Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"In vivo Evaluation"”.
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An in vivo evaluation of aneuploid hematopoietic stem cell fitness
… Studies of yeast, mouse and human cells harboring one extra chromosome have demonstrated that aneuploid cells show a number of common phenotypes in vitro, notably decreased proliferation. However, the precise role of aneuploidy in cancer has yet to be elucidated, in part due to lack of …
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Engineering Musculoskeletal Tissue: In vitro and in vivo evaluation of novel scaffolds and growth factors for bone regeneration
Introduction: The management of bony non-unions and large bone defects due to congenital deformities, trauma, degenerative disease, and oncological resection remains a complex challenge for orthopaedic surgeons. Currently, autologous bone grafting is the ‘gold standard’ treatment for non-unions and …
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Pre-clinical development of cyclodextrin-based nanoparticles for oral delivery of protein/peptide drugs-in vitro and in vivo evaluation
Over the past decades, oral protein delivery has become a major research area for pharmaceutical companies. Ideally, once the protein is orally administered, it should remain stable until it reaches the targeted site of absorption in spite of the myriad of factors that could hinder its stability, …
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A new blood pump and oxygenator system for support of infants with neonatal respiratory distress: preliminary in vitro and in vivo evaluation
A clinical need exists for a blood oxygenator and pumping system for the support of neonates with respiratory deficiencies. Such systems now available for support of adults are not suitable for neonatal patients. In vitro evaluation of a new blood oxygenator and blood pumping system was performed. …
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Anthocyanins and proanthocyanidins from blueberry and blackberry fermented beverages to reduce inflammation and type-2 diabetes: a comprehensive in vitro and in vivo evaluation
… U.S. population and is aggravated by diets low in fruit and vegetable intake leading to postprandial oxidative stress and inflammation. Berries are one of the richest dietary sources of polyphenolic compounds associated with decreased markers of chronic inflammation and decreased risk for type-2 …
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The synthesis and in vivo evaluation of chemically modified siRNAs that contain red-shifted internal azobenzene derivative spacers for selective and tunable photocontrol of activity without UV light
Short interfering RNAs (siRNAs) are biopolymers that are used for post-transcriptional gene regulation and act as endogenous defenses against attack from viruses and dsRNA parasites. The siRNA field is making advances for use as pharmaceuticals and biomolecular research tools for the study of gene …
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Drug delivery of paclitaxel for an intraperitoneal chemotherapy
Peritoneal carcinomatosis (PC) is a frequent phenomenon in the course of gastroinstestinal and ovarian cancer and is responsible for a high mortality. In recent years, hyperthermic intraperitoneal chemotherapy (HIPEC) after cytoreductive surgery has been introduced as an alternative treatment. An …
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PHARMACOKINETICS AND ORAL DELIVERY OF POLYMETHOXYLATED FLAVONES
… are constituents of many herbs and edible plants in nature. Their broad spectrum of pharmacological activities such as anti-inflammatory, anti-cancer, anti-diabetic, anti-bacterial, anti-fungal, blood thinning and neuro-protective effects have been reported extensively. To further evaluate the …
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Studies in Marine Natural Product Synthesis, Isolation and Ecology
Previous studies indicated the marine pyridoacridone alkaloid ascididemin possessed a unique biological profile. Investigation of synthetic routes to ascididemin led to the discovery that ascididemin precursors possessed a wide range of biological activities. One precursor possessed hollow fiber in …
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Development of New Radiolabeling Methods and Insights on Ionizing Radiation Interactions with Nanoparticles
<p>Nanoparticles are often combined with radionuclides for various applications, ranging from waste remediation to imaging and therapy in the medical field. The overarching aim of this body of work is two-fold. The first aim is development of new radiolabeling methods for various nanoparticles that …
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Long silicon microfluidic needles for VTA and in-vivo differential neurochemical measurement
… presents the design, fabrication, and preliminary in vivo evaluation of long silicon microfluidic neural probes intended for high-resolution neurochemical sampling from deep brain nuclei such as the ventral tegmental area in mice. The work first analyzes stress-induced bending in thinfilm …
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Wavelength swept spectrally encoded confocal microscopy for biological and clinical applications
… (SECM) is a technique that facilitates the incorporation of confocal microscopy into small, portable clinical instruments. This would allow in vivo evaluation of cellular and sub-cellular features in a non-destructive, minimally invasive manner. Prior studies have demonstrated the potential …
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Synthesis and SAR study of Meperidine Analogues as Selective Serotonin Reuptake Inhibitors (SSRIs)
Meperidine has been shown to have potent binding affinity for serotonin transporters (SERT) (Ki = 41 nM) and be an inhibitor of serotonin reuptake. Based upon these pharmacological results meperidine has been identified as a lead compound for the development of a novel class of serotonin-selective …
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Synthesis and evaluation of radioactive gold nanoparticles for cancer treatment and imaging
… that may be more appropriate for treating cancer. The first protocol includes using a nontoxic and antitumor phytochemical reductant agent, Mangiferin that can be used to produce radioactive gold nanoparticles to treat and image prostate cancer while the second protocol uses sodium …
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Combinatorial approach to multi-substituted 1,4-Benzodiazepines as novel non-peptide CCK-antagonists
… a library of 168 multisubstituted 1,4-benzodiazepines were prepared by a 5-step solid phase combinatorial approach. Substituents were varied in the 3,5, 7 and 8-position on the benzodiazepine scaffold. The combinatorial library was evaluated in a CCK radiolabelled binding assay and CCKA …
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Die stabiliteit van parasetamol in vaste doseringsvorme
The objectives of this investigation were to: i) develop a stability indicating method for paracetamol tablets; ii) formulate and prepare different paracetamol tablets and to compare the bioavailability and physicopharmaceutical properties of these tablets and presently registered tablets; iii) …
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