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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Inbred Mice"”.
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A chromosomal analysis of bone marrow cultures of inbred mice
Adult CBA mice at 0, 50, 73, and 90 percent levels of inbreeding were used to study variation's in chromosome number from bone marrow cells. Chromosome counts were made from 20 animals at each level of inbreeding except at the 73 percent level where only 13 animals were available. The chromosome …
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Genetic Variation and Sex Mediate Differential Responses to ∆-9-tetrahydrocannabinol among Inbred Mice
… cannabis, between highly genetically divergent inbred mouse strains—C57BL/6J (B6) and DBA/2J (D2). To identify variation in THC response we use the cannabinoid-induced tetrad test which quantifies the strength of agonist mediated cannabinoid receptor signaling by measuring the level of motor …
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Systems Genetics and Systems Biology Analysis of Paraquat Effects in BXD Recombinant Inbred Mice
<p>Paraquat (PQ) is a chemical herbicide that is used in many countries including the United States. It is also highly acutely toxic to humans and has been used as a means of suicide. As PQ is applied mainly in agricultural settings, it moves to soil and well water. Chronic low dose exposure via …
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Effects of selenium and vitamin B-6 on growth of chemically- induced transplanted tumors in BALB/c inbred mice
Male weanling inbred, mice were inoculated with fibrosarcoma cells (hindquarter) originally produced by 2-methylcholanthrene. Before inoculation, mice were randomly divided into three groups of 24 and one of 12 (control). After a one week acclimation period, each group was fed a diet containing …
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Effects of Genetics and Sex on Hippocampal Gene Expression and Adolescent Behaviors Following Neonatal Ethanol Exposure in BXD Recombinant Inbred Mice
… the hippocampus after ethanol exposure. Neonatal mice were treated on postnatal day 7 (third trimester equivalent in humans). Animals received a subcutaneous injection of either 5.0g/kg ethanol in saline solution or isovolumetric saline given in two equal doses two hours apart. Animals were …
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Effects of Long-Term Exposure of Normal C57BL/6J Inbred Mice to 17β-Estradiol on Gene Expression in Lymphocytes: mRNA Analysis of Lymphokines and bcl-2/fas
… compared to lymphocytes from placebo-treated mice. IL-2 and IFN-g mRNA was consistently higher in ConA-stimulated lymphocytes from estrogen-treated mice (P < 0.05). The mRNA for TGF-β₁ lymphokine was also increased but was not consistent at all time points of incubation. The expression of IL-4 …
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Genetic Regulation of Intrinsic Endurance Exercise Capacity in Mice
… for endurance exercise capacity in 34 strains of inbred mice using genome-wide association mapping. 2) The effect of chromosome substitution on endurance exercise capacity using linkage analysis in F2 mice. 3) The effect of chromosome substitution on endurance exercise capacity using wild-derived …
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In Vitro and In Vivo Studies on Bone Formation
… <p>The first study compared two strains of inbred mice, one with high bone density and one with low bone density, to determine when and to what extent bone density accumulation during postnatal and pubertal growth contributed to the observed differences in bone density between the two …
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Development of the Limb in Mice Bearing the Mutant Gene: Hypodactyly (Hd).
… and the expressivity in two strains of inbred mice of a mutant gene: Hypodactyly, whose principal manifestation is a numerical reduction of the hindlimb digits.In 1966, Hypodactyly (symbol Hd; linkage group XI) occurred spontaneously in the inbred strain MYA/Hu (Hummel, 1971). Since the …
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Postnatal Testicular Development in 3 Inbred Strains of Mice.
… of male gonads between strains of inbred mice (Shire and Bartke, 1972; Hayward, 1973: Eleftheriou and Lucas, 1974). Shire and Bartke noted marked variations in both the absolute and relative postnatal testicular weights in 11 strains from 56 to 112 days of age. The relative weight …
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Profiling, prototyping, and perturbing human immune responses
… of human samples, shifting focus away from inbred mice and allowing an alternative research framework to emerge. This approach aims to ‘reverse-engineer’ the human response by finding disease-relevant biological phenomena through deep phenotyping of humans and using insight from patients to …
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Pathological and genetic analysis of host susceptibility to cardiovirulent coxsackievirus B3 infection in mice
… B, type 3 (CVB3) infection. CVB3 infection of mice provides a useful model to study pathogenic mechanism of myocarditis. The objective of this study is to test the hypothesis that susceptibility, during the acute CVB3 infection, is under polygenic control including H2 as well as the non H-2 …
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Peripheral Taste System in Inbred Mouse Strains
Taster and non-taster mice strains have been used extensively in animal taste research. Inbred mouse strains C57 and FVB have been proposed to be tasters, where as strains 129 and Balb/C are classified as non-tasters. Therefore, evaluating the peripheral taste system in these mice is of great …
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Multiscale Genomic Analysis of the Corticolimbic System: Uncovering the Molecular and Anatomic Substrates of Anxiety-Related Behavior
… controls emotionality. Using BXD recombinant inbred (RI) mice as model organisms, the anatomy and cellular architecture of the amygdala—specifically, the basolateral amygdala (BLA)—was examined to assess the level of structural variation in this brain region. Quantitative trait locus (QTL) …
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Voluntary exercise in the C57B1/6J mouse: phenotypic effects of varying dietary fat levels and hippocampal gene expression differences between high-level and low-level exercisers
… to deter dietary-induced obesity and that in an inbred strain of mice, environmentally sensitive genes must be responsible for observed differences in individual voluntary exercise performance. To study this theory, we have designed a set of experiments that establish an animal model to address …
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Potentiating effects of caffeine on the teratogenicity of acetazolamide in two strains of mice
… in susceptible and resistant strains of inbred mice. The highly susceptible C57BL/6J and more resistant SWV strain were used. Pregnant C57BL/6J and SWV mice were treated with caffeine, low or high dose acetazolamide, or a combination of both agents during the sensitive period of …
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Integrated Genomics Of Susceptiblity To Therapy-Related Leukemia
… susceptibility to therapy-related leukemias in mice, little is understood either about the contributing loci, or the mechanisms by which susceptibility factors mediate their effect. An improved understanding of susceptibility factors and the biological processes in which they act may lead to the …
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Gray matter covariance networks in the mouse brain
… cohort of genetically-homogeneous wild-type mice (C57Bl6/J). To this purpose, I first developed a semi-automated pipeline enabling reliable Voxel Based Morphometry (VBM) of gray matter volumes in the mouse. To validate this approach and its ability to detect plastic changes in brain …
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Strain-dependent and age-dependent effects of acute, chronic, and withdrawal from chronic nicotine on fear conditioning.
… on fear conditioning in 8 strains of inbred mice. Furthermore, nicotine withdrawal-related changes in somatic signs and the elevated plus maze were examined because nicotine withdrawal consists of multiple symptoms that can include increased somatic signs and increased anxiety. …
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