Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 388 for “"In vivo studies"”.
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In Vitro and In Vivo Studies on Bone Formation
… These two aspects are: 1) mechanisms that are involved in the regulation of peak bone density, and 2) evaluation of the in vivo effects of Insulin-like Growth Factor Binding Protein-5 (IGFBP-5) as a potential means to treat osteoporosis.</p> <p>The first study compared two strains of inbred …
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In vivo studies of repressors of RNA polymerase III transcription
… III (Pol III) is responsible for transcribing a relatively small but vital set of genes, including 5S rRNA and tRNAs. Pol III transcription has been shown to be upregulated in transformed and cancer cells, suggesting an important role in cell growth and proliferation. Its tight regulation …
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In Vivo Studies of the Foreign Body Reaction to Biomedical Polymers
The in vivo foreign body reaction on biomaterials regarding development of foreign body giant cells and formation of fibrous capsules was studied. The first study (chapter II) discusses the development of foreign body reaction with specific lymphocytic immunodeficient mice mainly targeting IL-4 …
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Controlled release polymers : in vivo studies with insulin and other macromolecules
Thesis (Sc. D.)--Massachusetts Institute of Technology, Dept. of Nutrition and Food Science, 1983.
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Rational design, characterization and in vivo studies of antibody mimics against HER2
… 2 (HER2) is a cell surface receptor tyrosine kinase and plays a role in the signal pathways leading to cell proliferation and differentiation. Overexpression of HER2 is found in various cancers including breast, ovarian, gastric, colon, and non-small-cell lung cancers, which makes it an …
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Progesterone Action on Hypothalamic Lhrh Neurons: In Vitro and In Vivo Studies
The present study examined the effect of progesterone (P) on hypothalamic luteinizing hormone-releasing hormone (LHRH) neurons, as estimated by in vitro (superfusion) and in vivo (push-pull perfusion) techniques. The administration of P unequivocally stimulated the release of LHRH from hypothalamic …
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REGENERATIVE MEDICINE STRATEGIES FOR ENDOMETRITIS IN REPRODUCTIVE MARES:IN VITRO AND IN VIVO STUDIES
Endometritis is a fertility-impairing pathology frequent in reproductive mares. Persistent post-breeding induced endometritis (PPBIE) is caused by a uterine inflammatory imbalance, while chronic degenerative endometritis (CDE) involves endometrial fibrotic alterations and has been associated with …
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Photobiomodulation with IR1072nm in the murine CNS: in vitro and in vivo studies
Photobiomodulation refers to low-intensity light therapy (LILT) in the far-red to near-infrared (IR) region of the spectrum (630-1000nm). A peak wavelength, 1072nm (IR1072), in the IR transmission spectrum has been previously shown to have protective effects against UVA toxicity in human …
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Implications of dopamine D3 receptor for glaucoma: in-silico and in-vivo studies
… cause of 12% of visual impairment and 2% of blindness. Glaucoma is characterized by alterations of optic disc and visual field. High intraocular pressure (IOP) is the main risk factor of glaucoma. IOP reduction represents the first step in the management of glaucoma which is eventually followed …
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In vivo studies of suspected mechanisms of DDT-resistance in Blattella germanica (L.)
… and excretion of DDT have been studied in vivo in resistant and susceptible strains of the German cockroach, Blattella germanica (L.). The cockroaches were exposed to various DDT treatments for intervals ranging from 3 to 72 hours. DDT and its metabolites were identified and quantitated …
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In Vivo Studies of Ribosomal RNA Transcriptional Regulation within a Drosophila Stem Cell Lineage
… Upregulated rRNA levels have been observed in many types of cancers. However, the extent to which rRNA transcription is differentially regulated in cells within the same lineage during differentiation in vivo and how changes in rRNA levels affect cell fate determination remains unclear. Here …
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Roles of the P2X7 receptor in C6 astroglioma: in vitro and in vivo studies
The purinergic P2X7 receptor (P2X7R) is an ionotropic adenosine triphosphate(ATP) receptor which is closely linked with pathological conditions in the central nervous system (CNS). Gliomas are the most common primary brain tumors with presently no cures. The roles of the P2X7R in these diseases …
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The synthesis and evaluation of estrogenic probes for in vitro and in vivo studies
… group has for over twenty years had a strong interest in developing molecular probes for steroid hormone receptors, and in particular, the estrogen receptor (ER), in order to further elucidate its structure and function, and to aid in the clinical evaluation and treatment of patients suffering …
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BLUEBERRY POLYPHENOLS AND THEIR EFFECT ON BIOMARKERS OF CARDIOMETABOLIC HEALTH: IN VITRO AND IN VIVO STUDIES
… una buona salute cardiometabolica è una delle principali sfide per la sanità pubblica globale, poiché i disturbi cardiometabolici, incluse le malattie cardiovascolari, il diabete mellito, l'obesità e la sindrome metabolica, rappresentano le principali cause di mortalità e comorbidità a …
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In vitro and in vivo studies on the activating platelet collagen receptor glycoprotein VI in mice
… here focused on the characterization of the murine platelet collagen receptor glycoprotein (GP) VI and was performed to evaluate its potential as an antithrombotic target. The first mAb against (mouse) GPVI, JAQ1, was generated and used to demonstrate that GPVI requires the FcRgamma-chain for …
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Hyaline Cartilage versus Fibrocartilage Formation within Mechanically Loaded Cartilage Constructs: In Vitro and In Vivo Studies
Articular cartilage is a type of hyaline cartilage and it is crucial for joint movements, but aging or injury can cause changes that result in pain and disability. Osteoarthritis (OA) is a major joint disease resulting from advanced cartilage degeneration. Current surgical treatments do not allow …
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In Vivo Studies on the Transcriptional and Posttranslational Regulation of the CCAAT/Enhancer Binding Protein Beta
… gene has CREB responsive elements (CRE) in its promoter, and its transcription is regulated by CREB during adipogenesis. We have generated a mouse line with a deletion of the CRE elements on the C/EBPbeta promoter and stusied the role of these elements in macrophages. We show that the …
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In vitro and in vivo studies on the biotransformation of β-nicotyrine, a minor tobacco alkaloid
β-Nicotyrine is a minor tobacco alkaloid found in both tobacco plants and tobacco smoke. Preliminary studies have shown that β-nicotyrine is pneumotoxic and that the toxicity is mediated via its metabolites formed in reactions catalyzed by cytochrome P-450. The in vitro metabolic fate of …
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