Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"In-Cell NMR"”.
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Proteins Inside Cells and On the Surface of Membranes: Developing Three Dimensional In-Cell NMR and Structural Characterization of a Trimeric Membrane Proximal External Region Construct from HIV-1 gp41
… complex biological processes is enhanced by studying the components of those processes at atomic resolution. Major advancements in technology and methodology have been made that continue to improve our ability to determine atomic resolution structures of proteins. These advancements have also …
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Structural Biology in Cellular Environments Using Sensitivity Enhanced NMR
… the general applicability of DNP solid state NMR to mammalian cells. DNP NMR can detect proteins at their physiological concentrations within cellular environment in tractable times. However, these experiments were limited to cellular lysates, which did not recapitulate the intracellular …
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Developing Magnetic Resonance Based Analytics to Support Continuous Bioprocess
… improve our ability to produce therapeutic proteins of appropriate quality and quantity. The aim of this research is therefore to explore the extent to which NMR techniques can be used to quantify the ratio of intra and extracellular proteins present in a biopharmaceutical production line; with …