Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"Inbred strains"”.
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Postnatal Testicular Development in 3 Inbred Strains of Mice.
… characteristics of male gonads between strains of inbred mice (Shire and Bartke, 1972; Hayward, 1973: Eleftheriou and Lucas, 1974). Shire and Bartke noted marked variations in both the absolute and relative postnatal testicular weights in 11 strains from 56 to 112 days of age. The …
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Use of Inbred Strains for the Study of Individual Differences in Pain Related Phenotypes in the Mouse
… of genotypic and phenotypic information about inbred strains of laboratory mice is being collected and assembled in large databases. Sophisticated mining of this information can be useful in generation of hypotheses regarding the sources and nature of phenotypic variability, both environmental …
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The Interaction of a Mutant Gene, Paddlefoot (Pf), and a Teratogen, 6-Azauridine, on Limb Development in Two Inbred Strains of Mice.
… or teratogen alone, varies between different strains of the same species (Landauer, 1960). These differences are attributable to the action of many genes operating together rather than to the action of a single gene. (2) Teratogens, which induce phenotypic effects similar to mutant genes, may …
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Insights into the piRNA pathway through 16 strains of mice
… The study encompasses data from 16 unique inbred strains, 12 classical inbred strains and 4 wild inbred strains, studied across three pivotal developmental timepoints in germ cell development and piRNA biogenesis: E16.5, P12.5, and P20.5, in biological triplicates. Through a differential …
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Genetic Analysis of Variation in Neuron Number
… contributing to variation in neuron number among inbred strains of mice. I have focused on variation in neuron number on a large scale, by using the surrogate measure of whole brain weight, and variation within a distinct neuron population, retinal ganglion cells.</p> <p>Brain weight ranges from …
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Functional Analysis of Genomic Variation and Impact on Molecular and Higher Order Phenotypes
… we resequenced the genome of one of the oldest inbred strains of mice—DBA/2J—the father of the large family of BXD recombinant inbred strains. We analyzed ~100X wholegenome sequence data for the DBA/2J strain, relative to C57BL/6J, the reference strain for all mouse genomics and the mother of …
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Pathological and genetic analysis of host susceptibility to cardiovirulent coxsackievirus B3 infection in mice
… phenotypic traits were characterized. Three inbred strains of mice and two congenic strains were infected with CVB3. Differences in survival, body weight loss, quantification of myocarditis and quantification of sarcolemmal disruption were found by comparing three sets of mice sharing the …
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The Effect of Storage on Activity of Murine Tnf-α: a Comparison of Inbred and Outbred Strains
… inflammationa and possible septic shock. Inbred strains are the preferred odel to study macrophage production of TNF-α because they are genetically homogeneous. The dimorphic yeast, Candida albicans, is an opportunistic pathogen that elicits a macrophage response and subsequent release of …
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INVESTIGATION OF GENETIC FACTORS DETERMINING ISCHEMIC STROKE OUTCOME
… First, we screened infarct volumes across 32 inbred mouse strains. The infarct volume varies between strains, and this strongly suggests that infarct volume is genetically determined. To identify these genetic factors, we used genome-wide association study [Efficient Mixed-Model Association …
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A T cell receptor transgenic approach to the study of thymocyte development and autoimmune disease
… and antigen. Interestingly, only certain inbred strains of mice developed the disease. The phenotype of transgenic cells differed from affected to unaffected animals. Analysis of these mice could reveal novel genetic factors that influence T cell responses. Furthermore, these mice may also …
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The identification and characterization of two murine genes regulated by the level of dietary fat
… to type and amount of dietary fat in two inbred strains of mice with different susceptibilities to disease. Scd1 mRNA expression significantly ($P<$ 0.05) decreased in BALB/c mice fed diets containing 20% corn or coconut oil compared to those fed 4% of these fats in otherwise identical …
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Medaka fish as a model for complex trait genetics
… the medaka fish (Oryzias latipes) and the Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel — a genetic resource established by my supervisor, Prof. Ewan Birney, and collaborators — to investigate the genetic architecture of complex traits, with a particular focus on non-additive genetic effects. My …
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Expression and glycosylation of meprin isoforms
… and is expressed in random-bred and some inbred strains of mice. Meprin B contains subunits of 110 kDa (β subunits) <i>in situ</i>, and the enzyme from C3H/He mice, a strain that does not express α subunits, has been characterized. Evidence from this and previous studies indicate that β …
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A Critical Review of Telomerase Biology and Model Systems for the Study of Telomerase
… and cancer is of particular importance. While inbred strains of mice have provided a wealth of information for a variety of pathways and diseases, the mouse model poses a challenge for the study of telomere biology due to their extremely large telomere sizes. The telomerase knockout mouse …
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Cellular and Genetic Basis for the Resistance of BALB /Cj and 129S1 /Svimj Mice to Yersinia Pestis
… highly lethal pathogen. We challenged several inbred strains of mice with Y. pestis and found that BALB/cJ mice are highly resistant compared to susceptible strains such as C57BL/6J. Resistance is seen within 24 hours post infection. In an effort to identify gene(s) responsible for resistance …
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Haplotype-Specific Effects of the Slam/Cd2 Family on the Immune Response
… two stable haplotypes in a panel of 33 common inbred strains of mice. The first haplotype is only found in B6 and other C57- related strains. The more common second haplotype is found in Sle1b and other autoimmune strains such as MRL, NOD, and NZB, as well as non-autoimmune strains such as …
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Characterization of the effects of Interferon gamma protein-10 (CXCL10) against the protozoan parasite Leishmania amazonesis
… amazonensis causes progressive disease in most inbred strains of mice. We have previously shown that L. amazonensis-infected C57BL/6 mice have profound impairments in expression of pro-inflammatory cytokines, chemokines and in activation of antigen-specific CD4+ T cells. These impairments are …
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The genetics of atrial septal defect and patent foramen ovale
… locus for this disorder. Previous studies of inbred laboratory mice showed an association between patent foramen ovale (PFO) and measures of atrial septal morphology, particularly septum primum length (“flap valve length” or FVL). In humans, PFO is associated with cryptogenic stroke and …
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Studies on the Inheritance of Idiotypic Markers of Mouse Antibody to Streptococcal Group A Carbohydrate and on Other Genetic Factors Which Influence the Immune Response
… A streptococcal carbohydrate was measured in 10 inbred mouse strains after immunization with whole heat-killed streptococcal vaccine. Using A/J and SWR/J mice, dose response studies were performed to determine optimai immunization conditions of dose, route of injection, and age of mice. In the …
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