Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"In situ click"”.
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Development of biotin protein ligase inhibitors from Staphylococcus aureus as new antibiotics
Biotin protein ligase (BPL) catalyses the ordered reaction of biotin and ATP to give biotinyl-5’-AMP 1.03, which then activates a number of biotin dependent enzymes that are critical to cell survival. Research undertaken in this thesis highlights strategies to selectively inhibit Staphylococcus …
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Mechanistic insights into the cancer cell cytotoxicity and blood stability of the garlic compound ajoene
… designed to probe structure-activity relations into cancer cell cytotoxicity and blood stability. Structural variations included introduction of different solubility enhancing terminal groups (amide and phenol) as well as variations in the sulfoxide / vinyl-disulfide core. The phenol ajoene …
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Relating structure and function: Discovery of novel inhibitors of myotonic dystrophy
The projects described herein seek to understand the relationship between the function of the drug and the structure of its target, with the aim of discovering novel therapeutics that target nucleic acid secondary structures, selectively. The structure of the expanded DNA and RNA repeats that cause …
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Mechanochemical activation at solid interfaces
Surfaces functionalization provides an enabling platform for molecular tailoring of the chemical and physical properties of a surface in an on-demand fashion. Prior research has established that self-assembled mononolayer (SAM) functionalization can lead to dramatic changes in surface properties, …
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DISCOVERY OF NOVEL MACROLIDE ANTIBIOTICS AND METHODOLOGY DEVELOPMENT OF N-SULFINYL METALLODIENAMINES
… antibiotics and methodology development of N-sulfinyl metallodienamines. To tackle bacterial resistance, new antibiotics are desperately needed. My research objective is to address this need by designing, synthesizing, and evaluating novel macrolide antibiotics based on the best-in-class drug …