Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 128 for “"In vivo imaging"”.
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Nanoshells in vivo imaging using two-photon excitation microscopy
… development and optical characterization of near infrared (NIR) gold nanoshells for the use as luminescent contrast agents for applications in small animal blood vessel imaging. Two types of gold-silica nanoshells excitable by NIR lasers are investigated: Type 1 nanoshells can be excited with a …
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In vivo imaging and morphogenesis of butterfly scale development
During metamorphosis, the wings of a butterfly sprout hundreds of thousands of scales with intricate micro- and nanostructures that determine the wings' optical appearance, wetting characteristics, thermodynamic properties, and aerodynamic behavior. This strategy—of enabling multifunctionality by …
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Optimization of small molecule chemical tools for in vivo imaging
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-12-04 without embargo terms
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Ultrasound backscatter microscope for In vivo imaging of human fingertip
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1998.
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Engineering genetically-encodable MRI contrast agents for in vivo imaging
Magnetic resonance imaging (MRI) is gaining recognition as a powerful tool in biological research, offering non-invasive access to anatomy and activity at high spatial and temporal resolution. However, the range of biological phenomena accessible to measurement by MRI is limited, due to a current …
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Development and Applications of Laminar Optical Tomography for In Vivo Imaging
Laminar optical tomography (LOT) is an optical imaging technique capable of making depth-resolved measurements of absorption and fluorescence contrast in scattering tissue. LOT was first demonstrated in 2004 by Hillman et al [1]. The technique combines a non-contact laser scanning geometry, similar …
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In Vivo Imaging of Neutrophil Responses to Localized S. aureus Infection
Methicillin-resistant Staphylococcus aureus (MRSA) is a highly virulent, multidrug –resistant pathogen responsible for the majority of soft tissue infections. The role of neutrophils in S. aureus soft tissue infections is currently unclear. The objective of this thesis was to characterize early …
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In vivo imaging of long-term changes in the Drosophila neuromuscular junction
… die Entstehung neuer glutamaterger Synapsen in vivo zu beobachten. In dieser Arbeit wurden Protokolle etabliert, die die Beobachtung einzelner postsynaptischer Rezeptorfelder in einem definierten Zeitintervall erlauben. Hierzu wurden transgene Fliegenstämme etabliert, die es ermöglichten, …
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In vivo imaging of cortical porosity by synchrotron phase contrast micro computed tomography
… changes throughout life. An improved understanding of the spatio-temporal process of remodeling holds great promise for improving our understanding of bone development, maintenance and senescence. The use of micro-computed tomography (µCT) on living animals is relatively new and allows the three …
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Novel in vivo imaging approaches to study embryonic and adult neurogenesis in the mouse
… is the process of generation of neurons during embryonic development and adulthood. The focus of this doctoral work is the study of the cell biological aspects of neurogenesis and the mechanisms regulating the switch of neural stem cells from proliferation to differentiation. During …
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Rare-Earth Nanoparticles for Non-invasive In Vivo Imaging of Immune Cells in Cancer Immunotherapy
Cancer immunotherapy is fast emerging as a promising treatment approach for many cancers. However, outcomes remain highly variable across individuals, as only a minority of patients respond, and addressing this variability is one of the most active areas of immunotherapy research. Studies have …
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Development of fluorescent semi-conductor nanocrystal conjugates for in vitro and in vivo imaging applications
… also known as quantum dots (QDs), are promising imaging probes with characteristic optical properties: tunable bandgap from visible to infrared, narrow and symmetric emission features, broad absorption, high quantum yield (QY), excellent photostability, and a large two-photon absorption cross …
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IN VIVO IMAGING OF STEM CELL MEDIATED TREATMENT IN A MOUSE MODEL OF SPINAL CORD INJURY
Introduction: The use of adult stem cells in cell-mediated therapies is an area of considerable interest within tissue regeneration research. However, important variables such as the distribution of the injected cells, cell survival, target organ localisation cell proliferation and differentiation …
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From in vitro to in vivo imaging: advanced computational methods for multi-scale biomedical image analysis
… è presente nell'allegato / the abstract is in the attachment
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3D dynamic in vivo imaging of joint motion: application to measurement of anterior cruciate ligament function
… than 400,000 anterior cruciate ligament (ACL) injuries occur annually in the United States, 70% of which are non-contact. A severe consequence of ACL injury is the increased risk of early-onset of osteoarthritis (OA). Importantly, the increased risk of OA persists even if the ACL is surgically …
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Advanced in vivo imaging of the interactions between vascular and renal development in the zebrafish pronephric kidney
… and renal dysfunction are often mutually reinforcing conditions, although the factors underlying this relationship are not fully understood. Cardiac remodelling resulting from disease is partly caused by the reactivation of developmental programmes. By unravelling the mechanisms that drive …
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In vitro and in vivo imaging of peptide-encapsulated polymer nanoparticles for cancer biomarker activated drug delivery
… most significant public health problems not just in the United States, but worldwide. While one of the most effective treatment protocols for cancer is chemotherapy, the conventional agents used in chemotherapy affect normal tissue as well as cancerous tissue. This thesis reports the development …
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Synthesis and evaluation of fluorine-18 labeled androgens as in vivo imaging agents for prostatic cancer using PET
In order to develop androgen receptor (AR) based probes for in vivo imaging of prostatic cancer using positron emission tomography (PET), four pairs of 16$\beta$- and 16$\alpha$-fluoro androgens, as well as two 20-fluoro androgens have been synthesized. The fluorination was achieved mainly by …
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Activatable photoacoustic contrast agents for sensing and delivering nitric oxide, and development of small molecule photoacoustic platforms with improved properties for in vivo imaging
Molecular imaging is a rapidly expanding and highly interdisciplinary field which strives to visualize and (ideally) quantify chemical and biological processes in living systems. Fortunately, the accessibility of microscopy instrumentation, the commercial availability of a variety of fluorescent …
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Development of Hif-1Α/Hif-1Β Heterodimerization Inhibitors Using A Novel Bioluminescence Reporter Assay System For In Vitro High Throughput Screening and In Vivo Imaging
… growth often outpaces its vascularization, leading to development of a hypoxic tumor microenvironment. In response, an intracellular hypoxia survival pathway is initiated by heterodimerization of hypoxia-inducible factor (HIF)-1α and HIF-1β, which subsequently upregulates the expression of …
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