Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"In-stent restenosis"”.
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The role of altered cyclic strain patterns on proliferation and apoptosis of vascular smooth muscle cells - implications for in-stent restenosis
Currently, Percutaneous Transluminal Coronary Angioplasty (PTCA) followed by stent implantation is the frontline treatment in the management of coronary artery disease. To-date the main drawback of stent implantation is in-stent restenosis. Restenosis is a partial re-occlusion of the arterial wall …
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Experimentelle Untersuchungen am porzinen „over-sized coronary stent“-
Experimental investigations at the porcine over-sized coronary stent-model for in-stent-restenosis rate after implantation of uncoated niob-zirkonium stents and niob-zirkonium stents coated with iridiumoxide. Background: The treatment of atherosclerotic stenosis in coronary artery disease with …
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Clinical outcome and Predictive factors of Coronary aneurysm after Percutaneous Coronary Intervention
Coronary artery aneurysms (CAAs) defined as angiographic luminal dilatation (50% larger than the adjacent reference vessel) at the site of stent implantation are rare and the reported incidence varies from 0.3% to 6%(Aoki et al., 2008). A new term, peri-stent contrast staining (PSS) was defined as …
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Modeling and simulation of coronary stents: Intravascular drug delivery and arterial drug distribution
In-stent restenosis still occurs in coronary arteries implanted with drug-eluting stents, with the maximum thickness observed at the vascular site of maximum inter-strut angle. This phenomenon may be related to the specific spatiotemporal drug uptake in the arterial wall. In this work local …
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Novel strategies for optimising drug release from medicinal implants
In-stent restenosis (ISR) is a significant limitation of percutaneous coronary revascularisation procedures, occurring in around 30% of patients. Implantation of the sent produces an intense inflammatory response. This leads to high levels of smooth muscle cell (SMC) proliferation and migration, …
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Prospektive randomisierte Untersuchung der Neointimaproliferation in goldbeschichteten Koronarstents im Vergleich zu herkömmlichen Edelstahlstents mittels intravaskulären Ultraschalls
In-stent restenosis is a major limitation of percutaneous coronary interventions and occurs due to neointimal hyperplasia after stent implantation. Gold coating of stainless stell stents showed an in-vitro-reduction of neointimal formation, an effect attributed to an assumed favourable …
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Construction of nano-assembled microcapsules embedded with gold nanoparticles for use in novel drug delivery systems
Coronary stents have changed the way in which coronary artery diseases are managed. Although bare-metal stents can be traced back to 1994, long term efficacy of these stents has been shattered by ISR (In-Stent restenosis) and late stent thrombosis. Research on finding a solution to these issues has …
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Mathematical modeling and simulation of intravascular drug delivery from drug-eluting stents with biodegradable PLGA coating
Drug-eluting stents (DES) are commonly used in coronary angioplasty procedures. A DES elutes drug compounds from a thin polymeric coating into the surrounding coronary artery tissue to reduce in-stent restenosis (a significant lumen loss due to growth of vascular tissue). Biodurable (non-erodible) …
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Crosstalk Signaling Between cAMP and Calcium on the Leading Edge of Migrating Human Arterial Vascular Smooth Muscle Cells
… phenotypically plastic. Thus, while the VSMCs in healthy blood vessels are ‘contractile’ and control vascular tone, these cells can increase their synthetic, migratory and proliferative capacities in response to vessel injury. While largely adaptive, actions of “synthetic” VSMCs can promote …
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Hochfrequenzrotablation zur Behandlung von Restenosen in Koronarstents
This thesis examines the mechanisms of acute lumen enlargement after rotational atherectomy (RA) in case of an in-stent restenosis (ISR) and it assesses the results of adjunct balloon angioplasty (BA) and describes the predictors for a recurrent restenosis. ISR has become an important implication …
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Etablierung und Charakterisierung eines diabetischen Tiermodells zur Stent-Restenose
… Diabetic patients have a greater risk of developing coronary artery disease as well as restenosis following coronary stent implantation than non-diabetics, despite tremendous advances in the fields of diabetology and invasive cardiology. Surprisingly, no acceptable diabetic animal model of …
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Bleeding Risk Following Percutaneous Intervention in Patients with Diabetes Prescribed Dual Anti Platelet Therapy
… with diabetes (DM) experience higher rates of in-stent restenosis and therefore greater benefit from drug eluting stent (DES) implant at the time of percutaneous coronary intervention (PCI). DES stent implantation necessitates prolonged dual anti-platelet therapy (DAPT). While DAPT reduces the …
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Development and characterization of advanced nitric oxide-delivering polymeric systems against cardiovascular complications
… cardiovascular disease related deaths worldwide. In this thesis project the role of normative tissue mineral concentrations in native and decellularized valves were studied in correlation with clinical patterns of acquired dystrophic calcification to understand the pathogenesis of the disease. …
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Investigating the Mechanisms Underlying the Heterogeneous VSMC Contribution to Vascular Disease
In healthy blood vessels, vascular smooth muscle cells (VSMCs) exist in a contractile, quiescent state but upon vascular insult can switch phenotype to activate proliferation, migration and remodelling of the extracellular matrix. Phenotypically switched VSMCs contribute most cells within …
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The safety and efficacy of novel dual function coronary stent in porcine model of myocardial infarction
Objectives: We aimed in this study to evaluate the effectiveness of a dual function coronary stent in both inhibiting In Stent Restenosis (ISR) and salvaging the injured myocardium following acute myocardial infarction in pigs. Background: For more than a decade, drug eluting stents have written a …
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Surface modification of traditional and bioresorbable metallic implant materials for improved biocompatibility
… a variety of metal alloys are commonly used in medical implants. Traditionally, corrosion-resistant metals have been preferred. These permanent materials can cause negative systemic and local tissue effects in the long-term. Permanent stenting can lead to late-stent thrombosis and in-stent …
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Η επίδραση των εμποτισμένων με διάφορες φαρμακευτικές ουσίες μεταλλικών ενδοπροθέσεων στο τοίχωμα των νεφρικών αρτηριών
… Σε 15 αρτηρίες ένα απλό μεταλλικό 3,5x18 mm R-stent τοποθετήθηκε (ομάδα A), ενώ για τις υπόλοιπες χρησιμοποιήθηκε ενδοπρόθεση εμποτισμένη με πακλιταξέλη, 3x32 mm T-stent (ομάδα B). Η βατότητα των αγγείων μελετήθηκε με ψηφιακή αφαιρετική αγγειογραφία, αξονική αγγειογραφία και εικονική …
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Ενδοαγγειακή απεικόνιση των αγγείων κάτωθεν του βουβωνικού συνδέσμου με Οπτική Συνεκτική Τομογραφία (Optical Coherence Tomography)
… διαμέτρου έως 4mm και δεν είχε εφαρμοστεί in vivo στα αγγεία των κάτω άκρων, κάτωθεν του επιπέδου των βουβώνων. Σκοπός της παρούσας μελέτης είναι να αναφερθεί για παγκοσμίως πρώτη φορά η ασφάλεια και η σκοπιμότητα της απεικόνισης με Οπτική Συνεκτική Τομογραφία του αρτηριακού άξονα των κάτω …