Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Indocyanine Green"”.
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Indocyanine Green J-aggregate Nanoparticles for Detection of Senescent Cells
… in this thesis the synthesis of J-aggregates of indocyanine green was explored with the aim to develop a high contrast photoacoustic probe. Reported methods of J-aggregate productions resulted in poorly characterized systems, and the addition of centrifugation steps during the purification …
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USE OF NEAR-INFRARED FLUORESCENCE WITH INDOCYANINE GREEN IN SMALL ANIMAL SURGICAL ONCOLOGY AND IN CADAVERIC ANATOMICAL STUDY
… through the use of fluorescent dyes such as indocyanine green (ICG). Although well-established in human surgery, its clinical application in veterinary surgical oncology is still developing. In recent years, however, interest in this technique has grown rapidly, highlighting its potential to …
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In Vivo Fluorometric Assessment of the Skin Microcirculation
… signals from an intravascular tracer, indocyanine green, and a diffusible tracer, sodium fluorescein, was developed. The indocyanine green signal is described by a physiologically-based pharmacokinetic model with a wash-in time constant inversely proportional to the blood flow. The …
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Novel NIR Endoscopic Techniques for Medical Imaging – An Investigation Considering both LED and LASER Excitation Sources
… endoscopy in order to image the fluorophore Indocyanine Green. The project was developed through collaboration with clinicians at Imperial College London, the company partner Cymtec Ltd and the University of South Wales for imaging cancerous tissue in the breast via minimally invasive …
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The Synthesis and Evaluation of Non-Targeted Near-Infrared Heptamethine Molecular Probes
… actively compared against the clinical standard Indocyanine Green (ICG) and its structural derivative New Indocyanine Green (IR-820). The ultimate aim being to identify dyes which can be used alongside the clinical standards. The compounds developed within this thesis are structurally based on …
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MULTIFUNCTIONAL SUPRAMOLECULAR DELIVERY SYSTEM FOR ENHANCING TUMOR IMMUNOTHERAPY
… with hydrophobic molecules lonidamine (LND) and indocyanine green (ICG). in additional, after functional modification, the formed nanoparticles allowed conjugation of proteins such as antibodies against programmed death-ligand 1 (aPD-L1, atezolizumab). These engineered carriers address challenges …
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HEPATIC DIFFERENTIATION OF HUMAN AMNIOTIC EPITHELIAL CELLS AND IN VIVO THERAPEUTIC EFFECT ON ANIMAL MODEL OF CIRRHOSIS
… ACTIVITIES, WERE ABLE TO UPTAKE AND CLEAR INDOCYANINE GREEN, AND UPTAKE LOW-DENSITY LIPOPROTEIN. AFTER CELLULAR TRANSPLANTATION INTO NSG MICE WITH THIOACETAMIDE INDUCED CHRONIC LIVER FAILURE, HAECS SHOWED ENGRAFTMENT AND CONTINUED TO SURVIVE ONE MONTH POST TRANSPLANTATION. LIVERS OF ANIMALS …
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Manipulating macrophages to enhance liver regeneration
… including quantification of hepatic clearance of indocyanine green by fluorescent imaging and assessment of hepatic phagocytic capacity using fluorescent microbeads. I then describe macrophage based therapeutic interventions in mouse models of liver injury. Firstly the direct administration of …
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Induction of Immunogenic Cell Death via Nanoparticle-Mediated Dual Chemotherapy and Photothermal Therapy
… with doxorubicin, a chemotherapeutic agent, and indocyanine green, a PTT agent that can absorb the light in near infrared (NIR) region and convert it to heat. NPs were characterized and confirmed to be suitable for agent delivery. Both types of NPs were shown to significantly reduce the viability …
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Preparation of multifunctional nanoparticles using microfluidics
