is commonly upregulated in cancer, resulting in a suppressed immune system in patients. Clinical observations that patients with high IDO1‐expressing tumours have a poor …
-
Design and Synthesis of Hydroxylamine Derivatives as Indoleamine - 2,3 - Dioxygenase Inhibitors
<p>Current research describing therole of indoleamine 2,3-dioxygenase (IDO) and its mechanism of action suggests that the inhibition of IDO with small molecule inhibitors, especially in conjunction with chemotherapy, can provide an effective and novel cancer treatment strategy. This inspired our …
-
Neuroinflammation and comorbid depression: a role for interleukin-1 beta converting enzyme and indoleamine 2,3-dioxygenase
… like behavior. The tryptophan degrading enzyme indoleamine 2,3-dioxygenase 1 (IDO1) has also been implicated in neurodegenerative disease and depression. IDO1 activity increases kynurenine concentrations in circulation and brain tissue following LPS administration. Further, IDO1 has been shown …
-
Investigating the Role of Indoleamine 2,3-Dioxygenase 1 and Transforming Growth Factor Beta 1 in Rebound Immune Suppression Following Chemotherapy in Osteosarcoma
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-09-01 without embargo terms
-
Role of serotonin in the regulation of aldosterone secretion from the rat adrenal gland
… et al., first described the effect of the indoleamine serotonin on aldosterone secretion from the adrenal gland. To date numerous studies have reported this steroidogenic effect, describing the second messenger system utilised and in some species the receptor type involved. However the full …
-
Stress and inflammation regulate the kynurenine pathway dioxygenases in a glia‐ and tissue‐specific manner
… and cytokine-inducible enzymes tryptophan and indoleamine 2,3-dioxygenases (DOs: Tdo2, Ido1 and Ido2). The DOs are rate-limiting for tryptophan metabolism by the Kynurenine Pathway. While accumulating evidence supports an interconnection between symptoms of depression and increased Kynurenine …
-
Expression and regulation of the rate-limiting enzymes of the kynurenine pathway in the mouse brain
… the expression of rate-limiting enzymes (indoleamine/tryptophan-2,3-dioxygenase: DOs) that metabolize the essential amino acid tryptophan to kynurenine, 2) detailing a novel interaction between galectins and interferon-gamma to accentuate DO expression within the brain, and finally 3) …
-
The identification and characterization of novel persistence genes in chlamydia trachomatis
… IFN-γ stimulates expression of the host enzyme indoleamine 2,3-dioxygenase. This enzyme converts free intracellular tryptophan to N-formylkynurenine. Tryptophan starvation induces C. trachomatis to enter a viable-but-nonculturable state termed persistence, which has been proposed to play a key …
-
Assessing the immune phenotype of cardiac syndrome x: a prospective study of biomarkers
… We have also demonstrated that the enzyme Indoleamine-2,3- dioxygenase is upregulated in active disease thus providing a possible explanation for the increased burden of psychological disease encountered in CSX. Analysis of the microRNA transcriptome showed that miR-143 is significantly …
-
Characterization and Immunomodulatory Function of Human Mesencymal Stem Cells
… 관여한다는 사실을 알 수 있었다. 중간엽줄기세포에서 IFN-γ에 의해 발현되는 IDO(indoleamine 2,3-dioxygenase)는 T 세포 증식에 필수적인 tryptophan을 분해하여 면역 억제를 유도한다. 면역세포 증식 실험시 anti-IFN-γ를 처리하거나, tryptophan을 첨가하여 면역세포의 증식이 회복되는 결과를 통해서 중간엽줄기세포의 T 세포 증식억제에 IFN-γ와 IDO가 관여한다는 사실을 증명하였다. 또한 중간엽줄기세포에 IFN-γ를 처리하였을 때 세포내 신호전달물질을 확인한 결과 STAT1과 …
-
The involvement of the kynurenine pathway in the pathogenesis of multiple sclerosis
… the involvement of the KP in neuroinflammation [Indoleamine 2,3-dioxygenase (IDO-1) expression and its immune regulatory role] and neurodegeneration (balance between neuroprotective and neurotoxic KP metabolites). The main findings of this project are: (1) the KP metabolism is altered in MS …
-
Mechanism of Chimeric Vaccine Mediated Immune Suppression of Human Dendritic Cells
… up-regulation of the tryptophan catabolic enzyme indoleamine 2, 3-dioxygenase (IDO1) shown to be directly linked to CTB-INS-induced DC activation and maturation. Treatment of vaccinated DCs with the pharmacological NF-κB inhibitors ACHP or DHMEQ inhibited IDO1 biosynthesis, suggesting a role for …
-
Investigating the role of IL-4Rα mediated signalling on Foxp3⁺ T regulatory cells during cutaneous leishmaniasis
… analysis revealed that a L. major-induced Indoleamine 2,3 dioxygenase (IDO)-mechanism could allow for increased Leishmania replication. Collectively, these data suggest a protective role for IL-4Rα signalling on Treg cells in suppressing a detrimental Type 2 during cutaneous leishmaniasis.
-
Psychoneuroimmunology of Interleukin-10
… such as IFN-¦Ã and IL-10 are able to regulate indoleamine 2, 3-dioxygenase (IDO) expression in cells of hypothalamic and pituitary origin. The capability of IL-10 to suppress IFN-¦Ã induced IDO expression implies that IL-10 has a putative neuroprotective role in the HPA axis. These novel data …
-
Herpes Simplex Virus Glycoprotein D/Host Cell Surface Interaction Stimulates <em>Chlamydia trachomatis</em> Persistence via a Novel Pathway.
… activation of inducible nitric oxide synthase or indoleamine 2, 3-dioxygenase; iii) inhibition of vesicular trafficking or sphingomyelin transport to the inclusion or; iv) amino acid, iron or glucose deprivation. These data demonstrate that co-infection-induced persistence is mediated by a …
-
The Addition of Melatonin to 17beta-Estradiol and Progesterone Modulated Markers Relevant to Mammary Tumor Development and Modulated Steroid Receptors Relevant to Uterine Protection in a Mouse Model of Breast Cancer
… cancer-related genes encoding amphiregulin and indoleamine 2, 3-dioxygenase. In the uterus, there were no differences detected in wet weight, luminal epithelial height, and proliferation. Also, there was no effect on serum E2 or P4 levels; however, EPMRT increased the time in estrus. Moreover, …
-
Doxorubicin and T Helper Lymphocytes: Unexpected Allies Against Cancer
… and down-regulation of arginase-1 and indoleamine 2,3-dioxygenase (IDO) expression. Of therapeutic relevance, the frequency of effector lymphocytes (CD4⁺ and CD8⁺ T cells) or natural killer cells (NK) to suppressive MDSC ratios was significantly increased following doxorubicin treatment …
-
A microparticle engineering approach to enhance the potency of mesenchymal stem cells
… potency of MSCs by up-regulating expression of indoleamine-2,3- dioxygenase (IDO) is reported. Loading MSCs with particles containing the glucocorticoid steroid, budesonide, doubled their potency in suppressing activated peripheral blood mononuclear cell co-cultures in an IDO dependent manner. …
-
Combination of Oncolytic Adenoviruses, T-Cell Activation, and Blockade of Ido Metabolic Circuitry For The Treatment of Glioma
… within the glioma microenvironment. For example, indoleamine-2,3-dioxygenase (IDO) is upregulated in glioblastoma, correlates with poor prognoses, and is a main source of immunosuppression. IDO is an IFN inducible enzyme that catabolizes tryptophan resulting in diminished proliferation or …
Page 1 of 2