Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"In vitro effect"”.
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IN VITRO EFFECT OF STATINS ON STREPTOCOCCUS MUTANS, STREPTOCOCCUS SANGUIS, AND STREPTOCOCCUS SALVARIUS
Objectives: Cardiovascular disease (CVD), including heart attack, angina, and stroke, is ranked as the number one cause of mortality world wide. High blood cholesterol is linked to CVD and is an important risk factor. Statins – cholesterol lowering drugs- are first choice drugs for reducing the …
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The in vitro effect of a tooth bleaching agent on coffee and wine stained teeth
… study is to assess the efficacy of a tooth bleaching agent by evaluating the degree of color change with the use of a spectrophotometer and not by the usual subjective, visual methods. Methodology: Twenty specimens of human teeth will be collected, polished and divided into two groups. A baseline …
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The in vitro effects of heavy metals and nanoparticles on the immune system
Heavy metals and nanoparticles may be released into the environment due to their use and applications. Sources of high, toxic metal concentrations may result from leachates from hazardous waste sites, discharge from industrial plants, and effluents from wastewater treatment plants being released …
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ΔΙΑΤΑΡΑΧΕΣ ΤΩΝ Τ-ΛΕΜΦΟΚΥΤΤΑΡΙΚΩΝ ΥΠΟΠΛΗΘΥΣΜΩΝ ΣΕ ΑΣΘΕΝΕΙΣ ΜΕ ΜΕΓΑΛΟΒΛΑΣΤΙΚΗ ΑΝΑΙΜΙΑ
… CHARACTERISED BY MANY AUTOIMMUNE FEATURES. IN THIS STUDY I INVESTIGATED THE LYMPHOCYTE SUBPOPULATIONS IN THE BLOOD OF PATIENTS WITH MEGALOBLASTIC ANEMIA AND THE IN VITRO EFFECT OF STEROIDS ON T-LYMPHOCYTES OF THESE PATIENTS. THE RATIO OF HELPER TO SUPPRESSOR T-CELLS IN PATIENTS WITH …
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Design and development of a bioreactor for ligament tissue engineering
Mechanical signals applied in-vitro to cell-scaffold construct may induce the formation of ligament-like structure having in-vivo functional properties. To explore this hypothesis, a novel bioreactor was designed to study the in vitro effect of biaxial cyclic mechanical stimulation on the adhesion, …
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Rat liver nuclear envelope insulin binding and its effects on endogenous protein kinases
The postulated model for the insulin - stimulated induction of mRNA efflux (Purrello et al., 1983) is based on the demonstrated binding of insulin to intracellular membrane structures (see chapter 2, section 2.2.1), and the in vitro effect of insulin on nuclear envelope phosphorylation, NTPase …
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Malignant Glioma: Chemosensitivity testing and Biomarkers
Chemosensitivity testing and molecular biomarkers are commonly used methods during the management of several types of malignant tumours in routine clinical practice. The present work attempts to transfer the use of these two concepts to the management of malignant gliomas. Chemosensitivity testing …
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Phenotype and function of B cells in children infected with human immunodeficiency vius
HIV infection has been shown to affect all lymphocyte populations, including the B-cell compartment. Defects in phenotype and function of B cells have been well characterized in HIV -infected adults. However, only a few studies have investigated the effect of HIV on the B-cell compartment in …
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Differenziamento macrofagico: gli effetti dei polimeri sintetici
… and easily implantable materials continuously proposes new molecules and new substances with biological, chemical and physical characteristics, that are more and more adapted to aesthetic and reconstructive surgery and to the development of biomedical devices such as cardiovascular …
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Systemic inflammatory regulation of blood-brain barrier inflammation
The endothelial cells of the blood-brain barrier are essential for the maintenance of homeostasis in the central nervous system. These cells act as a physical and transport barrier, restricting the movement of systemic immune cells and blood components into the brain. The physical barrier is …
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Exploring Anti-FVIII Antibodies in Haemophilia A - Role in In Vitro Haemostasis and Clinical Disease
… factor VIII(FVIII), which has serious effects on haemostasis; joints being the most common site of bleeding. The development of FVIII replacements has improved the situation for patients with haemophilia such that chronic arthropathy can be prevented, and life expectancy and the quality …
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Anti-platelet aggregation activity of melaleuca bracteata var.revolution gold derived betulinic acid and its derivatives
Abnormal Platelet aggregations are implicated in the onset of cardiovascular diseases which are the leading cause of death and disability globally. Management of pathological platelet aggregation with medicinal plants is a promising approach in treatment of cardiovascular diseases. In this study, …
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The identification, purification and characterization of the fetal rat liver glutathione S-transferase isoenzyme YcYfetus
This study has examined the expression of the glutathione S-transferases (GSH S-T) in fetal rat livers in order to provide more information about the role played by this important group of enzymes in the fetus. The study commenced with an examination of the subunit composition of adult and fetal …
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Targeting LGALS3 to treat steatotic liver disease and hepatocarcinogenesis
… steatotic liver disease (MASLD), is the leading cause of chronic liver disease (CLD) and liver-related morbidity and mortality worldwide. NAFLD, characterized by hepatic fat accumulation and coexisting cardiometabolic risk factors, is often clinically associated with liver fibrosis, with a …
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Functionality of Azadirachta indica A. Juss (neem) in beverages
A significant increase in the health consciousness of people all around the world has rekindled interest in age old medicinal systems such as Ayurveda and Unani. The various trees, herbs and shrubs used in these ancient practices are being incorporated today into foods and beverages to meet the …
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Investigation of the effect of disulfiram on the chemoresistance and invasiveness in pancreatic cancer cells
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers worldwide with a mortality to incidence ratio of 94%. It is the 10th most common cancer in the UK with a 5-year survival less than 7%. In contrast to the improved therapeutic outcomes in many other cancers, the prognosis of …
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Studies on transient receptor potential vanilloid subtype 1 (TRPV1)-mediated degeneration of mesencephalic cellsin vivo and in vitro
… an oligomeric structure formed by subunits having six transmembrane segments with a pore domain formed by the fifth and sixth transmembrane regions. This receptor is a nonselective cation channel activated by the vanilloids or products of lipoxygenases, and protein kinase C and phospholipase C …
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Studies on the Mechanism of Polyamine-and Prothrombin kringle-2-induced Degeneration of Neuron and Microglia
Neural cell death is the defining feature of all neurodegenerative diseases and is the underlying cause of many functional deficits. Clarifying the mechanism of cell death in the nervous system is essential to understand disease pathology and to devise effective treatment strategies. Increasing …
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Voltage Effects on Cells Cultured On Metallic Biomedical Implants
<p>Electrochemical voltage shifts in metallic biomedical implants occur in-vivo due to a number of processes including mechanically assisted corrosion. Surface potential of biomedical implants and excursions from resting open circuit potential (OCP), which is the voltage they attain while in …
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An in vitro study of the effects of free fatty acids on insulin mediated glucose uptake and metabolism by myocytes and fibroblast derived adipocytes
The incidence of type 2 diabetes (T2D) is increasing at an alarming rate, especially in developing countries, including South Africa. In developing countries, changes in lifestyle, especially the increase in the consumption of a westernized diet, rich in fats and sugar, is associated with …