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Showing 1 to 20 of 54 for “"Inclusion complexes"”.
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Polymorphs, cyclodextrin inclusion complexes and salts of the bronchodilator tulobuterol
… thesis was to prepare polymorphs, cyclodextrin inclusion complexes and salts of tulobuterol, a drug with bronchodilating properties. Polymorphic drugs are of interest to the pharmaceutical industry because of their varied physical properties, whilst the increase in aqueous solubilities of drugs …
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Improved Properties of Natamycin Upon Formation of Cyclodextrin Inclusion Complexes
… on the surface of the shredded cheese. Molecular inclusion complexes of natamycin were formed with β-, hydroxypropyl β-, and γ- cyclodextrins (CDs) which allowed large increases in aqueous solubility without the use of organic co-solvents or surfactants. The water solubility of natamycin was …
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Physicochemical study of solid Cyclodextrin inclusion complexes of the antithrombotic Ajoene
… and physicochemical characterization of inclusion complexes formed between selected cyclodextrins (CDs) and ajoene, an antlthrombotlc found in garlic. The E and Z isomers of ajoene (4,5,9,-trithiadodeca-1,6,11-triene-9-oxide) were reacted with α, β, γ-CD heptakis(2,6-di-O-methyl )-β-CD …
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The Nature of Active Sites in Catalytic Zeolites and Metal Dichalcogenide Inclusion Complexes
Made available in DSpace on 2014-12-13T20:10:50Z (GMT). No. of bitstreams: 1 8009187.pdf: 3477349 bytes, checksum: 890e0d717cec6a9569e3ac1d3407276c (MD5) Previous issue date: 1979
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Characterization and Synthesis of Cyclodextrin Inclusion Complexes and their Applications as Fluorescent Probes for Sensing Biomacromolecules
… that allows them to form stable host-guest complexes with lipophilic molecules. This combination of functionality and guest binding ability makes CDs important scaffolds for the design of functional supramolecular systems. This thesis explored the interaction of …
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Characterization of alpha-cyclodextrin inclusion complexes with trans-cinnamic acid in an acid-based beverage system
… was used as a host molecule to form an inclusion complex with the cinnamic acid molecule. The cinnamic acid: α-cyclodextrin inclusion complex was then characterized using phase solubility analysis, proton nuclear magnetic resonance (H-NMR), and solid inclusion. Phase solubility analysis …
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Effect of cinnamic acid-cyclodextrin inclusion complexes on populations of Escherichia coli O157:H7 and Salmonella enterica in fruit juices
… with α- or β-cyclodextrins, and if these complexes could be used to control bacterial pathogens in juices. Based upon phase solubility analysis, α-cyclodextrin was chosen as the host molecule for the remainder of this study. In complex with α-cyclodextrin, the solubility of cinnamic acid …
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Controlled Release of Natural Antioxidants from Polymer Food Packaging by Molecular Encapsulation with Cyclodextrins
… were to (1) form and characterize cyclodextrin inclusion complexes with the natural antioxidants, alpha-tocopherol and quercetin, (2) incorporate cyclodextrin inclusion complexes of natural antioxidants into linear low density polyethylene (LLDPE), and (3) measure the release kinetics of …
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Supramolecular modification of selected antitubercular drugs
… polymorphs, solvates, cyclodextrin (CD) inclusion complexes and cocrystals] and to isolate and characterise a range of solvated forms of the rifamycin antibioticsrifampicin and rifaximin.
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The supramolecular derivatisation of pharmaceutically relevant compounds via co-crystallization and cyclodextrin inclusion complexation
… via co-crystallization and cyclodextrin (CD) inclusion complexation was attempted in order to produce new solid forms of these compounds for potential pharmaceutical applications. The pharmaceutically relevant compounds investigated included (a) three drug leads, namely …
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Crystal isostructurality and X-ray diffraction studies of cyclodextrin inclusion compounds
… part of this dissertation includes organic inclusion complexes of all three natural cyclodextrins (a-,
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Synthesis and characterisation of new multi-component compounds containing the non-steroidal anti-inflammatory drugs fenbufen and S(+)-ibuprofen
… synthesise salts, co-crystals and cyclodextrin inclusion complexes containing these drugs. All newly discovered phases were characterised using single-crystal X-ray diffraction (SCXRD), powder X-ray diffraction (PXRD), hot stage microscopy (HSM), Fourier transform infrared (FT-IR) spectroscopy, …
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Supramolecular derivatives of selected bioactive compounds : a physicochemical study
… [polymorphs and cyclodextrin (CD) inclusion complexes], its derivative 2-methoxyestradiol-bis-sulfamate (polymorphs), and the antiretroviral agent, nevirapine (co-crystals). The solubility and dissolution profiles of the three compounds and those of selected …
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Drug-cyclodextrin complexes: an approach to enhance the solubility and dissolution properties of poorly soluble drugs
… manufacturing processes claimed to promote inclusion complexation between different drugs and cyclodextrins (econazole and α-cyclodextrin; indomethacin and methyl-β-cyclodextrin; olanzapine and methyl-β-cyclodextrin; flurbiprofen and methyl-β-cyclodextrin) in order to enhance the apparent …
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The supramolecular modification of trans-resveratrol and related antioxidant molecules
… These properties may be improved by inclusion complex formation with cyclodextrins (CDs) and by cocrystallisation with generally regarded as safe (GRAS) coformers. A study of the CD complexation of RES, CAF, FA, PCA, SA, 2H4M and 4H3M was carried out both in solution and in the solid …
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Preparação e caracterização de complexos multicomponentes contendo ciclodextrinas e benznidazol
… aqueous solubility, as well as the formation of inclusion complexes was also investigated. The interactions in solution were predicted and investigated using phase solubility diagram methodology, nuclear magnetic resonance of protons (RMN) and molecular modeling. Complexes were obtained in solid …
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Physicochemical studies of the inclusion of selected agrochemicals in cyclodextrins
… the thermal stabilities of three isostructural inclusion complexes were evaluated using thermogravimetric analysis.
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Complexation between cyclodextrins and phenylurea herbicides in solution and in the solid state
… author undertook the preparation of cyclodextrin inclusion complexes of four phenylurea herbicides (metobromuron, monolinuron, monuron and fenuron) using the kneading and co-precipitation methods in the solid state while also determining complex formation of the same phenylureas in solution with …
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Inclusion of alkylparabens in cyclodextrins
The aim of this thesis was to prepare crystalline inclusion complexes with cyclodextrins (CDs), as hosts, and drugs, as guests, characterise them using various methods and attempt to elucidate their structures by X-ray diffraction methods to establish the detailed mode of drug inclusion in the …
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