Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 107 for “"In vivo study"”.
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An in vivo study of chromatin compaction in human cells
Chromatin was one of the first sub-cellular structures to be described in early microscopy studies (Heitz 1928). Chromatin is formed from DNA, RNA, histones and other associated proteins. Within the nucleus, chromatin is arranged as compacted heterochromatin and decompacted euchromatin. During cell …
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Protein Misfolding and Aggregation in Neurodegeneration: In Vitro And In Vivo Study Cases
Neurodegenerative diseases are nowadays increasing in incidence and widely distributed around the world. Despite those disorders show very different symptoms and morbidity, intracellular and extracellular protein misfolding and accumulation appears as a common pathological pathway. In the present …
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Radiologic, Histologic and Functional Evaluation after Implantation of Cultured Trachea Allograft : in vivo study
BACKGROUND: Commonly known as praying about how hard of a reconstruction, cartilage grafts, anastomosis country EP and the glass plate or Sophie. The sum of the areas of narrowing it after removing the door if possible, all the way to the ideal treatment in patients with anastomosis hard liquor, …
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An in vivo study of novel genetic modifiers in autosomal recessive polycystic kidney disease (ARPKD)
… and pulmonary hypoplasia, with death reported in around 30 – 50% of affected neonates. Mutations in PKHD1 and DZIP1L have been identified as causative genes for ARPKD, with the protein products of both genes localising to the primary cilium. Ciliary signalling pathways, such as Wnt signalling, …
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Importance of Pumice Prophylaxis for Orthodontic Bonding with Self-etch Primer: An in vivo Study
Self-etching primers (SEP) have recently simplified the orthodontic bonding process and questions have arisen regarding their reliability and efficiency. The goal of this study was to assess the importance of a pumice prophylaxis prior to bonding with SEP (Transbond Plus, 3M Unitek, Monrovia, CA) …
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Comparison of Two Orthodontic Sealants in Prevention of Enamel Demineralization : An In-Vitro and In-Vivo Study
Introduction: Enamel demineralization adjacent to orthodontic brackets is one of the risks associated with orthodontic treatment. Among the techniques utilized to prevent demineralization, application of orthodontic sealants is widely used to provide mechanical coating and fluoride release for the …
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An in vivo study of GTF2IRD1 function and its contribution to the physical features of Williams Beuren Syndrome
… genetic disorder caused by a hemizygous deletion involving up to 28 genes on chromosome 7q11.23. Amongst the spectrum of physical and neurological defects of WBS, it is common to find sensorineural hearing loss (SNHL) and a characteristic set of facial features. The gene GTF2IRD1, first discovered …
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Neuroprotective and immunomodulatory properties of the new PPARγ agonist MDG548: an in vitro and in vivo study in PD models
Neuroinflammation is a key component of Parkinson’s disease (PD) neuropathology. Skewed microglia activation with pro-inflammatory prevailing over anti-inflammatory phenotypes may contribute to neurotoxicity via the production of cytokines and neurotoxic species. Therefore, microglia polarization …
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In vivo study of the expression of the genes serA and gltD regulated by Lrp (Leucine-responsive regulatory protein) in Escherichia coli K-12
The plasmid pBAD22 lrp $\rm Cm\sp{R}$ carrying the lrp coding region immediately downstream from the $\rm p\sb{BAD}$ promoter was used to vary intracellular concentrations of Lrp. The expression of the genes serA and gltD was determined in the presence of different concentrations of Lrp. The …
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ms-Scale temporal coding in the thalamus predicted by whisker dispersive vibrational transduction
Whether stimulus information is encoded in the whisker system has been a question of debate. Considering the remarkable temporal precision in the whisker system with spike timing as small as 10μs, there is potential for ultrahigh capacity information channel in kb/s. To study temporal structures in …
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Die osteoinduktive Potenz verschiedener gentechnisch modifizierter Bone Morphogenetic Proteins : Eine vergleichende Untersuchung im Rattenmodell
In der vorliegenden experimentellen Studie wurden verschiedene BMP-Wildtypen und gentechnisch modifizierte Bone Morphogenetic Proteins in vivo im Kalottentrepanationsdefekt bei adulten Ratten hinsichtlich ihrer osteogenen Potenz untersucht. Für alle Proteine wurde ein equiner Kollagen-Träger …
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Zein nanocarriers for bioactive ingredients encapsulation and delivery
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-12-01
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Escherichia Coli as a New Platform for the Study of Phosphoinositides
<p>Phosphoinositides are membrane phospholipids involved in a wide variety of processes across the tree of life. In eukaryotic cells they function though their role as integral membrane components, anchors for proteins, membrane identity markers, and signaling molecules. Phosphoinositides are …
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INVESTIGATION OF PLANT DERIVED NANOVESICLES FROM PLANT PRODUCTS AS NEW BIOACTIVE INGREDIENTS FOR FOOD SUPPLEMENTS AND FUNCIONAL FOODS DEVELOPMENT
Plant-derived nanovesicles represent an emerging research area that addresses critical challenges such as the stability, bioavailability, and efficacy of traditionally known plant extracts. This thesis explores plant-derived vesicles obtained from arugula leaves (ALVs) as a novel ingredient for the …
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The measurement and interpretation of actively modulated static ankle impedance using a therap[e]utic robot
In this thesis, I conducted an in-vivo study providing measurements of human static ankle mechanical impedance. Accurate measurements of ankle impedance when muscles were voluntarily activated were obtained using a therapeutic robot, Anklebot, and an electromyographic recording system. Important …
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Assessment of the Measurement Repeatability and Sensitivity of a Noninvasive Blood Perfusion Measuring Probe
… One method that has been developed for measuring blood perfusion is a probe that measures the temperature response of the tissue when a thermal event is applied. From the temperature response, the blood perfusion and contact resistance can be estimated by comparing the experimental response to …
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Design and validation of chronic research tools for an implantable closed-loop neurostimulator
… today provide high frequency Deep Brain Stimulation (DBS) for therapeutic modulation of diseased neural circuits. These devices are approved for the treatment of Parkinson's Disease, Essential Tremor and Dystonia, and are in clinical evaluations for Epilepsy and Depression. Despite the …
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Nanocarriers for nose-to-brain delivery: a novel strategy for the treatment of CNS disorders
… a few hundred. Despite the high prevalence and incidence, central nervous system (CNS) disorders are still incurable. The blood-brain-barrier (BBB) precludes the delivery of drugs to the brain, preventing the therapy of a number of neurological disorders. In the last 20 years, intranasal (IN) …
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Anti-inflammatory and joint-protective effects of blueberries in a monosodium iodoacetate (MIA) induced rat model of osteoarthritis
The purpose of this dissertation project was to investigate the anti-inflammatory and joint-protective effects of blueberries and its polyphenols using an in vitro and in vivo study design. The in vitro design used rabbit synoviocytes stimulated with tumor necrosis factor alpha (TNFα). Rabbit …
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