Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"In vitro permeation"”.
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Mechanistic study of nanoemulsion absorption and its application for permeation enhancement
<p>Oil in water (o/w) nanoemulsion is a two-phase dispersed system in which the oil can incorporate poorly water soluble drugs to form a liquid dosage form. The enhancement of bioavailability with a use of nanoemulsion has often been reported empirically and speculated to be a result of the …
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Preparation and Characterization of Lyophilized Cyclodextrin Complexes of a Hemisuccinate Ester of Delta-9-Tetrahydrocannabinol for Transmucosal Delivery
Delta-9- Tetrahydrocannabinol (THC) is the primary active ingredient of the plant Cannabis sativa (marijuana), responsible for the majority of the pharmacological effects. The most promising clinical applications of THC approved by the Food and Drug Administration (FDA) are for the control of …
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The use of ion pairs to increase the percutaneous delivery of diclofenac
… challenges due to the highly effective skin barrier. This research explored a novel amino acid-based ion pairing strategy to enhance percutaneous DF delivery through rational counterion selection and solvent optimisation. The investigation progressed through three phases. First, potential …
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Conformable Ultrasound Face Patch for Cavitation-enhanced Transdermal Cosmeceutical Delivery
Increased consumer interest in healthy-looking skin demands a safe and effective method to increase transdermal absorption of innovative therapeutic cosmeceuticals. However, permeation of small-molecule drugs is limited by the innate barrier function of the stratum corneum. In this thesis, we …
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Development and formulation of wax-based transdermal drug delivery systems
Topical and transdermal formulations are promising platforms for the delivery of drugs. A unit dose topical or transdermal drug delivery system that optimises the solubility of drugs within the vehicle provides a novel dosage form for efficacious delivery that also offers a simple manufacture …
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Advanced Electrohydrodynamic Atomisation Engineered Microneedle Coatings
Transdermal drug delivery (TDD) is an emerging field in the pharmaceutical remit compared to conventional methods (oral and parenteral). Microneedle (MN) based devices have gained significant interest as a strategy to overcome the skins formidable barrier; the stratum corneum and enhance drug …
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Optimization of porcine buccal mucosa for in vitro evaluation
<p>Porcine buccal mucosa has been extensively used as in vitro model to study the permeability of drugs and assess their potential to deliver through buccal route. Porcine buccal mucosa is found to be very similar to human oral mucosa in structure and function. However, the in vitro permeation …
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Development of antibiotic microneedle delivery systems for tuberculosis treatment
… has several limitations, such as risk of liver injury and intestinal dysbiosis due to frequent oral administration of antibiotics. Transdermal administration could be used to improve antibiotic delivery for treatment of Mycobacterium tuberculosis infection. Therefore, this thesis described a …
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Development of dissolving and hydrogel-forming microneedles for delivery of vancomycin hydrochloride
Methicillin-resistant Staphylococcus aureus (MRSA) can cause harmful and potentially deadly infections, including neonatal sepsis. Vancomycin, a glycopeptide antibiotic, remains the most effective antibiotic to treat this condition. In the case of systemic diseases, vancomycin must be administered …
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Preparation And Characterization Of Acitretin-Loaded Niosomes For Psoriasis Treatment
Psoriasis is a chronic skin disease that manifests as impaired epidermal differentiation. The disease is typically treated with acitretin, an effective oral cytotoxic agent. However, due to its side effects, its use is highly limited. Topical delivery of acitretin may decrease the systemic toxicity …
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Analytical Studies Concerning the Stability of Betamethasone Valerate and Fusidic acid Hemihydrate in Topical Pharmaceutical Preparations
The research work presented in this thesis describes studies concerning the stability of the drug substances betamethasone 17-valerate and fusidic acid hemihydrate in topical pharmaceutical formulations. In particular, the work concentrates on formulation factors affecting the intra-molecular …
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Functionality And Role Of Different Fatty Alcohols In Topical O/W Cream Formulation
… alcohols are excipients that are abundantly used in various pharmaceutical formulations. The objective of the present study was to evaluate the impact of incorporating different fatty alcohols on microstructural and formulation characteristics of topical o/w clotrimazole cream formulation. The …
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Nose to Brain Delivery of Therapeutic Agents
… associated with central nervous system are invasive and do not allow frequent administration. Brain targeting of drugs by intranasal route is a safe and noninvasive method of drug delivery which allows frequent administration and is certainly more patient compliant than the currently …
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Chemical and physical methods of enhancing the percutaneous absorption of antimicrobial agents
… bacteria exist not only on the surface of the skin but they are also distributed at varying depths beneath the skin surface. Hence, in order to sterilise the skin, antimicrobial agents are required to penetrate across the skin and eliminate the bacteria residing at all depths. Chlorhexidine is an …
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In vitro evaluation of the enzyme inhibition and membrane permeation properties of benzophenones extracted from honeybush
… beverage and has been shown to possess medicinal properties. Honeybush plants contain phytochemicals that can contribute to the prevention of certain diseases. One mechanism through which glucose and fat uptake can be controlled by honeybush tea is enzyme inhibition in the gastrointestinal …
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IN VITRO IN VIVO METHODS AND PHARMACOKINETIC MODELS FOR SUBCUTANEOUSLY ADMINISTERED PEPTIDE DRUG PRODUCTS
Over the last several years, injectable drugs have been a growing area for the treatment of various therapeutic conditions and they are projected to comprise an even larger proportion among the drugs that will be available in the years to come. The injectable drugs are administered by various …
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The use of nanotechnology in enhancing the efficacy of cosmetic actives of natural origin
… natural cosmetics has had a strong and lasting impact on the cosmetics development. However, producing efficient and acceptable natural products presents a major technical challenge. The aim of this study was to investigate how adaptation of a new technology (nanotechnology) could influence …
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EVALUATION OF PHARMACEUTICAL AND COSMETIC USE OF EXCIPIENTS OBTAINED FROM CITRUS PROCESSING WASTE PRODUCTS
… of natural resources and pollution are pushing society towards the development of models based on sustainability and recycling. In recent years, the use of food industry waste as new materials in pharmaceuticals and cosmetics has attracted increasing interest. In this circular economy …
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Sublingual drug delivery: In vitro-in vivo correlation
<p>Administration of drugs sublingually allows direct absorption into the systemic circulation which results in quick onset of action and a higher bioavailability as a consequence of by-passing first pass metabolism. Absorption of drugs across sublingual mucosa is typically determined by means of …
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Critical Quality Attributes of Topical Semi-solid Dosage Forms: Solvent Activity
Critical quality attribute has been defined as “a physical, chemical, biological or microbiological property or characteristic that should be within an appropriate limit, range, or distribution to ensure the desired product quality”. Deviations from preset quality metrics may potentially result in …
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