Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 57 for “"In vitro testing"”.
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Design of 3D bioengineered cardiac tissue models for advanced in vitro testing
… è presente nell'allegato / the abstract is in the attachment
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Unravelling Spiral Ganglion Neuron Electrophysiology: Heterogeneity, Gene Therapy, and In-Vitro Testing Models
Hearing impairment is a prevalent global health challenge, and cochlear implants (CIs) have emerged as a transformative solution for individuals with severe to profound hearing loss. However, the variability in CI outcomes, especially in complex listening situations, underscores the need for …
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The design, development and in vitro testing of an electric motor driven artificial heart
The blood pumping chambers and drive pump for a totally implantable artificial heart have been developed at the biomedical engineering laboratory. The drive pump is driven by an electric motor and provides alternate pumping of the blood pumping chambers. The blood pumping chambers are diaphragm …
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Study on the performance enhancement of biomedical implants: in vitro test under UV irradiation of titanium anodised in mixed electrolyte
Titanium (Ti) recently has widely been used in the biomedical applications due to its high performance. Therefore, surface modifications of titanium have attracted a lot of interest to provide better osseointegration. Ti was subjected to anodic oxidation process and in vitro testing to assess the …
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Development and Validation of a Novel Diffusion Chamber for In Vitro Permeability Testing of Topically Delivered Spray Formulations
In vitro testing of pharmaceutical formulations is an integral part of development of new drugs and formulations. The use of in vitro tests, which have a better in vitro-in vivo correlation, allows for a more efficient transition from in vitro testing to animal studies. Current testing protocol …
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Development & testing of ultrasound enhanced prodrug microbubble drug delivery system
Microbubble drug delivery systems vary widely in their design and. This work focused on the application of a novel microbubble system with ultrasound-mediated delivery enhancement via consumer equipment. The work involved the creation of a novel microbubble formulation using a prodrug of Bexarotene …
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BIORELEVANT RELEASE TESTING OF LONG-ACTING INJECTABLES INTENDED FOR PARENTERAL ADMINISTRATION
In vitro release testing is pivotal in supporting various stages of pharmaceutical development, from formulation design to routine quality control. Its implementation ensures the consistent quality, performance, and regulatory compliance of medicinal products. For orally administered small-molecule …
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Cholinesterase Inhibitors and Neuropathology of Cerebrovascular Disease and Other Dementias in Patients with Alzheimer’s Disease: A Study of NACC Autopsy and Medical History Data, 2005 – 2017
In vitro testing of cholinesterase inhibitors suggested protective effects against neuronal toxicity from multiple sources. Investigations in primates found ChEI restored cerebral blood flow. Work in animals suggests ChEI may have a neuroprotective effect, though not necessarily impacting …
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The development of a system of 24 hours preservation of the heart for transplantation
This thesis describes a series of investigations into the problems that hamper the progress of myocardial preservation for transplantation in man. Six positive aspects of cardiac preservation have emerged from this study: - (1) A clear fluid hyperosmolar solution was formulated that adequately …
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In-vitro Glioblastoma Treatment Focusing on Convection Enhanced Delivery
Glioblastoma is a deadly brain cancer with discouraging standard of care. New methods like convection enhanced delivery and chimeric antigen receptor T cells (CAR-T) are promising treatments that can be translated to glioblastoma. In this study, CAR-T cell flow through a hydrogel was explored in …
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Entwicklung eines Hepatozytenbioreaktors zur Anwendung in der Toxikologie und Metabolismusforschung
New approaches for in vitro testing of hepato-mediated toxicity are undertaken to offer alternatives to in vivo animal testing. The described bioassay for hepato-mediated toxicity testing is based on a small scale hepatocyte-bioreactor with pig hepatocytes connected to a silicon sensor based …
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Do bacteria implicated in Ventilator-Associated Pneumonia adapt to antibiotic exposure?
… have been key to the treatment of bacterial infections since their introduction, but the increasing levels of antimicrobial resistance is a concern. Patients with serious respiratory conditions, such as those often encountered within critical care units like ventilator-associated pneumonia …
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The synthesis and characterization of water soluble platinum (II) pophyrins and their potential as radiosensitizers
… The lack of oxygen creates regions of hypoxia in the tumor, which are resistant to radiation. The radio resistance of these hypoxic regions arises because dioxygen present in healthy tissues interacts with radiation to create toxic, high-energy radicals which damage important cellular …
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The R563Q mutation of the beta subunit of the epithelial sodium channel : prevalence and effect
… genes that contribute to blood pressure is ongoing. The epithelial sodium channel genes were implicated when the beta subunit (SCNN1B, gene ID 6338) was found to have a mutation that caused Liddle’s syndrome. The R563Q mutation in the beta subunit has been associated with hypertension and …
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Design of a Robotic Equine Forelimb for Testing Load-Bearing Rehabilitative Devices
… horses are animals of flight, bone fractures in the horses' limbs are quite common. When foals fracture a bone in their leg, the healthy leg is often compromised. During convalescence, the animal tends to overstress the healthy leg in an attempt to relieve the stress on the injured leg. This …
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In vitro bioactivities of anodised titanium in mixtrue of B-Glycerophosphate and calcium acetate for biomedical application
… to modify the surface properties of titanium in order to improve the biocompatibility after implantation. In this study, high purity titanium foils were exposed in a mixture of β-glycerophosphate disodium salt pentahydrate (β-GP) and calcium acetate monohydrate (CA). The parameters for anodic …
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Self-Assembling Peptide Nanofibers RADA16 and IEIK13 for Rapid Hemostasis
Blood loss and trauma remain a significant cause of mortality in both the military and for civilians. This mortality can be reduced through the development of hemostatic bandages to reduce bleeding and prolong life in the prehospital setting. Many successful hemostat materials exist but there is …
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Passive Stiffness Characteristics of the Scoliotic Lumbar Torso in Trunk Flexion, Extension, Lateral bending, and Axial Rotation
As the average American age increases, there is a need to study the spine biomechanics of adults with scoliosis. Most studies examining the mechanics of scoliosis have focused on in vitro testing or computer simulations, but in vivo testing of the mechanical response of a scoliotic spine has not …
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In vitro methods to predict aerosol drug deposition in normal adults
… aimed at the development and validation of new in vitro methods capable of predicting in vivo drug deposition from dry powder inhalers, DPIs, in lung-normal human adults. Three physical models of the mouth, throat and upper airways, MT-TB, were designed and validated using the anatomical …
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