Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"In vivo test"”.
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Electrospun membranes for implantable glucose biosensors
… thesis was to apply electrospun biomimetic coatings on implantable glucose biosensors and test their efficacy as mass-transport limiting and tissue engineering membranes, with special focus on achieving reliable and long sensing life-time for biosensors when implanted in the body. The 3D …
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Diterpenos com atividade antitumoral frente células leucêmicas: uma revisão.
The use of plants for medicinal purposes to treat, cure and prevent disease, is one of the olde st medicinal practices of mankind. P lants represent the largest sources of active substances that can be used in therapy due to the high structural diversity of metabolites produced and , because of …
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Bio-medicinal application for plasma electrolytic oxidation of metals
… oxidation (PEO), a novel method for forming ceramic coatings on metals, has been researched extensively in recent times. By applying high voltage between dielectric thin films, a plasma micro-arc is induced through penetration of breakdown in film boiling layer. Such a method takes …
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Assessing Intestinal Absorption of Amino Acids Utilizing an Isotope Based Approach
The purpose of this research was to further test a stable isotope based approach as a more reliable in vivo method to determine amino acid bioavailability from a variety of ingredients. The method was used to assess feather meal (FM), blood meal (BM), soybean meal (SBM), and a rumen protected amino …
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Biomechanics of the cerebrum at finite strain : a tissue and cell level study/
The present study addresses the large strain nonlinear mechanical response of the cerebral cortex at the macroscopic tissue level and at the microscopic cell level. Unconfined uniaxial compression tests were conducted in vitro on cortical samples of porcine brains. The tests consisted of …
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In vitro and in vivo effects of sorghum condensed tannins encapsulated in kafirin microparticles on digestive amylases
The International Diabetes Federation reported that by 2035 the expected increase in diabetes in sub-Saharan Africa will be 109%, the highest rise in the world. Furthermore, almost a quarter of the world‘s adult population have the metabolic syndrome. One therapeutic approach for type 2 diabetes …
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Effects of endocrine disruptors in zebrafish (Danio rerio) as revealed with the fish sexual development test
So-called “endocrine disrupting chemicals” (EDCs) are ubiquitous in the environment, especially in aquatic systems close to industrial and agricultural areas. Disturbances of the hormonal balance between estrogens and androgens are one central target of EDCs. Especially during sexual …
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Investigation of in Silico Modelling to Predict the Human Health Effects of Cosmetics Ingredients
… method to assess the safety of chemicals used in cosmetic products for decades. However, public opinion has continued to demand that in vivo hazard identification methods conducted on animals are replaced with alternative methods. Research on alternative methods to replace in vivo toxicity …
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Development of an inverse FE modelling method for material parameters identification based on indentation tests
In this work, an inverse FE modelling program based on the Kalman filter technique has been developed and used to study three material models (linear elastic, hyperelastic and hyper foam). Two error treatment methods have been developed and implemented in the program and their feasibilities for …
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Development of in silico models to support repeat dose safety assessment of cosmetic ingredients to humans
… to ensure that these products, and their ingredients, do not cause any adverse human health effects under normal usage; to ensure this, risk assessment must be performed. Traditionally, risk assessments are performed in vivo, i.e. conducting tests on animals using the chemical(s) of …
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Wireless Electrostimulation to Eradicate Bacterial Biofilms
… implants and cause serious device-associated infections that are incurable by conventional antibiotics because of high-level tolerance to antimicrobials. Common strategies for controlling device-associated infections, such as coating with antimicrobials and modification of surface properties, …
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A study on endocrine disrupters in the environment through the microarray technology
… of exposure to natural and synthetic compounds in our daily life, the debate concerning the safety of many substances is becoming increasingly relevant. The estrogenic activity of various compounds, described as xenoestrogens, is the major part of this debate. Humans beings are exposed to these …