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Showing 1 to 20 of 35 for “"Indole alkaloids"”.
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Natural and synthetic bis-indole alkaloids as cytotoxic agents
… and purified and it proved to be a new bis-indole alkaloid. It was given the name tabernamine and showed an activity of 1.9 μg/ml (ED₅₀) in the PS in vitro system and a T/C % of 125 at a dose of 25 mg/kg in the PS in vivo system. In conjunction with these results and the knowledge of the …
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Phytochemical Investigations of Fungi: Hydrogen-Cyanide, Indole Alkaloids and Carbohydrates
… metabolites including hydrogen cyanide, indole alkaloids and reserve carbohydrates were investigated. The major emphasis of this study concerned the taxonomic significance and the mechanism of HCN production by microorganisms, especially fungi.
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N-hydroxytryptophan in synthetic approaches to indole alkaloids : a lustrum of n-hydroxytrypto-fun
Contains fulltext : 30078_nhydinsya.pdf (Publisher’s version ) (Open Access)
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Semi-Synthesis of Melodinine, Taberyunine, and Melosuavine Bis-Indole Alkaloids Through Chemical and Biological Methods
… K was completed from the monoterpene indole alkaloid (-)-tabersonine through regioselective enzymatic hydroxylation and Polonovski-Potier coupling. Regioselective borylation strategies were used to achieve meta-oxygenated derivatives of (-)-tabersonine for analysis in a Drosophila …
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Bioreactor design for scaleup of Catharanthus roseus hairy root cultures for production of indole alkaloids
… roseus is the source of the important anticancer indole alkaloids, vincristine and vinblastine. Hairy root cultures are an attractive alternative for the production of plant derived secondary metabolites. C. roseus hairy root cultures were established in our laboratory by A. rhizogenes mediated …
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The γ-tocopherol-like family of N-methyltransferases: A taxonomically clustered gene family encoding enzymes responsible for N-methylation of monoterpene indole alkaloids
… Apocynaceae accumulates thousands of monoterpene indole alkaloids (MIAs) which originate, biosynthetically, from the common secoiridoid intermediate, strictosidine, that is formed from the condensation of tryptophan and secologanin molecules. MIAs demonstrate remarkable structural diversity and …
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A Catharanthus roseus mutant with trace levels of secologanin and monoterpenoid indole alkaloids does not express BIS1/BIS2 transcription factors and fails to activate iridoid biosynthesis.
… roseus) is the sole source of the monoterpenoid indole alkaloids (MIAs) that result in several essential anti-cancer chemotherapies as well as being an important source for other MIA derived pharmaceutical agents. Most of the alkaloid and pre-alkaloid iridoid pathway has been elucidated, but some …
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Crystallization studies of Pictet-Spenglerases
… of medicinally important molecules. Monoterpene indole alkaloids from plants are an especially important source of therapeutic molecules. Due to the complexity of these molecules, biosynthesis of derivatives is an attractive way of obtaining molecules with potentially new or improved …
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Discovery, characterization, and rational design of the enzymes involved in monoterpene indole alkaloid biosynthesis in Madagascar periwinkle
… 130 structurally complex monoterpene indole alkaloids are produced, including the clinically used anti-mitotic drugs, vinblastine and vincristine. The common intermediate to all monoterpene indole alkaloids is strictosidine, the product of an asymmetric Pictet- Spengler condensation of …
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Substrate analogs to investigate alkaloid biosynthesis in Catharanthus roseus
Terpene indole alkaloids are a class of natural products produced by plants, many of which are used clinically for the treatment of human disease. Natural products, are not produced by the organism for the purpose of treating human disease and often tailoring of the natural product scaffold results …
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Application of Mn(III) Oxidative Cyclizations to Natural Product Synthesis
… Work on the construction of the core of several indole alkaloids from the genus Tabernaemontana, including tronocarpine, chippiine, and dippinine B, will be explored with utilization of manganese(III) cyclizations. Hopes of accessing an advanced common intermediate for each of these natural …
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Optimalios sarpaginų šeimos alkaloidų sintezės paieška /
… of macroline, sarpagine and ajmaline related indole alkaloids. As a consequence, the synthesis of congeners possessing oxygenated indole ring requires the optimization of enantioselective routes to the relevant oxygenated tryptophan analogues.By contrast, the potential of the …
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Discovery and bioactivity assessment of a peptide, QUB-1976, from the skin secretion of the Senegal running frog, (Kassina senegalensis)
… of compounds: biogenic amines, bufadienolides, indole alkaloids, peptides, and proteins. Among these four types, peptides and proteins are the most studied. All these peptides and proteins have been divided into different types according to their bioactivity. Among all types of peptides, AMPs …
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Cross-Coupling Chemistry as a Tool for the Synthesis of Diverse Heterocyclic Systems and Natural Products
… Related to the C-Ring of the Polycyclic, Indole Alkaloids Aspidophytine and Haplophytine'. The fifth publication has the title 'Syntheses of Structurally and Stereochemically Varied Forms of C7N Aminocyclitol Derivatives from Enzymatically-derived and Homochiral cis-1,2-Dihydrocatechols' …
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Cross-Coupling Chemistry as a Tool for the Synthesis of Diverse Heterocyclic Systems and Natural Products
… Related to the C-Ring of the Polycyclic, Indole Alkaloids Aspidophytine and Haplophytine'. The fifth publication has the title 'Syntheses of Structurally and Stereochemically Varied Forms of C7N Aminocyclitol Derivatives from Enzymatically-derived and Homochiral cis-1,2-Dihydrocatechols' …
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CH activation and CH2 double activation of indolines: towards the synthesis of aspidospermidine and aspidofractinine
… molecular framework unique to this class of indole alkaloids.<br/><br/>Aspidospermidine has previously proven an attractive target, with over 20 total syntheses completed. The hexacyclic framework of aspidofractinine has proven more challenging, with only 5 total syntheses to date. These …
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Exploiting alkaloid biosynthesis in Madagascar periwinkle to obtain natural product derivatives and new biocatalysts
… vincristine from Catharanthus roseus monoterpene indole alkaloid biosynthesis, and camptothecin derivatives from Ophiorrhiza pumila quinoline alkaloid biosynthesis, are anticancer agents currently used in the clinic. Strictosidine synthase is a key enzyme in the biosynthesis of these medicinal …
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Plant aromatic amino acid decarboxylases: Evolutionary divergence, physiological function, structure function relationships and biochemical properties
… impacting the synthesis of monoterpenoid indole alkaloids (including the pharmacologically active vinblastine and quinine), benzylisoquinoline alkaloids (including the pharmacologically active papaverine, codeine, morphine, and sanguinarine), and antioxidant and chemotherapeutic amides. …
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Activating Aldehyde C-H Bonds: Applications to Hydroacylation and Transfer Hydroformylation
… molecules, including macrolide antibiotics, indole alkaloids, steroids, and terpenes. Mechanistic studies revealed that a benzoate counterion acts a proton shuttle to enable transfer hydroformylation.
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