Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 28 for “"Indirect pathway"”.
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CD4 T cell allorecognition pathways in acute and chronic allograft rejection
… (recognition of intact allogeneic MHC) and indirect (recognition of self-MHC restricted allopeptide) pathways make to allograft rejection remains incompletely understood. In this thesis, murine models of heterotopic cardiac transplantation have been utilised to analyse these pathways. The …
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The Regulation of Effort Exertion by the Nucleus Accumbens Core
… are two main types of neurons, the direct and indirect pathway neurons, that play different roles in behavior and project to different downstream structures. The accumbens has also traditionally been divided into two subregions, the core and the shell. Much of what is known about these circuits …
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Modeling the Effects of Interparental Violence on Youth
… The goal of the study was to examine an indirect pathway of the effect of interparental violence on children's internalizing and externalizing problems. The data for the study was drawn from The Women and Family Project and included 359 women and one of their children between the ages of …
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Striatal Control of Sensory-Driven Behavior and Its Relevance for Neuropsychiatric Disorders
… TS neurons to identify how distinct striatal pathways contribute to sound-driven behavior. Both major striatal neuron types were active during reward-related target sounds, whereas non-target stimuli preferentially engaged neurons of the indirect pathway. Temporarily silencing these neurons …
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Genetic Dissection of Neural Circuits Underlying Value Based Decision Making
… two dominant cell types in the NAc, direct and indirect pathway medium spiny neurons (MSNs), showed partially overlapping but distinct behavioral effects. Inactivation of direct pathway MSNs showed the stronger effect on learning while inactivation of indirect pathway MSNs also showed the …
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Essays on the Long-term Effects of Childhood Chronic Conditions
… suggest educational attainment represents an indirect pathway. The second study investigates long-term implications of childhood chronic conditions in Canada using individual-level linked survey and tax data (National Longitudinal Survey of Children and Youth, T1 Family File). I find that …
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The adaptation and innovation model of organizational resilience
… and pointed towards the possibility of an indirect pathway between worker perceptions of their organization’s adaptability and their perceptions of its resilience.
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Striatal Microcircuits Underlying Control of Actions
… (Chapter 4) examined the role of direct and indirect pathways in velocity control during switching behavior in which animals were trained on a task with two different targets. Mice had to approach one target, then switch to another target to earn a reward. Direct pathway (striatonigral) …
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Poor Reading Ability as a Risk Factor for Alcohol Use in College Students
… without LD. One theory suggests that LD may be indirectly related to alcohol use, but there does not appear to be research examining whether there is a direct pathway between LD and alcohol use. The goals of this study were to better understand the relation between reading and alcohol use in …
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Acculturation and psychological distress among first generation Asian Americans : the roles of acculturative stress and social-cultural resources
… modeling with latent variables, direct and indirect influences on Asian immigrant psychological distress were examined. The findings indicate that higher acculturation was not directly associated with psychological distress for Asian immigrants, but there was an indirect pathway from higher …
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Relationships between flood frequency and riparian plant community structure in mountain streams of western Montana
… influenced vegetation characteristics by an indirect pathway through microtopography in all study areas, whereas the direct influence of flooding was found commonly only in three study areas. Other consistent direct influences included light (60%) and space (87%). Direct and indirect …
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Relationships between flood frequency and riparian plant community structure in mountain streams of western Montana
… influenced vegetation characteristics by an indirect pathway through microtopography in all study areas, whereas the direct influence of flooding was found commonly only in three study areas. Other consistent direct influences included light (60%) and space (87%). Direct and indirect …
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METHYLATED AMINE-UTILISING BACTERIA AND MICROBIAL NITROGEN CYCLING IN MOVILE CAVE
… the genera Catellibacterium and Mesorhizobium. Pathways for monomethylamine (MMA) metabolism were investigated using new PCR primers designed to target gmaS, the gene for gammaglutamylmethylamide synthetase, a key enzyme of the recently characterised indirect MMA oxidation pathway. This pathway …
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Till Death Do Us Part: Analyzing the Impact of Multiple Moral Violations on Parasocial Relationship Boundary Conditions
… that obtaining a PSR with the celebrity can indirectly result in higher moral disengagement through also obtaining a PSR with their character. This finding suggests that positive perceptions of a celebrity can provide an indirect pathway to enjoy morally ambiguous content, extending the …
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The role of dysfunctional peer relationships and academic failure in the development and progression of aggression
… aim of the present PhD thesis was to investigate pathways and processes involved in the etiology of aggression by examining the interrelation between multiple developmental problems in the peer and in the academic domain. More specifically, the relevance of affiliation with deviant peers as a …
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COMFORTABLE EXPLORATION: AN EXAMINATION OF THE LINK BETWEEN ATTACHMENT ANXIETY AND EMERGING ADULT RELIGIOUS BELIEF
… caregivers may translate into a correspondence pathway, in which the reported religious affiliation of the emerging adult corresponds to the parental religious affiliation (Granqvist, Mikulincer, & Shaver, 2010). At the same time, as attachment theory has traditionally been applied to affect …
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Serotonergic Circuits Mediating Stress Potentiation of Addiction Risk
… in Pdyn+, Adora2a+ and ChAT+ (markers for direct pathway, indirect pathway, and cholinergic interneurons, respectively). Following stress exposure, 5-HT1B transcript was selectively elevated in Pdyn+ cells of the mNAc. These findings suggest that Dyn/KOR regulates serotonin activation of 5HT1B …
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Principal Ownership of an Instructional Initiative: Advancing a Conceptual Framework for the Study of Leadership
… relationships are plausible. Significant pathways are found between the antecedents and the ownership behavior, and between the behavior and teacher collaboration. Mediational analysis of the pathways between principals' ownership behavior and the reform's reported influence on classroom …
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The Development and Application of Methods to Study the Evolution of Specificity, Allostery, and RNA -Protein Interactions in Translation
… This enzyme was found to be involved in the indirect pathway of cysteine aminoacylation that is shown to exist in the last universal common ancestral state. We have developed a network analysis based on molecular dynamics simulations in order to probe the mechanism and identify residues …
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Pathobiology of neuroinflammation and basal ganglia circuitry in Parkinson’s Disease
… preferentially expressed in neostriatal efferent pathways and PDE10A inhibitors (PDE10i) have been shown to target dopamine signaling mechanisms. Studies here have utilized PDE10i to understand the balance of activation of medium spiny neurons in the indirect pathway versus activation of the …
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