Global ETD Search
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Showing 1 to 10 of 10 for “"Incretin Hormones"”.
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Circadian Secretion of Glucagon-like Peptide-1
… establishing diurnal metabolic homeostasis. The incretin hormone glucagon-like peptide-1 (GLP-1) enhances glucose-stimulated insulin secretion following nutrient ingestion and has recently been shown to follow a circadian rhythm of secretion that parallels the expression of the core clock gene, …
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Relationships of gastric emptying with glycaemia, insulin secretion and the incretin effect in health and type 2 diabetes
… relationships between gastric emptying, incretin hormones (GIP and GLP-1) and postprandial glycaemic and insulinaemic responses in health and type 2 diabetes. Key themes relate to: 1) Evaluation of the relationships of ‘early’ and ‘late’ glycaemic responses with gastric emptying in …
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Self-assembled peptide as a long-acting drug formulation
… of hypoglycaemic excursions [2]. However, native incretin hormones are quickly degraded by peptidases and renally excreted, which has so far impaired pharmaceutical exploitation of anorectic and glucose-homeostatic activities [3]. It is known that many – if not all – peptides can be converted to …
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G-Protein Coupled Receptors Modulating Incretin Hormone Secretion
The incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), secreted from K-cells and L-cells respectively, augment insulin secretion. In addition, GIP facilitates triglyceride storage and GLP-1 has anorexic effects. Incretins are released from the …
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Physiology and pharmacology of diabetes therapies in the cat: insulin detemir, insulin glargine, exenatide and the incretin effect
… and poor compliance. Novel insulin analogs and incretin-based therapies are more effective and have fewer side effects than traditional therapies. We studied some of these novel therapies in healthy cats. We used the isoglycemic clamp method to compare the pharmacodynamics of the synthetic …
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Extrapancreatic actions of incretin-based therapies on bone in diabetes mellitus
… leading to increased bone fragility. The incretin hormones, with a classical effect to increase insulin secretion following food ingestion, are now postulated to have important direct effects on bone. As such, glucose-dependent insulinotropic polypeptide (GIP) has dual actions on bone …
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Cardiovascular risk reduction in insulin resistant states
… study the effect of rimonabant and metformin on incretin hormones in patients with PCOS was studied.The next studies focused on a randomised double blind placebo controlled study on the pleotrophic effect of atorvastatin in patients with PCOS. Subsequent metformin therapy after atorvastatin …
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Exploring the function and sensing mechanisms of human enteroendocrine cells using intestinal organoids
… only around 1% of the total gut epithelium. Gut hormones are released in response to cues of different natures to regulate several physiological events, such as nutrient digestion and absorption, intestinal motility, food intake, inflammation, and energy homeostasis. This thesis aimed to …
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Gut microbes and serum metabolomics in canine with diabetes mellitus
… promotion of inflammation, and altered incretin hormone responses. Enriching and diversifying an unbalanced gastrointestinal (GI) microbiome with fecal microbiota transplantation (FMT) may help improve gut function and glycemic control of diabetic dogs. The results presented herein are …
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A novel nutritional approach to the management of type 2 diabetes: effects of nutritional preloads on postprandial blood glucose and gastric emptying in type 2 diabetes mellitus
… mediated in part by the secretion of gut hormones. Gastric emptying is often disordered in people with type 2 diabetes; the emptying of solids and/or nutrient liquids is abnormally delayed in up to 30-50% with patients with longstanding type 2 diabetes, while gastric emptying may be …