… microfluidic production of fluorescent dye indocyanine green (ICG)-loaded liposomes was studied for potential imaging and photothermal applications. Lastly, encapsulation of hydrophobic superparamagnetic iron oxide nanoparticles (SPION) into LTSL was explored for their theranostic …
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UNDERSTANDING ANATOMICAL PERFUSION AND STRATEGIES TO OPTIMIZE VASCULARITY IN FREE TISSUE TRANSFER FOR AUTOLOGOUS BREAST RECONSTRUCTION USING THE DEEP INFERIOR EPIGASTRIC ARTERY PERFORATOR (DIEP) FLAP
… CTA and intra-operative Laser-Assisted Indocyanine Green Fluorescence Angiography (LA-ICGFA) were used to evaluate perforator anatomy and dynamic perfusion zones of individual perforators. Finally, an experimental in-vivo animal model was used to investigate strategies of pretreatment of …
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Effects of Metallic Nanoalloys on Dye Fluorescence
… acid) DNA microarrays. The emission intensity of indocyanine green — widely used as a contrast agent in medical imaging — was about twenty times higher in the proximity of SIFs. This enhancement phenomenon — due to the surface plasmon polaritons associated with the metallic NPs — can be explained …
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Skeletal Muscle Protein Metabolism and Molecular Responses to Endurance Exercise and Nutritional Interventions
… measurements and tracer incorporation), macro- (indocyanine green dye dilution and Doppler) and microvascular (contrast-enhanced ultrasound and microdialysis) techniques, immunoblotting, and hormone assays were used to examine skeletal muscle metabolism, leg blood flow and skeletal muscle …
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Shortwave infrared imaging and its translation to clinically-relevant designs
… dyes, including the FDA-approved contrast agent indocyanine green, exhibit optical properties suitable for in vivo SWIR fluorescence imaging, including intravital microscopy, noninvasive, real-time imaging in blood and lymph vessels, and tumor-targeted imaging with IRDye 800CW, a dye being tested …
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Engineering M13 Bacteriophage Nanoplatforms for Diagnostic and Therapeutic Applications
… is described. Chlorotoxin-phages, conjugate with indocyanine green dye (ICG), are visualized in-vivo in the second window near infrared (SWIR) and home effectively to mouse brain tumor. Ultra-short, 50nm chlorotoxin-phage particles are shown to vastly improve this localization specificity. …
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DEVELOPMENT AND APPLICATION OF MODIFIED HYALURONIC ACID DERIVED NANOPARTICLES FOR IMAGE GUIDED SURGERY AND DRUG DELIVERY
… with either the near infrared (NIR) fluorophore indocyanine green (ICG) for image guided surgery (IGS), or the fatty acid synthase (FASN) inhibitor Orlistat (ORL) for chemotherapy. Hydrophobic conjugates were synthesized and conjugated to HLA in order to drive self-assembly into nanoparticles …
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Development of Quantitative Molecular Photoacoustic Imaging For Noninvasive Cancer Diagnostics
… agent, liposome-encapsulated J-aggregated indocyanine green (Lipo-JICG), which is conjugated with anti-FRa antibodies for specific targeting to the FRa receptor on ovarian cancer cells. SO<sub>2</sub> was shown to have potential as a biomarker in disease progression of acute lymphoblastic …
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NANOTECHNOLOGICAL APPROACHES FOR CANCER DIAGNOSIS, TREATMENT AND MANAGEMENT: IMPLEMENTATION OF FERRITIN PROTEIN NANOPARTICLES FOR TUMOR TARGETING
… a HFn-based nanotracer for the delivery of indocyanine green (ICG), which is the main fluorescent dye currently used in clinics for FGS. A novel variant of HFn was developed, extensively characterized in vitro and loaded with ICG for in vivo experiments demonstrating potentiality as …
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Bio-Inspired Multi-Spectral Imaging Sensors and Algorithms for Image Guided Surgery
… in the NIR region—namely methylene blue (MB) and indocyanine green—which can help to identify tumor tissue due to passive accumulation in human subjects.</p> <p>The aforementioned advantages have led to the development of NIR fluorescence imaging systems for a variety of clinical applications, …
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