Global ETD Search
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Showing 1 to 5 of 5 for “"Indole nucleus"”.
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Novel Polycyclic Benzannulated Indole Scaffolds via Indole Aryne Cycloaddition, Pd (0)-Catalyzed Cross-coupling and ROM/RCM methodologies: Their Applications to Library Development and Drug Discovery
… compounds with diverse biological activity. The indole nucleus for instance, is an important element of many natural and synthetic molecules with significant biological activity. Drug discovery and development processes highly value the utility of the ability to synthesize a diverse library based …
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Indole Arynes in organic synthesis : discovery and applications for the total synthesis of complex natural products
… 50 years, arynes derived from the ubiquitous indole nucleus were virtually unknown before our work. The absence of these heteroarynes from the literature was surprising, given the potential utility of these reactive intermediates for an attractive entry into the indole alkaloid class of …
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Recent Advances in Indole Aryne Cycloaddition Chemistry. Part I: Total Synthesis of (±)-cis-Trikentrin B. Part II: Investigation into the Regioselectivity of 6,7-Indole Aryne Cycloadditions. Part III: Synthesis and Reactions of Novel Tribromoindoles
… in the Buszek laboratories in 2007, the indole arynes and their cycloaddition chemistry has demonstrated its significance in achieving the total synthesis of biologically active indole alkaloid natural products such as the trikentrins and herbindoles in a facile manner. The application of …
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Determining the in vitro anti-cancer effects of various novel indoles and an anti-microbial peptide towards a potential treatment of glioma.
Substituted indoles (2-arylindoles) and related structures are known to exhibit potent anti-cancer activity against human breast cancer cell lines, and a range of other therapeutic targets. This activity, and other factors such as their biological activity, the fact that they are privileged …