Global ETD Search
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Showing 1 to 10 of 10 for “"Incretins"”.
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Investigating the Role of Inflammatory Biomarkers and Incretins in the Aetiology of Type 2 Diabetes and Coronary Heart Disease using Human Genetics
… interleukin-6 (IL-6) proposed as a key player. Incretins such as glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) are hormones that stimulate a decrease in blood glucose. Their receptors are existing T2D drug targets, yet the efficacy and safety of GIP mono- and dual …
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Physiological, Morphological and molecular biological studies of the effect of Glucagon-like peptide-1 and exenatide in the diabetic rat pancreas
… study investigated the beneficial effects of incretins, substances such as glucagon-like peptide-1 (GLP-1) and its synthetic agonist, exenatide on the diabetic rat pancreas compared to healthy, agematched controls. These incretins exert their beneficial effects by repairing the pancreatic …
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G-Protein Coupled Receptors Modulating Incretin Hormone Secretion
… storage and GLP-1 has anorexic effects. Incretins are released from the gastrointestinal tract in response to food ingestion. Great interest exists on how to enhance secretion of these peptides for the treatment of diabetes and obesity, as injectable GLP-1 mimetics are now routinely used …
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Extrapancreatic actions of incretin-based therapies on bone in diabetes mellitus
… clear at present. The physiological actions of incretins are attenuated by dipeptidyl peptidase (DPP-4) activity and it is speculated that introduction of DPP-4 inhibitor may also positively affect quality of the skeleton. As such, this thesis evaluates the potential beneficial effects of a …
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Identification of a Dual-Action Small Molecule with Potent Anti-diabetic and Anti-obesity Activity
… for improving glycemic control in T2D patients. Incretins are gut hormones that possess potent insulinotropic action, which have drawn considerable attention in research and developing treatment strategy for T2D. Specifically, glucagon like peptide 1 (GLP-1), the most important incretin that is …
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Quantitation of enteroendocrine hormones as metabolic disease biomarkers in human biological matrices by liquid chromatography tandem mass spectrometry
… enteroendocrine cells (EECs) and some, known as incretins, are released after a meal to control blood glucose and stimulate neuronal satiety. These are being studied as novel targets for treatment of metabolic diseases such as obesity. Traditionally quantitative analysis of these hormones is …
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EXPOSURE TO STRESS EARLY IN LIFE AND ENHANCED RISK TO DEVELOP MOOD AND METABOLIC DISORDERS LATER IN LIFE: IDENTIFICATION OF THE COMMON PERIPHERAL AND CENTRAL MECHANISMS
… animals, such as leptin, insulin, ghrelin and incretins, were significantly different compared to controls. Taken together, these results could suggest a possible dysregulation of insulin signaling and glucose metabolism, hallmark of metabolic syndrome. Our findings shed light on the biological …
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Mechanisms underlying monosaccharide stimulated incretin hormone secretion from the intestine
… insulinotropic polypeptide (GIP), known as incretins due to their insulinotropic properties, are produced and released by the EEC sub types L-cells and K-cells respectively. The monosaccharide glucose is a trigger for incretin secretion, which requires glucose uptake via the sodium-dependent …
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Characterisation and pharmacological regulation of GLP-1-mediated glucose homeostasis
Type 2 diabetes mellitus (T2DM) is characterised by the hormonal imbalance of insulin and glucagon, leading to dysfunctional glucose homeostasis. Glucagon-like peptide 1 (GLP-1), which is an incretin hormone, activates the predominantly Gαs-coupled glucagon-like peptide 1 receptor (GLP-1R), which …
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The effect of whey protein on insulin and glucose responses in recreationally active males
The objective of the study was to analyze the insulinotropic and glycemic responses of hydrolyzed whey protein concentrate (WPH) in comparison to its intact form, whey protein concentrate (WPC), and carbohydrate control (CHO) in recreationally active young men over a 3-hr postprandial period. …