Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"In situ gel"”.
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A Novel IN SITU Gel for Sustained Drug Delivery and Targeting
The deacetylated form of chitin known as chitosan is currency been investigated due to its biodegradability, biocompatibility, non-toxic nature and its ability to form in situ gel with pH changes. Chitosan has also been shown to be mucoadhesive due to its polycationic nature. Hydrophobic lipids, …
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Development of Topical Ophthalmic In Situ Gel-Forming Estradiol Delivery System Intended for the Prevention of Age-Related Cataracts
The increased risk of cataracts in aging women versus men, the reduced risk in women on hormone replacement therapy, and studies in animal models suggest that estrogen may protect lens transparency. To use estrogen for cataract prevention, we hypothesized that an ophthalmic estradiol in situ …
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Development and Characterization of Fluocinolone Acetonide Loaded Nanosized Lipid Carriers for Ocular Delivery via Subconjunctival Route: Synergistic Effect of Vitamin a Palmitate
… therapeutic application have embarked as an emerging tool for drug delivery applications, the delivery of therapeutic molecules into deep ocular compartments has always been a challenging task. In this regard, the main objective of our current investigation was to develop and evaluate the …
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Injectable in situ Gelling Metronidazole System for Treating Jawbone Infections
… dental cavity or an accumulation of bacteria in the side of the teeth or around an implant can cause jawbone infection. This is treated by incision and drainage, root canal treatment or extraction in combination with a prolonged course of antibiotic therapy. Metronidazole is effective against …
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Intranasal delivery of therapeutics targeted to CSF and Brain
Blood-brain barrier and blood-cerebrospinal fluid barrier limit the systemic delivery of therapeutics to the brain and cerebrospinal fluid (CSF) respectively. Therapeutic agents targeting CNS are currently being administered by invasive routes which are not patient compliant and do not allow …
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Preparation, Characterization and Toxicity Evaluation of a Novel Sustained Release Delivery System for a Hydrogen Sulfide Donor - GYY 4137
… disease that is characterized by elevated intraocular pressure (IOP) and neurodegeneration of retina ganglion cell (RGC) and optic nerve head (ONH), leading to blindness. Although the current therapies are aimed at decreasing IOP, a small proportion of open angle glaucoma patients exhibit …
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In vitro Sustained Release Delivery System for Hydrogen Sulfide Analogs
A large population is suffering from ocular diseases within US and worldwide. Glaucoma is the most common age-related optic nerve disease and the most common neuropathy. The current treatment regimen for management of glaucoma is targeted towards lowering IOP alone with little or no concern towards …